A5048644412- Hemoglobinopathies and Related Disorders
- Viral-associated cancers and disorders
- Parvovirus B19 Infection Studies
- Iron Metabolism and Disorders
- Cytomegalovirus and herpesvirus research
- Blood groups and transfusion
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Blood donation and transfusion practices
- Prenatal Screening and Diagnostics
- Folate and B Vitamins Research
- Biological Research and Disease Studies
- HIV-related health complications and treatments
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Statistical Methods in Clinical Trials
- Identification and Quantification in Food
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Vibrio bacteria research studies
- Multiple Myeloma Research and Treatments
- Advanced Causal Inference Techniques
University Teaching Hospital
2003-2024
University of Zambia
2018
University of Nebraska–Lincoln
2001
Istituto Superiore di Sanità
1999
University of Rome Tor Vergata
1999
Infectious Diseases Institute
1999
Alexandria University
1999
Little is presently known about the specific routes of transmission Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8). To investigate whether this agent might be transmitted vertically from mother to infant, we conducted a study on 89 KSHV seropositive mothers and their newborn infants. Thirteen (14.6%) had DNA detected in peripheral blood mononuclear cells (PBMC). Two samples drawn at birth infants born detectable within PBMC. These findings suggest that can...
Background: HIV infection has been associated with an increased risk of non-Hodgkin lymphoma, particularly in the first world. Despite high burden sub-Saharan regions, published data on and malignancies are sparse from these areas. Materials Methods: We recently lymphomas diagnosed January 2004 to December 2006, at a single center Johannesburg, serve as baseline for long-term comparison during period highly active antiretroviral therapy rollout. report retrospective analysis follow-up...
Although simple and low-cost interventions for sickle cell disease (SCD) exist in many developing countries, child mortality associated with SCD remains high, part, because of the lack access to diagnostic tests SCD. A density-based test using aqueous multiphase systems (SCD-AMPS) is a candidate low-cost, point-of-care In this paper, field evaluation SCD-AMPS large (n = 505) case-control study Zambia described. Of two variations used, best system (SCD-AMPS-2) demonstrated sensitivity 86%...
The specific route and timing of human herpesvirus (HHV) 8 infection in regions where Kaposi sarcoma is endemic are not known. HHV-8 any risk factors that may be associated with HHV-8, including immunodeficiency virus (HIV) type 1 infection, were monitored during the 12-month postdelivery period for 416 mothers 485 infants from Lusaka, Zambia. incident rates this 3.2 5.3 infections/100 person-years mothers, respectively. among was or HIV-1 mother. Among HHV-8–positive infants, 2 12 tested...
HIV infection has been associated with an increased risk of malignancy, both AIDS defining and non-AIDS defining.This study presents a detailed pathological description newly diagnosed lymphomas in Johannesburg, South Africa (January 2004 December 2006). The review coincides introduction combination antiretroviral therapy.One thousand eight hundred ninety-seven new lymphoproliferative disorders were referred to the Charlotte Maxeke Johannesburg Academic Hospital. B-cell non-Hodgkin lymphoma...
Sickle cell disease is a group of hemoglobin (Hb) disorders resulting from the inheritance sickle β-globin gene. It most common pathological Hb mutation worldwide with 75% being born in Sub-Saharan Africa.This study aims to determine if dried blood spots (DBSs) can be used for diagnosis newborns. In Zambia, there no neonatal screening program anemia (SCA), yet it has been proved that early by newborn (NBS) using DBSs and access comprehensive care results survival adulthood over 96%...
Sickle cell anaemia (SCA) is an inherited disease resulting from mutations in the β -globin chain of adult haemoglobin that results formation homozygous sickle haemoglobin. It associated with several complications including altered blood picture and damage multiple organs, kidneys. Kidney seen most patients SCA may affect glomerular and/or tubular function, thereby putting these at risk urinary tract infections. However, there a paucity data on prevalence infections (UTIs) among Zambia. This...
