A5051423902- Stroke Rehabilitation and Recovery
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Cerebral Palsy and Movement Disorders
- HIV-related health complications and treatments
- Tuberculosis Research and Epidemiology
- Adolescent Sexual and Reproductive Health
- Bone fractures and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Healthcare Policy and Management
- Cystic Fibrosis Research Advances
- Healthcare cost, quality, practices
- HIV/AIDS drug development and treatment
- Spinal Cord Injury Research
- Pneumonia and Respiratory Infections
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Global Maternal and Child Health
- Craniofacial Disorders and Treatments
- Cancer Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- Veterinary Equine Medical Research
- Dementia and Cognitive Impairment Research
- Dental Radiography and Imaging
- Tracheal and airway disorders
South African Medical Research Council
2015-2024
Medical Research Council
2007-2015
University of Pretoria
2010
University of Cape Town
2010
Human Sciences Research Council
2010
Objective. As sub-Saharan Africa is highly endemic for hepatitis B virus (HBV) and human immunodeficiency (HIV) infections, their co-infection requires special management, we aimed to assess the serological molecular characteristics of HBV in patients with AIDS. Design. This was a cross-sectional, case control study, which enrolled 200 AIDS HIV-negative controls. serology done all participants HCV core antibody (anti-HBc) only pattern. Nested polymerase chain reaction (PCR) viral load assays...
Perinatal deaths account for 7% of the global burden disease, with developing countries contributing about 98% deaths. The aim this study was to describe prevalence and factors adverse pregnancy outcomes, particularly perinatal death, among women at Sakubva hospital, Mutare district, Zimbabwe from January June 2014. We conducted a retrospective review 346 patient records, who delivered hospital those referred district facilities Provincial Hospital, between Descriptive statistics used...
Cytomegalovirus (CMV) infection is associated with severe diseases in immunosuppressed patients; however, there a lack of data for pre-emptive therapy patients HIV/AIDS.This was retrospective study, which enrolled diagnosed HIV/AIDS (CD4<200 cells/μl), who had detectable CMV viral load (VL) during their stay an adult medical intensive care unit between 2009-2012.After screening 82 patients' records, 41 met the enrolment criteria. Their median age 37 (interquartile range [IQR]: 31-46), and...
Background: Self-efficacy and medication beliefs are known factors that influence adherence to treatment in chronic medical conditions. We carried out a cross-sectional study on human immunodeficiency virus (HIV)-infected patients with the aim of determining predictive relationship between these two variables antiretroviral therapy (ART) at health facility Pretoria.Method: Participants' were assessed using Beliefs about Medicines Questionnaire. was evaluated HIV Adherence Self-Efficacy...
Mutations causing mono and cross-resistance among amikacin, kanamycin capreomycin of second-line injectable drugs (SLIDs) namely are not well understood. We investigated 124 isolates Mycobacterium tuberculosis for mutations within rrs, eis, tlyA efflux pump (Rv1258c Rv0194) genes involved in resistance towards SLIDs. The distribution across these were significantly different strains with mono-resistance or cross-resistance. A new mutation G878A was found rrs gene, mono-resistant,...
Background Two thirds of the world's new HIV infections are in sub-Saharan Africa. Acute infection (AHI) is time virus acquisition until appearance antibodies. Early infection, which includes AHI, interval between and establishment viral load set-point. This study aimed to detect acute early a hyper-endemic setting. Methods was cross-sectional diagnostic that enrolled individuals who had negative rapid results five clinics South Pooled nucleic acid amplification testing (NAAT) performed,...
Pregnant women are especially at risk of developing complications when infected with reproductive tract infections (RTIs). The objective this study was to determine the prevalence bacterial vaginosis (BV) and genital mycoplasmas in pregnant investigate associations between BV, mycoplasmas, HIV infection, age gestational age.Cross-sectional descriptive analytical components.Antenatal clinic a tertiary academic hospital South Africa.220 older than 18 were included provided self-collected...
Background. People with spinal cord injury (PWSCI) face various challenges after being discharged from rehabilitation that can result in readmission to hospital. Little is known about of PWSCI South Africa (SA). Readmission costly, interrupts community involvement and negatively affects quality life. Objectives. To investigate rates within 5 years rehabilitation, causes factors related Pretoria, SA. Methods. We quantitatively analysed retrospective data gathered files patients admitted a...
The objective of this study was to evaluate the effect a commercial feed supplement containing pectin-lecithin on squamous mucosa ulceration in horses exposed an experimental model. Five mares were treated while five controls for crossover, blinded study. fed concentrates and hay stabled with two-hour turn out per day period four weeks. complex duration group. At end four-week period, all underwent seven-day alternating deprivation (week 5). repeated again after washout period. Gastroscopy...
Spinal cord injuries result in devastating impairments that can produce severe functional limitations. However, few documented studies have investigated the levels of function and factors influence ability at discharge from in-patient rehabilitation facilities Gauteng following such injuries. This necessitated further investigation.Fifty participants were recruited for this cross-sectional, observational study. Participants one private government spinal unit Gauteng. A custom-developed...
The psychological impact of the South African border war on veterans has received little or no attention. This study determined prevalence post-traumatic stress disorder (PTSD), and extent resilience among a cohort veterans.Of 1527 former students who matriculated from Johannesburg high school 1975 to 1988, only 109 were reachable for convenience snowballing recruitment into this study. An anonymous, internet-based questionnaire was used obtain information demography, combat exposure, drug...
Objectives: This study explored major factors that influenced staff motivation at a district hospital in South Africa following reforms and comparison of these across the two main categories.Design: was cross-sectional descriptive survey.Settings subjects: included all medical nursing working hospital.Outcome measures: A semi-structured questionnaire coded for anonymity used. It comprised three sections: introduction, demographic information list to which participants responded by indicating...
Background. Pneumococcal carriage studies provide a baseline for measuring the impact of pneumococcal conjugate vaccines (PCVs). The advent has led to reductions in vaccine serotypes (VTs) carriage. However, increasing non-vaccine (NVTs) remain significant concern, necessitating continued surveillance 13-valent PCV (PCV13) era. Objectives. To investigate carriage, serotype distribution and risk factors colonisation among children presenting routine immunisation at two clinics Gauteng...
To assess and compare the extent of high-risk drinking factors associated with in adult female population a rural an urban region South Africa.Cross-sectional household survey using multistage sampling methods. Setting. A wine farming area Western Cape site Gauteng. Subjects. Women reproductive age (18 - 44 years). Outcome measures. The risky alcohol consumption measured Alcohol Use Disorders Identification Test (AUDIT) scale which categorises current drinkers into high- low-risk...
Insufficient information exists on comparing radiological differences in bone density of the regeneration rate alveolar maxilla and mandible following creation similar defects both. Alveolar were created from five healthy Chacma baboons. Standardized x-ray images acquired over time densities selected defect areas measured pre-operatively, directly post-operatively at three- six weeks post-operatively. Differences statistically tested using ANOVA. The was significantly more radiologically...
Background: A general non-specific marker of disease activity that could alert the clinician and prompt further investigation would be value in patients with HIV/AIDS, especially resource limited environments.Objective: To investigate potential neopterin as biomarker advanced HIV/AIDS.Methods: Cross-sectional study 105 HIV positive (75 on highly active antiretroviral treatment (HAART). Neopterin was assessed by enzyme linked immune-absorbent assay cytokines flow cytometry.Results: levels...