A5075376412- Antibiotic Use and Resistance
- Patient Satisfaction in Healthcare
- Pneumonia and Respiratory Infections
- Pharmaceutical Practices and Patient Outcomes
- Global Maternal and Child Health
- Patient Safety and Medication Errors
- Problem and Project Based Learning
- Healthcare cost, quality, practices
- Neonatal and Maternal Infections
- Vaccine Coverage and Hesitancy
- Healthcare Systems and Technology
- Bacterial Infections and Vaccines
- Primary Care and Health Outcomes
- Healthcare Operations and Scheduling Optimization
- Family and Patient Care in Intensive Care Units
- Health Policy Implementation Science
- Surgical site infection prevention
- Innovative Teaching Methods
- Electronic Health Records Systems
- Medical Research and Practices
- Infant Development and Preterm Care
- Quality and Safety in Healthcare
- Antibiotics Pharmacokinetics and Efficacy
- Central Venous Catheters and Hemodialysis
- Infection Control in Healthcare
Groote Schuur Hospital
2019-2025
University of Cape Town
2018-2025
Netcare Unitas Hospital
2015-2016
Right to Care
2015
Regions Hospital
1992
Few data exist on the implementation of process measures to facilitate adherence peri-operative antibiotic prophylaxis (PAP) guidelines in Africa.To implement an improvement model for PAP utilizing existing resources, order achieve a reduction surgical site infections (SSIs) across heterogeneous group 34 urban and rural South African hospitals.A pharmacist-driven, prospective audit feedback strategy involving change management principles was utilized. This 2.5 year intervention involved...
Pharmacists in low-middle-income countries (LMIC) are few and lack antibiotic stewardship (AS) training. The ability was assessed of non-specialised pharmacists to implement interventions improve adherence the South African community-acquired pneumonia (CAP) guideline public private hospitals.This a multicentre, prospective cohort study adult CAP patients hospitalised between July 2017 2018. A bundle developed seven process measures (diagnostic AS) that used audit compliance provide...
Ensuring timely administration of antimicrobials is critical in the management patients with infections. Mortality increases by 7.6% for every hour delay antimicrobial therapy sepsis. The time elapsed from written antibiotic order to actual intravenous or 'hang-time' can often be several hours due logistics within hospital. Our purpose evaluate change compliance administering an prescription after implementation a national stewardship pharmacist-driven hang-time process improvement...
Background. Antibiotic resistance (ABR) is a major threat to global health, driven in part by inappropriate prescription of antibiotics primary care. Objectives. To describe South African (SA) prescribers' knowledge of, attitudes and perceptions ABR. Methods. We conducted cross-sectional survey ABR among convenience sample healthcare providers SA, the majority from private sector. used logistic regression examine associations between prescribing behaviours. Results. Of 264 prescriber...
Antibiotic resistance (ABR) is a global health crisis. We conducted cross-sectional survey to describe South African patients' (n = 782) ABR knowledge, attitudes and perceptions (KAP), differences in KAP between public 379, 48%) private 403, 52%) practice respondents associations attitudes, knowledge scores.Knowledge scores (15 questions) were placed into low (0% - 53%) high (> 54%) categories (below above overall mean). Comparisons using chi-squared t-tests.Of all respondents, 72% believed...
Abstract During 2016–2017, Nakaseomyces glabrata (formerly Candida glabrata) caused 14% of cases candidaemia in South Africa. We aimed to describe the clinical characteristics adults with N. at 20 sentinel hospitals (accounting for 20% (172/917) cases) and antifungal susceptibility corresponding isolates. A higher proportion patients were older (median age: 55 years [interquartile range (IQR): 41–65 years] vs. 49 [IQR: 35-63 years]; p = 0.04), female (87/164, 53% 283/671, 42%; 0.01),...
Abstract Introduction The high burden of infectious diseases in South Africa and the misuse overuse antibiotics are driving antibiotic resistance to extent that bacterial infections commonly difficult treat, some cases, untreatable. Implementing stewardship (AS) is challenging due a lack physicians pharmacists trained for treating diseases. Objectives To describe implementation, outcomes, sustainability collaborative Train Trainer (TTT) AS pharmacist mentoring program between US hospital...
Abstract Background Invasive meningococcal disease (IMD) is endemic to South Africa, where vaccine use negligible. We describe the epidemiology of IMD in Africa. Methods cases were identified through a national, laboratory-based surveillance program, GERMS-SA, from 2003–2016. Clinical data on outcomes and human immunodeficiency virus (HIV) statuses available 26 sentinel hospital sites. conducted space-time analyses detect clusters serogroup-specific cases. Results Over 14 years, 5249...
Resilience is having the ability to respond adversity proactively and resourcefully. The coronavirus disease 2019 (COVID-19) pandemic's profound impact on antimicrobial stewardship programs (ASP) requires clinicians call their own resilience manage demands of pandemic disruption ASP activities. This article provides examples from pharmacists physicians seven countries with different resources approaches ASP-The United States, Kingdom, Canada, Nigeria, Lebanon, South Africa, Colombia. lessons...
The World Health Organization urges international collaboration for the containment of antimicrobial resistance (AMR) or ‘superbugs’. If left unchecked, AMR could result in 4.1 million deaths Africa by 2050. Furthermore, without effective antibiotics, surgical procedures would become much riskier and many cases impossible. Antimicrobial stewardship requires a multidisciplinary approach; however, programmes still struggle to achieve ‘reach’ required educate engage all healthcare providers...
Health care-associated infections (HAIs) are among the most common and serious adverse events in hospitals globally, occurring about one 10 admissions overall. A recent meta-analysis shows that HAIs a much bigger problem of developing countries, than those industrialised world. 1 HAI prevalence is 15.5 per 100 patients, at least double overall rate Europe, while incidence acquired intensive care units (ICUs) 34.2 000 patient days, triple USA.
The quality of intensive care unit (ICU) nursing handover impacts patient safety, including infection prevention and control (IPC) antimicrobial stewardship (AMS) practices. We report a co-designed improvement study using visual, structured nurse tool in low resource setting. was conducted with clinical nurses an 8-bed medical ICU at tertiary hospital South Africa. Using participatory action research (PAR) framework visual methods, the development had three phases: data collection, journal...
Abstract Background Research on the contextual drivers of antimicrobial stewardship (AMS) programme interventions in neonatal units is limited. Methods As part a prospective mixed-methods multidisciplinary AMS (NeoAMS) interventional study 14 South African hospitals, we applied three-phased process to assess implementation barriers and experienced by participating health professionals. The included: (Phase one; P1) survey pre-intervention enablers; (P2) written feedback during intervention...
Abstract Hospital‐acquired antimicrobial‐resistant infections are a leading cause of neonatal mortality in South African (SA) intensive care units (NICU). There is an urgent need for NICU Antibiotic Stewardship Programs (ASP). We describe the development international Train‐the‐Trainer (TTT) NICU‐ASP mentoring program SA pharmacists. A partnership between Africa Antimicrobial Program (SAASP) and ASP experts from two United States (US) hospitals was formed 2019. baseline assessment four NICUs...
Background: The International Guidelines for Management of Severe Sepsis and Septic Shock recommend the administration effective intravenous antimicrobials within first hour recognition septic shock. With every delay in appropriate antimicrobial therapy, mortality increases by 7.6%. time from written antibiotic order to actual or "hang-time" can often be several hours due logistics hospital. Netcare (Ltd), a 54 private sector hospital system across South Africa implemented practice...