A5063905658- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Cancer therapeutics and mechanisms
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Metastasis and carcinoma case studies
- Lung Cancer Research Studies
- Renal and related cancers
- Nanoparticle-Based Drug Delivery
- Curcumin's Biomedical Applications
- Drug Transport and Resistance Mechanisms
- Polyamine Metabolism and Applications
- Cancer, Lipids, and Metabolism
- Urban and Freight Transport Logistics
- Glycosylation and Glycoproteins Research
- Phagocytosis and Immune Regulation
- Synthesis and biological activity
- Circular RNAs in diseases
- Graphene research and applications
University of the Witwatersrand
2019-2024
Gujarat University
2015-2024
Gujarat Cancer & Research Institute
2015-2024
Ahmedabad University
2017
Aga Khan University
2010
In the intricate field of cancer biology, researchers are increasingly intrigued by emerging role exosomal long non-coding RNAs (lncRNAs) due to their multifaceted interactions, complex modulation mechanisms, and potential therapeutic applications. These lncRNAs, carried within extracellular vesicles, play a vital partin tumorigenesis disease progression facilitating communication networks between tumor cells local microenvironment, making them an ideal candidates for use in liquid biopsy...
Colon cancer stem cells have been attributed to poor prognosis, therapeutic resistance and aggressive nature of the malignancy. Recent reports associated CD44v6 expression with relapse, metastasis reduced 5-year survival colon patients, thereby making it a potential target. Thus, in this study, comprehensive prediction screening against 1674 lead compounds was conducted. Silibinin identified as compound targeting CD44v6. Inorder substantiate these findings, cytotoxic effect 5FU, 5FU+...
Objectives: Acute Myeloid Leukemia (AML) therapy continues to be a daunting challenge. Cytosine Arabinoside (Ara-C) is widely used treat hematological malignancy in humans, but often becomes ineffective because of increased resistance the drug which may lead worse prognosis. Therefore new strategies are needed understand mechanism responsible for and develop therapies overcome it. Research evidence based on natural compounds alone or combination with current chemotherapeutic agents proved...
Background: The aim of the study was to find a role Curcumin from natural source overcome drug resistance as well reduce cytotoxicity profile in Acute Myeloid Leukemia patients. Material and Methods: Primary leukemic cells were obtained AML patient's bone marrow. These then exposed different concentration cytarabine curcumin out IC50 values also its effect on MDR genes like MDR1, BCRP, LRP FLT3 by RT-PCR method. Result & Conclusion: Our results suggested that down regulates genes. Gene...
A library of 1,4-dihydropyridine-based 1,2,3-triazol derivatives has been designed, synthesized, and evaluated their cytotoxic potential on colorectal adenocarcinoma (Caco-2) cell lines. All compounds were characterized identified based
The ultimate goal of the study was to find a role curcumin in targeting lung cancer stem cells by reducing their self-renewal efficiency causing DNA damage.Circulating were isolated sphere formation assay and further analysed flow-cytometry qRT-PCR for presence cell transcription markers. IC50 values gemcitabine MTT assay, while induced damage scrutinized single gel electrophoresis assay.Our results demonstrated that significantly affect ability circulating cells. no. spheres formed shown be...
A series of 1,4-dihydropyridine based compounds bearing benzylpyridinium moiety have been designed and evaluated for in vitro anticancer activity against glioblastoma U87MG, lung cancer A549 colorectal adenocarcinoma Caco-2 cell lines using the MTT assay.Among these compounds, 7b, 7d, 7e, 7f exhibited potent tested. The cytotoxicity synthesized derivatives was compared to standard drugs (carboplatin, gemcitabine, daunorubicin).Thus, 1,4-dihydropyridines can be considered as encouraging...
Lung cancer stem cells are supposed to be the main drivers of tumor initiation, maintenance, drug resistance, and relapse disease. Hence, identification cellular molecular aspects these is a prerequisite for targeted therapy lung cancer. Currently, analysis circulating has potential become diagnostic technique monitor disease progression or therapeutic response as it non-invasive. However, accurate detection remained challenge, epithelial cell markers used so far not always trustworthy...
Abstract Microsatellite Instability (MSI) is a hallmark of colorectal cancer (CRC) and occurs in 15–16% CRC. Molecular biological information CRC South Africa (SA) largely unrecorded. This study was undertaken to determine the frequency MSI, with particular reference Lynch syndrome (LS) view improve surveillance prevention strategies. retrospective on samples diagnosed between 2011–2015 at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH). Samples 2011–2012 were screened for MSI by PCR...
Background and Aim Epidemiological studies of colorectal cancer (CRC) in South Africa (SA) have been poorly characterized. Black white SA population groups demonstrated distinct CRC clinical presentations, suggesting that black patients follow a different carcinogenic pathway than their counterparts. Thus, the aim this study was to identify unique demographic histopathological features associated with facilitate earlier diagnosis improve disease management. Methods This preliminary...
P-glycoprotein (Pgp), an ATP binding cassette (ABC) transporter, is ATP-dependent efflux pump responsible for cancer multidrug resistance. As part of efforts to identify human Pgp (hPgp) inhibitors, we prepared a series novel triazole-conjugated dihydropyrimidinones using synthetic approach that well suited obtaining compound libraries. Several these dihydropyrimidinone derivatives modulate activity with low micromolar EC50 values. Molecular docking studies suggest compounds bind the M-site...
Though cancer associated fibroblasts (CAFs), being a main component of tumor microenvironment (TME), are known to modulate immune response through secretion various growth hormones, exosomes carrying miRNAs and cytokines; their effect on dendritic cells (DCs) yet be elucidated. Thus, aim this study was assess the cytokines released by lung-CAFs evaluate immunomodulatory potential curcumin DC maturation modulating TME.
Background & aim Liver metastasis has been found to affect outcome in prostate, pancreatic and colorectal cancers, but its role lung cancer is unclear. The 5 year survival rate remains extensively low owing intrinsic resistance conventional therapy which can be attributed the genetic modulators involved pathogenesis of disease. Thus, this study aims generate a model for early diagnosis timely treatment liver patients. Methods mRNA expression 15 genes was quantified by real time PCR on...
OBJECTIVE: To identify health problems of wood workers and suggest recommendations for its prevention. METHODS: Extensive online search was made medical literature on it published in English from 1960’s to date.151 articles were retrieved which tailored 124 including books, reviews epidemiological studies.53 them relevant are included this review. RESULTS: Wood exposed dust, fungi, bacteria, endotoxins, formaldehyde, phenol various injuries their working environment. This leads impaired...
Abstract INTRODUCTION: Drug resistance of leukemic stem cells is a surmountable obstacle to effective chemotherapy in acute myeloid leukemia (AML). P-glycoprotein (Pgp) and FLT3 undoubtedly contribute worse prognosis mechanisms these proteins lead shorter survival resistance. Due heterogeneity AML, outcome patients with normal karyotype highly challenging changes drug genes likely be identified which will better understanding the disease biology, eventually leading development alternative...