A5024940958- HIV/AIDS Research and Interventions
- T-cell and Retrovirus Studies
- HIV, Drug Use, Sexual Risk
- HIV-related health complications and treatments
- HIV Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Long-Term Effects of COVID-19
- HIV/AIDS drug development and treatment
- Health and Medical Education
- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- Viral-associated cancers and disorders
- Pharmacogenetics and Drug Metabolism
- Public Health and Environmental Issues
- COVID-19 and Mental Health
- Viral Infections and Immunology Research
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Liver Disease and Transplantation
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Medical Imaging and Pathology Studies
- Lymphoma Diagnosis and Treatment
- Aortic aneurysm repair treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Instituto de Medicina Tropical
2019-2025
Universidad Peruana Cayetano Heredia
2014-2024
Hospital Nacional Cayetano Heredia
2014-2023
Hospital Christus Muguerza Alta Especialidad
2023
World Health Organization
2022
National University of San Marcos
2022
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2019
Vanderbilt University
2019
Fundacion Arriarán
2019
University of Chile
2019
Introduction Peru is among the top ten countries with highest number of coronavirus disease 2019 (COVID-19) cases worldwide. The aim study was to describe clinical features hospitalized adult patients COVID-19 and determine prognostic factors associated in-hospital mortality. Methods We conducted a retrospective cohort admitted Hospital Cayetano Heredia; tertiary care hospital in Lima, Peru. primary outcome Multivariate Cox proportional hazards regression used identify independently Results...
Abstract Background COVID-19 survivors overcome long-lasting symptoms that affect their quality of life (QoL). We assessed the impact on QoL and factors associated with persistence reversibility poor 6 months after acute COVID 19. Methods enrolled symptomatic patients who tested positive for SARS-COV-2 an antigenic or RT-PCR test between August 2021 October 2022. classified subjects according to disease severity: B1 (mild: outpatient), B2 (moderate: outpatient pneumonia), B3 (severe:...
Late presentation to care and antiretroviral therapy (ART) initiation with advanced human immunodeficiency virus (HIV) disease are common in Latin America. We estimated the impact of these conditions on mortality region. included adults enrolled during 2001-2014 at HIV clinics. adjusted attributable risk (AR) population fraction (PAF) for all-cause (advanced LP), ART disease, not initiating ART. Advanced was defined as CD4 <200 cells/μL or acquired immune deficiency syndrome. AR PAF were...
The COVID-19 pandemic has deeply affected the national health system in Peru, and despite many strategies implemented to control epidemic, collapse of sanitary was imminent. We performed a retrospective cohort from clinical records adult patients with admitted Hospital Cayetano Heredia (Lima, Peru), between March June 2020. A total 369 patient charts were included for analysis; 241 (65.31%) male median age 59 years (IQR: 49-68). Most (68.56%) reported at least one comorbidity; more...
Abstract Introduction Immune reconstitution following antiretroviral therapy (ART) initiation is crucial to prevent AIDS and non‐AIDS‐related comorbidities. Patients with suppressed viraemia who fail restore cellular immunity are exposed an increased risk of morbidity mortality during long‐term follow‐up, although the underlying mechanisms remain poorly understood. We aim describe clinical outcomes factors associated worse immune recovery all‐cause in people living HIV (PLWH) from Latin...
Background While national adoption of universal HIV treatment guidelines has led to improved, timely uptake antiretroviral therapy (ART), longer-term care outcomes are understudied. There is little data from real-world service delivery settings on patient attrition, viral load (VL) monitoring, and suppression (VS) at 24 36 months after initiation. Methods findings For this retrospective cohort analysis, we used observational 25 countries in the International epidemiology Databases Evaluate...
The highly active antiretroviral therapy (HAART) has altered the course of HIV infection, transforming it from a fatal illness to chronic condition, reducing morbidity and mortality. However, this led an increased incidence metabolic problems such as insulin resistance, dyslipidemia, lipodystrophy impaired glucose metabolism. objectives study are determine prevalence resistance (IR) in cohort human immunodeficiency virus (HIV)-infected patients on investigate potentially associated...
A growing population of older adults with HIV will increase demands on HIV-related healthcare. Nearly a quarter people receiving care for in Latin America are currently 50 years or older, yet little is known about the frequency comorbidities this population. We estimated prevalence and incidence non-communicable diseases (NCDs) among age (≥50yo) during 2000-2015 six centers affiliated Caribbean, Central South American network epidemiology (CCASAnet).We annual prevalence, overall...
La pandemia por la COVID-19 y las medidas restrictivas de distanciamiento social pueden interactuar con epidemia VIH múltiples formas. Existen aproximadamente 87 000 personas viviendo (PVV) en el Perú quienes están riesgo contraer COVID-19; 67 ellas que reciben tratamiento antirretroviral (TAR) podrían tener limitaciones acceso a sus medicamentos, comprometiendo su adherencia salud. Además, efecto podría salud mental PVV aún no está esclarecido. Este artículo tiene como finalidad describir...
