A5075958016- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Parasites and Host Interactions
- Cancer Genomics and Diagnostics
- Parasite Biology and Host Interactions
- Pneumonia and Respiratory Infections
- Antibiotic Use and Resistance
- Helminth infection and control
- Iron Metabolism and Disorders
- Chronic Kidney Disease and Diabetes
- COVID-19 Pandemic Impacts
- Hemoglobinopathies and Related Disorders
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- COVID-19 epidemiological studies
- Endometrial and Cervical Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- Infectious Diseases and Mycology
- Acute Kidney Injury Research
- Renal cell carcinoma treatment
- Blood groups and transfusion
- CNS Lymphoma Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
- Neurological and metabolic disorders
- COVID-19 diagnosis using AI
University of Zambia
2016-2025
Centre for Infectious Disease Research in Zambia
2024
Copperbelt University
2020-2021
University Teaching Hospital
2018
Irrational and inappropriate prescribing of antibiotics is a major problem that can lead to the development antimicrobial resistance (AMR). In Zambia, there insufficient information on patterns according World Health Organization (WHO) AWaRe classification. Therefore, this study assessed using classification during COVID-19 pandemic at University Teaching Hospital in Lusaka, Zambia. A cross-sectional was conducted 384 patient medical files from August 2022 September 2022. All were classified...
Background: The irrational use of medicines remains a key health problem in many developing countries. overuse antibiotics is driver antimicrobial resistance (AMR). This study surveyed antibiotic and adherence to the World Health Organization (WHO) prescribing indicators at Request Muntanga Hospital Kalomo District Southern Province, Zambia. Materials Methods: cross-sectional was conducted from July 2023 September Zambia reviewed 600 medical record prescriptions which were issued 1, 2022...
Drug-resistant tuberculosis has continued to be a serious global health threat defined by complexity as well higher morbidity and mortality wherever it occurs, Zambia included. However, the paucity of information on drug-susceptibility patterns both first-line second-line anti-tuberculosis (anti-TB) drugs, including new repurposed drugs used in management drug-resistant Zambia, was major thrust for conducting this study.A total 132 bacteriologically confirmed TB isolates were collected from...
Antimicrobial resistance (AMR) is an emerging challenge to global public health. The use of antibiotics in the veterinary field one contributing factors AMR mostly due poor knowledge, attitudes, and practices (KAP) dispensers. Veterinary drug dispensers are expected guide clients on indications, contraindications, withdrawal periods drugs. This study assessed dispensers’ KAP toward associated potential factors. A cross-sectional study, using a structured questionnaire, was conducted three...
Background: Bovine tuberculosis (bTB) is a disease of cattle that transmitted through direct contact with an infected animal or ingestion contaminated food. Methods: A mixed methods study was conducted in two districts Zambia Lundazi and Monze from December 2021 to June 2022. cross-sectional survey 280 respondents, five focus group discussions, key informant interviews. Descriptive statistics were used analyze quantitative data using R software while qualitative analyzed Nvivo® content...
The malignant phenotype of tumour cells is fuelled by changes in the expression various transcription factors, including some well-studied proteins such as p53 and Myc. Despite significant progress made, little known about several other ELF4, how they help shape oncogenic processes cancer cells. To this end, we performed a bioinformatics analysis to facilitate detailed understanding variations ELF4 human cancers are related disease outcomes cell drug responses. Here, using mRNA data 9,350...
Pancreatic cancer remains a significant public health problem with an ever-rising incidence of disease. Cancers the pancreas are characterised by various molecular aberrations, including changes in proteomics and genomics landscape tumour cells. Therefore, there is need to identify proteomic pancreatic specific genomic alterations associated disease subtypes. Here, we carry out integrative bioinformatics analysis The Cancer Genome Atlas dataset, whole-exome sequencing data collected from...
The diagnosis and evaluation of impaired renal function remains a challenge owing to lack reliable biomarker for assessment kidney function. existing panel biomarkers currently displays several limitations, recently injury molecule-1 (KIM-1) has been suggested as sensitive proposed enter clinical practice.This study was conducted determine the diagnostic value serum creatinine, urea, microalbuminuria (MAU) in relation novel biomarker, KIM-1.Serum MAU, KIM-1 were measured forty individuals...
Sickle cell disease is a group of hemoglobin (Hb) disorders resulting from the inheritance sickle β-globin gene. It most common pathological Hb mutation worldwide with 75% being born in Sub-Saharan Africa.This study aims to determine if dried blood spots (DBSs) can be used for diagnosis newborns. In Zambia, there no neonatal screening program anemia (SCA), yet it has been proved that early by newborn (NBS) using DBSs and access comprehensive care results survival adulthood over 96%...
Background Zambia like many countries in sub-Saharan Africa is affected with drug resistant tuberculosis. However, the tuberculosis situation over years has not been described various regions of country. Consequently, this study aims to determine burden northern a four-year period based on data generated from Regional Tuberculosis Reference Laboratory. Method Two hundred and thirty two (232) Drug Susceptibility Testing results (2016-2019) were reviewed. Data was collected registers patient...