Background: Multiple myeloma (MM) is the second most common blood cancer after lymphomas, thereby accounting for 10% of all haematological malignancies.Objectives: To evaluate clinical and radiological features Myeloma at presentation in patients presenting University Teaching Hospital (UTH), Lusaka, Zambia.Design: Descriptive studyMethods Results: Record files diagnosed with MM from 2008-2015 April were reviewed. Data was analysed using SPSS Version 22. The median age diagnosis 53.0 (range...
Macrocytic anemia is frequently observed in adult HIV-infected patients treated with nucleoside reverse transcriptase inhibitors and vitamin B12 folate deficiency. In this case report, we discuss a 52-year-old nonvegetarian male on long-term antiretroviral therapy for 5 years, presenting severe macrocytic (hemoglobin, 3.7 g/dL; mean corpuscular volume, 119.6 fL) leukopenia (2.71∗109/L), who was diagnosed megaloblastic caused by deficiency following laboratory investigations. Parenteral...
Little is presently known about the specific routes of transmission Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8).To investigate whether this agent might be transmitted vertically from mother to infant, we conducted a study on 89 KSHV seropositive mothers and their newborn infants.Thirteen (14.6%) had DNA detected in peripheral blood mononuclear cells (PBMC).Two samples drawn at birth infants born detectable within PBMC.These findings suggest that can...
Abstract Of the 500 000 children born with sickle cell disease annually, most cases occur in Africa, contributing to significant morbidity and mortality associated limited (SCD) health outcomes data reduced access therapeutic plus preventive care. We aim develop manage a standardized electronic SCD registry, establish consistent standards of care (SoC) for patients, improve research biobanking capacity Zimbabwe Zambia. This five-year program employs mixed methods that include infrastructure...
Abstract Objectives Vibrio cholerae remains a significant public health threat in Africa, with antimicrobial resistance (AMR) complicating treatment. This study leverages whole-genome sequencing (WGS) of V. isolates from Côte d’Ivoire, Ghana, Zambia and South Africa to assess genomic diversity, AMR profiles, virulence, demonstrating the utility WGS for enhanced surveillance within PulseNet network. Methods We analysed clinical environmental sources (2010–2024) using Oxford Nanopore hybracter...
Chromosomal aberrations play a significant role in the pathogenesis of acute lymphoblastic leukemia (ALL) with prognostic and therapeutic implications. Despite availability molecular tools, low-resource settings struggle to diagnose disease due limited diagnostic capacity. The objective this study was detect common chromosomal patients ALL attending University Teaching Hospital (UTH) Lusaka, Zambia.In prospective study, 19 blood samples from were screened for presence BCR-ABL, E2A-PBX1,...
Objectives - The objectives of the study were to compare plasma levels IL-6 in HIV positive and negative individuals correlate them with CD4 count
 Materials methods A cross-sectional was carried out at University Teaching Hospital Lusaka, Zambia. assessed on ART, ART- naïve control participants.
 Results Conclusion Our showed that ART participants had higher concentrations (2.83 ± 1.60 ng/ml) than those (2.49 1.21 p = 0.020. however, (3.24 1.33 1.21) 0.002. therefore, highest...
Abstract Anaemia is a condition in which either the number of red blood cells or their oxygen-carrying capacity insufficient to meet physiologic needs, vary by age, sex, altitude, smoking and pregnancy status. The global estimate childhood anaemia indicates that 293.1 million children are anaemic, 28.5% these reside sub-Sahara Africa. Also, significant public health problem with high age-standardised death rate 11.18 per 100,000 Zambia. We conducted cross-sectional study involving 392...
Andreoni, Massimo; El-Sawaf, Gamal*; Rezza, Giovanni**; Ensoli, Barbara***; Nicastri, Emanuele; Ventura, Laura; Ercoli, Lucia; Sarmati, Loredana; Rocchi, Giovanni Author Information