A5015389141- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Nail Diseases and Treatments
- Plant Pathogens and Fungal Diseases
- Antibiotic Use and Resistance
- Cystic Fibrosis Research Advances
- Enterobacteriaceae and Cronobacter Research
National Health Laboratory Service
2018-2023
University of the Witwatersrand
2018-2021
National Institute for Communicable Diseases
2018-2020
University of California, Irvine
2018
Lancet Laboratories
2018
University of Pretoria
2018
Latino Community Services
2018
Sefako Makgatho Health Sciences University
2018
Office of Diversity and Inclusion
2018
University of Cape Town
2018
To determine the epidemiology of Candida auris in South Africa, we reviewed data from public- and private-sector diagnostic laboratories that reported confirmed probable cases invasive disease colonization for October 2012-November 2016. We defined a case as first isolation C. any specimen person age admitted to healthcare facility Africa. where laboratory had used nonconfirmatory biochemical identification method haemulonii was cultured. analyzed 1,692 cases; 93% were facilities, 92% known...
We aimed to describe the epidemiology of candidemia among children in South Africa.We conducted laboratory-based surveillance neonates (≤28 days), infants (29 days <1 year), (1-11 years) and adolescents (12-17 with Candida species cultured from blood during 2012-2017. Identification antifungal susceptibility viable isolates were performed at a reference laboratory. used multivariable logistic regression determine association between parapsilosis 30-day mortality neonates.Of 2996 cases,...
Candidemia is a major cause of healthcare-associated infections. We describe large outbreak Candida krusei bloodstream infections among infants in Gauteng Province, South Africa, during 4-month period; series candidemia and bacteremia outbreaks the neonatal unit followed. detected cases by using enhanced laboratory surveillance audited hospital wards environmental sampling epidemiologic studies. During July-October 2014, 589 patients, 48 unique C. occurred (8.2% incidence). Risk factors for...
Histoplasma antigen detection in urine is a rapid diagnostic method for disseminated histoplasmosis, although cross-reactivity has been reported specimens from patients with other thermally dimorphic fungal infections. We tested specimens, persons suspected invasive infections, using commercial monoclonal antibody enzyme immunoassay (EIA) at South African national mycology reference laboratory August 2014 through December 2018. Corresponding culture and histopathology results were obtained...
Abstract During 2016–2017, Nakaseomyces glabrata (formerly Candida glabrata) caused 14% of cases candidaemia in South Africa. We aimed to describe the clinical characteristics adults with N. at 20 sentinel hospitals (accounting for 20% (172/917) cases) and antifungal susceptibility corresponding isolates. A higher proportion patients were older (median age: 55 years [interquartile range (IQR): 41–65 years] vs. 49 [IQR: 35-63 years]; p = 0.04), female (87/164, 53% 283/671, 42%; 0.01),...
Candida auris is an emerging multidrug-resistant fungal pathogen associated with high mortality.We investigated the genetic relatedness of clinical C. isolates from patients admitted to either public- or private-sector hospitals, which were submitted a reference laboratory 2012 2015. Patient demographics and details recorded. We performed antifungal susceptibility testing, sequencing hotspot 1 2 regions FKS1 FKS2 genes for all echinocandin minimum inhibitory concentration (MIC) ≥1 µg/mL...
Introduction Cryptococcal meningitis (CM) is an opportunistic fungal disease with a high mortality among HIV-positive patients severe immunosuppression (CD4 count <100 cells/μl). Reflexed screening for cryptococcal antigen (CrAg) in remnant blood samples was initially piloted at selected CD4 testing laboratories of the National Health Laboratory Service (NHLS) prior to implementation national programme using lateral flow assay (LFA) (IMMY, Norman, OK, USA). The aim this study assess CrAg...
Despite widespread access to antiretroviral therapy (ART), the burden of advanced HIV disease in South Africa is high. This translates into an increased risk AIDS-related opportunistic infections, including invasive mycoses.Using a limited number non-culture-based diagnostic assays, we aimed determine prevalence mycoses and tuberculosis among hospitalised adults with very (CD4 counts < 100 cells/µL) at large academic hospital. We conducted interviews prospective medical chart reviews....
Abstract To determine the epidemiology of Candida auris in South Africa, we reviewed data from public- and private-sector diagnostic laboratories that reported confirmed probable cases invasive disease colonization for October 2012–November 2016. We defined a case as first isolation C. any specimen person age admitted to healthcare facility Africa. where laboratory had used nonconfirmatory biochemical identification method haemulonii was cultured. analyzed 1,692 cases; 93% were facilities,...