Abstract Since the earliest reports of Coronavirus disease - 2019 (COVID-19) in Wuhan, China December 2019, has rapidly spread worldwide, attaining pandemic levels early March 2020. However, COVID-19 differed African setting compared to countries on other continents. To predict Africa and within each country continent, we applied a Susceptible-Infectious-Recovered mathematical model. Here, our results show that, overall, is currently (July 24, 2020) at peak pandemic, after which number cases...
Introduction: kidney injury affects renal excretion of plasma analytes and metabolic waste products with grave pathologic consequences. Early detection, thus is essential for specific intervention that may avert permanent damage delay progression injury. We aimed to evaluate Kidney Injury Molecule-1 (KIM-1) Microalbuminuria (MAU), as biomarkers injury, in comparison creatinine.
Sickle cell anaemia (SCA) is an inherited disease resulting from mutations in the β -globin chain of adult haemoglobin that results formation homozygous sickle haemoglobin. It associated with several complications including altered blood picture and damage multiple organs, kidneys. Kidney seen most patients SCA may affect glomerular and/or tubular function, thereby putting these at risk urinary tract infections. However, there a paucity data on prevalence infections (UTIs) among Zambia. This...
Schistosomiasis remains a public health concern in Zambia. Urinary schistosomiasis caused by Schistosoma haematobium is the most widely distributed infection. The aim of current study was to determine prevalence and risk factors urinary identify strain S. among children Siavonga Lusaka districts Urine samples were collected from 421 primary school eggs examined under light microscopy. A semi-structured questionnaire used obtain information on socio-demographic characteristics potential for...
Abstract Cervical cancer has remained the most prevalent and lethal malignancy among women worldwide accounted for over 250,000 deaths in 2019. Nearly ninety-five per cent of cervical cases are associated with persistent infection high-risk Human Papillomavirus (HPV), seventy these viral integration host genome. HPV-infection imparts specific changes regulatory network infected cells that diagnostic, prognostic importance. Here, we conducted a systems-level analysis changes, proteins...
Abstract Pancreatic cancer remains a significant public health problem with an ever-rising incidence of disease. Cancers the pancreas are characterised by various molecular aberrations, including changes in proteomics and genomics landscape tumour cells. There is need, therefore, to identify proteomic pancreatic specific genomic alterations associated disease subtypes. Here, we carry out integrative bioinformatics analysis The Cancer Genome Atlas dataset that includes whole-exome sequencing...
The prevalence of nontuberculous mycobacteria (NTM) infections and disease is rising worldwide due to increased research, diagnostics capabilities, awareness the disease. There limited data for NTM from different sources in Zambia. aim this study was determine species distribution at human–livestock–environment interface. A cross-section conducted Namwala, Chipata, Lundazi Districts Zambia April 2020 December 2021. Sputum samples were collected tuberculosis presumptive patients health...
We aimed to assess the proportion of tuberculosis in humans and (TB)-associated abattoir condemnations from animal sector, as well determine risk factors zoonotic at animal-human interface Zambia. The study involved 255 presumptive TB patients 156 cattle carcasses was conducted April 2020 December 2021. Univariable multivariable logistic regressions were performed for factor analysis TB. overall bovine traditional among 39.7% 10.2%, respectively. Consumption raw milk (adjusted odds ratio...
Salmonella infections are a public health problem across the globe. In South Sudan, there is little information regarding prevalence and antibiotic resistance patterns of Salmonella. Therefore, this study assessed antimicrobial susceptibility isolates from chickens humans in Sudan. Fecal samples were collected cultured on Xylose Lysine Deoxycholate Agar for isolation confirmed using biochemical tests PCR through amplification invA gene. A total 417 fecal examined, which 270 (64.7%) chicken...
Since the earliest reports of Coronavirus disease - 2019 (COVID-19) in Wuhan, China December 2019, has rapidly spread worldwide, attaining pandemic levels early March 2020. However, COVID-19 differed African setting compared to countries on other continents. To predict Africa and within each country continent, we applied a Susceptible-Infectious-Recovered mathematical model. Here, our results show that, overall, is currently (May 29, 2020) at peak pandemic, after which number cases would...
ABSTRACT Introduction Lifestyle-related diseases like type 2 diabetes mellitus, have emerged as a significant public health problem due to rapid urbanization and industrialization. In 2018, the prevalence of mellitus was estimated be 500 million cases worldwide comparable between high- low-income countries. Diabetes leads multiple complications, including end-stage renal disease, cardiovascular infection, death. Anaemia in diabetic individuals has severe adverse effects on quality life is...
The malignant phenotype of tumour cells is fuelled by changes in the expression various transcription factors, which include some well-studied proteins such as p53 and Myc. Despite significant progress made, little known about several other including ELF4, how they help shape oncogenic processes that occur cancer cells. To this end, we performed a bioinformatics analysis to facilitate detailed understanding transcriptional variations ELF4 human cancers are related disease outcomes cell drug...