A5079823011- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Tuberculosis Research and Epidemiology
- Reproductive tract infections research
- Pneumonia and Respiratory Infections
- Urinary Tract Infections Management
- Nosocomial Infections in ICU
- Syphilis Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Mycobacterium research and diagnosis
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Antimicrobial Resistance in Staphylococcus
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Antibiotics Pharmacokinetics and Efficacy
- Family and Patient Care in Intensive Care Units
- Bacterial Infections and Vaccines
- Infectious Diseases and Tuberculosis
- Pediatric Urology and Nephrology Studies
- Gut microbiota and health
- Salmonella and Campylobacter epidemiology
- Pharmaceutical Practices and Patient Outcomes
- Viral gastroenteritis research and epidemiology
eThekwini Municipality
2025
University of KwaZulu-Natal
2016-2025
National Health Laboratory Service
2015-2025
University of Zululand
2023
Background The World Health Organization (WHO) recommends systematic symptom screening for tuberculosis (TB). However, TB prevalence surveys suggest that this strategy does not identify millions of patients, globally. Undiagnosed or delayed diagnosis contribute to transmission and exacerbate morbidity mortality. We conducted a cluster-randomized trial large urban rural primary healthcare clinics in 3 provinces South Africa evaluate whether novel intervention targeted universal testing (TUTT)...
Background. The increasing rates of antimicrobial resistance observed in the nosocomial pathogen Klebsiella pneumoniae are major public health concern worldwide. Objectives. To describe antibiotic susceptibility profiles K. isolates from bacteraemic patients submitted by sentinel laboratories five regions South Africa mid-2010 to mid-2012. Molecular methods were used detect most commonly found extended-spectrum beta-lactamase (ESBL) and carbapenemase genes. Methods. Thirteen academic centres...
Whole-genome sequence (WGS) analyses were employed to investigate the genomic epidemiology of extensively drug-resistant Klebsiella pneumoniae strains, focusing on carbapenem resistance-encoding determinants, mobile genetic support, clonal and epidemiological relationships. A total ten isolates obtained from patients admitted intensive care unit (ICU) in a public hospital South Africa. Five rectal swabs colonized five blood cultures with invasive carbapenem-resistant infections. Following...
Abstract Background Antimicrobial resistance (AMR) has emerged as a global threat to healthcare resulting in an increase morbidity and mortality. Neonatal sepsis is ranked the third highest cause of neonatal demise globally, which AMR accounted for 31.0% deaths. neonates been poorly characterised Durban, South Africa. Thus, resultant effect on empiric regimens uncertain this setting. Therefore, study analysed aetiology antimicrobial susceptibility patterns bloodstream infections within...
While tuberculosis (TB) is primarily addressed in South Africa’s public sector, people with TB also present to private sector General Practitioners (GPs), where may be missed or treatment delayed. We introduced a pilot project high-TB burden health district connect GPs free testing. aimed gauge GPs’ willingness participate and describe patterns the sector. practicing metropolitan eThekwini from May 2021-March 2022 were invited participate. Recruited provided sputum specimen jars,...
Nosocomial infections are a major cause of morbidity in the critically injured, and incidence resistant strains bacteria is increasing. Management requires strategy that achieves accurate empiric cover without antibiotic overuse - goal may be achieved by surveillance stewardship.With aim minimising use empirical ultrabroad-spectrum combination antimicrobial prescriptions reducing bacterial resistance, level I Trauma Intensive Care Unit (TICU) at Inkosi Albert Luthuli Central Hospital (IALCH)...
Abstract Introduction Antimicrobial stewardship (AMS) education and interprofessional collaboration are integral to the success of a programme. An interactive AMS workshop, designed encourage workplace was piloted in tertiary hospital. Objectives To obtain feedback determine suitability sustainability workshop. Methods Feedback elicited through predesigned questionnaire containing both open-ended closed questions on content structure Results The survey had 70% (n = 16) overall response rate....
Rifampicin resistance missed by commercial rapid molecular assays but detected phenotypic may lead to discordant susceptibility results and affect patient management.This study was conducted evaluate the causes of rifampicin GenoType MTBDRplus its impact on programmatic management tuberculosis in KwaZulu-Natal, South Africa.We analysed routine programme data from January 2014 December isolates showing assay agar proportion method. Whole-genome sequencing performed a subset these isolates.Out...
Abstract During 2016–2017, Nakaseomyces glabrata (formerly Candida glabrata) caused 14% of cases candidaemia in South Africa. We aimed to describe the clinical characteristics adults with N. at 20 sentinel hospitals (accounting for 20% (172/917) cases) and antifungal susceptibility corresponding isolates. A higher proportion patients were older (median age: 55 years [interquartile range (IQR): 41–65 years] vs. 49 [IQR: 35-63 years]; p = 0.04), female (87/164, 53% 283/671, 42%; 0.01),...