Warfarin is the most prescribed oral anticoagulant worldwide. Because of complexity warfarin therapy, we attempted to dissect genetic from bioenvironmental factors influencing dose responses in individuals a isolate Hispanic ancestry. A total 191 patients with standard values international normalized ratio were recruited. Three groups significantly different response identified, that is, sensitive (2.28 ± 0.50 mg/d), intermediate (4.2 0.76 and resistant (7.40 1.54 mg/d; Tukey test, P <...
Accelerating antiretroviral therapy (ART) administration, improving retention, and achieving viral suppression in low- middle-income countries must be prioritized. We evaluated trends disparities these milestones a large Latin American cohort. Adults starting ART (ART start ) from 2003 to 2014 at Caribbean, Central, South America network for HIV epidemiology sites were assessed care cascade outcomes: CD4 cell count >200 cells/mm 3 ; retention (≥1 visit one year after ); HIV-1 RNA <200...
Vertical transmission of HTLV-1 could lead to the early development HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). This significantly affects quality life and increases morbimortality.To describe epidemiological clinical characteristics patients with early-onset HAM/TSP, defined as disease onset before 20 years age.This is a retrospective study from an cohort between 1989 2019. We searched for medical records (1) diagnosis infection using two ELISA and/or one Western...
Abstract We aimed to quantify the proportion of people receiving care for HIV-infection that are 50 years or older (older HIV patients) in Latin America and Caribbean between 2000 2015 estimate contribution growth this population enrolled before (<50yo) after old (yo) (⩾50yo). used a series repeated, cross-sectional measurements over time Caribbean, Central South American network (CCASAnet) cohort. estimated percentage patients retained each year were patients. For every calendar year, we...
Tuberculosis (TB) diagnosis in human immunodeficiency virus (HIV) positive persons is difficult, particularly resource-limited settings. The relationship between TB culture status and mortality HIV-positive treated for unclear.We evaluated adults at or after their first HIV clinic visit Argentina, Brazil, Chile, Honduras, Mexico Peru from 2000 to 2015. Anti-tuberculosis treatment included 2 months of isoniazid, rifampicin (RMP)/rifabutin (RBT), pyrazinamide ± ethambutol, followed by...
Introduction: Every year, more than 10 million women are diagnosed worldwide with breast cancer. Breast cancer remains the leading cause of death from malignancy in women. In Mexico about 12 Mexican die every day this disease. Glutathione S-transferase (GST) family consists a group isoenzymes involved Phase II detoxification xenobiotics by glutathione conjugation. There have been reports showing GST polymorphisms as risk factor for developing Objective: Determine if frequencies GSTT1, GSTM1...
In clinical practice, identification of a case severe asthma exacerbation prompts initiation corticosteroids. However, not all that wheezes is asthma. A 61-year-old man from the Peruvian Amazon presented with progressive dyspnea, abdominal pain, and cough for past week. His medical history was remarkable since childhood; he treated beta-agonists, ipratropium, orally administered On evaluation, febrile ill-appearing. chest examination revealed diffuse wheezing bilateral crackles. He diagnosed...
Since 2006, the Peruvian National TB program (NTP) recommends voluntary counseling and testing (VCT) for all tuberculosis (TB) patients. Responding to differential burden of both diseases in Peru, is managed peripheral health facilities while HIV referral centers. This study aims determine coverage screening among patients characteristics persons not screened. From March 2010 December 2011 we enrolled new smear-positive pulmonary adults 34 a district Lima. NTP staff offered VCT Patients with...
Due to a huge crisis extensive health services many Venezuelan people living with HIV (PLWH) had migrated abroad, including Peru where favorable laws were in place until June 2019. We describe the status and epidemiological trends of PLWH from Venezuela at an program Lima. analyzed baseline follow-up data all enrolled our January 2017 December A cross-sectional study subsample served ARV adherence context migration. Between 2017-2019 Program registered 398 PLWH, representing 20% 2018 annual...
In Peru, the estimated prevalence of human immunodeficiency virus (HIV) and T-lymphotropic virus-1 (HTLV-1) co-infection has been reported to be as high 18%. Despite endemicity HTLV-1 in few studies have assessed impact HIV/HTLV-1 co-infection. Our study compared socio-demographic clinical characteristics, mortality rates between HIV-infected co-infected patients.We reviewed medical records patients aged 18 years older belonging HIV cohorts Lima during a 30-year period: 1989-2019. Each...
Early retention in care, sex, and sexual mode of HIV acquisition has been associated with mortality risk among persons living (PLWH). We assessed whether early care mediates or modifies the association between sex PLWH on antiretroviral therapy (ART) Americas. ART-naïve, adult (≥18 years) enrolling at Caribbean, Central South America network for epidemiology (CCASAnet) Vanderbilt Comprehensive Care Clinic sites 2000–2015, starting ART, ≥1 visit after ART-start were included. was defined as...