Background. Urinary tract infection (UTI) is one of the most common infections during pregnancy, which can lead to significant maternal and perinatal morbidity mortality if left untreated. Challenges when treating UTIs in pregnancy include fetal protection resistance development uropathogens. Currently, Essential Medicines List recommends nitrofurantoin treat cystitis ceftriaxone pyelonephritis pregnant women. Objectives. To determine pathogens causing UTI their antibiotic susceptibility...
Drug resistant Acinetobacter baumannii (A. baumannii) poses serious treatment challenges and is on the rise worldwide. The Infectious Diseases Society of America/Society for Healthcare Epidemiology America recommends preauthorization antibiotics to ensure successful antibiotic stewardship programs (ASWPs). This study estimates analyzes microbiological clinical characteristics A. baumanii strains with differentiating criteria sepsis versus colonization, in order support assist ASWPs at...
Ventilator-associated pneumonia (VAP) has recently been classified as possible or probable. Although direct attributable mortality difficult to prove, delay in instituting appropriate therapy reported increase morbidity and mortality. Recent literature suggests that VAP, directed while awaiting microbiological culture does not prejudice outcome compared with best-guess empirical therapy.To ascertain outcomes of v. probable respectively.Endotracheal aspirates were obtained from patients...
Abstract Background Invasive meningococcal disease (IMD) is endemic to South Africa, where vaccine use negligible. We describe the epidemiology of IMD in Africa. Methods cases were identified through a national, laboratory-based surveillance program, GERMS-SA, from 2003–2016. Clinical data on outcomes and human immunodeficiency virus (HIV) statuses available 26 sentinel hospital sites. conducted space-time analyses detect clusters serogroup-specific cases. Results Over 14 years, 5249...
Background. In South Africa (SA), the National Department of Health has developed an Antimicrobial Resistance Strategy Framework document to manage antimicrobial resistance (AMR). One strategic objectives is optimise surveillance and early detection AMR. At Institute for Communicable Diseases (NICD), analysis selected organisms agents from both public private sectors was conducted. Objectives. The relevance AMR increasingly recognised in light global action plans combat resistance. this...
Antimicrobial stewardship programmes (ASPs) facilitate appropriate antimicrobial use and require contextualization for optimal functioning. We aimed to investigate perceptions of resistance (AMR) ASPs among healthcare workers in academic nonacademic hospitals.Cross-sectional survey.Three (Charlotte Maxeke Johannesburg Academic, Inkosi Albert Luthuli, Tygerberg) three hospitals (Leratong, Prince Mshiyeni Memorial, Paarl) South Africa from January June 2022.Doctors, nurses,...
Vancomycin resistant enterococci (VRE) are increasingly important causes of morbidity and mortality in developed countries. Although VRE is a significant cause nosocomial sepsis these countries, limited data available on the role that this pathogen plays South Africa. We describe demographic, clinical genotypic seven patients involved first outbreak haematology unit at tertiary hospital Durban also report isolation from six other wards hospitals outside Durban. The occurred 19 April 2011 to...
There is a lack of data on the burden Chlamydia trachomatis and Neisseria gonorrhoeae among human immunodeficiency virus- (HIV-) infected pregnant women in South Africa. We conducted cross-sectional study which included 385 HIV-infected attending antenatal clinic at King Edward VIII Hospital Durban, The provided vaginal swabs were tested for C. N. gonorrhoeae. prevalence individual STIs was as follows: (47/385, 12.2%) (16/385, 4.1%). Having circumcised partner, testing positive gonorrhoeae,...
Introduction: Antimicrobial resistant bacterial infections are widespread globally and increases in antimicrobial resistance presents a major threat to public health. Pseudomonas aeruginosa is an opportunistic healthcare-associated pathogen with high rates of morbidity mortality extensive range mechanisms. This study describes the antibiotic susceptibility profiles P. isolates from patients bacteraemia submitted by sentinel laboratories South Africa 2014 2015.
 Methodology: Organism...
Staphylococcal infections can cause significant morbidity in patients undergoing dialysis. This study evaluated the effects of HIV infection on nasal carriage Staphylococcus aureus, staphylococcal peritonitis, and catheter rates with end-stage renal failure managed continuous ambulatory peritoneal dialysis (CAPD).Sixty HIV-positive 59 HIV-negative CAPD were enrolled followed up for to 18 months. S. aureus (detected by swab culture), peritonitis (diagnosed clinical presentation, effluent...