A5028504539- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Respiratory Support and Mechanisms
- HIV, Drug Use, Sexual Risk
- Leprosy Research and Treatment
- HIV-related health complications and treatments
- Actinomycetales infections and treatment
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Viral-associated cancers and disorders
- HIV/AIDS oral health manifestations
- Bacterial Infections and Vaccines
- Antifungal resistance and susceptibility
- Infective Endocarditis Diagnosis and Management
- Autoimmune Bullous Skin Diseases
- Antimicrobial Resistance in Staphylococcus
- Nosocomial Infections in ICU
- Frailty in Older Adults
- Fungal Infections and Studies
- Tryptophan and brain disorders
Instituto Nacional de Cancerología
2024-2025
Hospital General Dr. Manuel Gea Gonzalez
2024
Centro Médico ABC
2020-2023
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2018-2023
Hospital length-of-Stay has been traditionally used as a surrogate to evaluate healthcare efficiency, well hospital resource utilization. Prolonged Length-of-stay (PLOS) is associated with increased mortality and other poor outcomes. Additionally, these patients represent significant economic problem on public health systems their families. We sought describe compare characteristics of Normal Length-of-Stay (NLOS) PLOS identify sociodemographic disease-specific factors in tertiary care...
Background Coronavirus disease 2019 (COVID-19) is a systemic that can rapidly progress into acute respiratory failure and death. Timely identification of these patients crucial for proper administration health-care resources. Objective To develop predictive score estimates the risk invasive mechanical ventilation (IMV) among with COVID-19. Study design Retrospective cohort study 401 COVID-19 diagnosed from March 12, to August 10, 2020. The development comprised 211 (52.62% total sample)...
Abstract Background Necrotizing Soft Tissue Infections (NSTI) are severe clinical entities that occur in specific contexts. Although, neutropenia related to hematological malignancies (HM) has been described relation with NSTI, there is a paucity of published data describing its course and outcome this populationTable 1.Population characteristics outcomesAll values represented N(%) unless otherwise noted an asterisk. Variables marked asterisk ( * ), median(interquartile range). LRINEC score:...
Abstract Invasive pulmonary aspergillosis (IPA) is a severe infection caused by aspergillus sp. that usually develops in patients with immunosuppression. IPA has been recently described critically ill COVID-19 (termed as COVID-associated aspergillosis, or CAPA) are otherwise immunocompetent. In order to describe the characteristics of CAPA, we conducted retrospective cohort study tertiary care center Mexico City. We included all confirmed admitted intensive unit had serum bronchoalveolar...
Describe the demographic, clinical, and biochemical characteristics of overweight or obese people with severe COVID-19 pneumonia evaluate its association mechanical ventilation requirements in a Mexican cohort.Data were obtained from medical electronic records. Patients divided three groups according to World Health Organization (WHO) classification body mass index (BMI): lean, obese. Baseline clinical course compared among these 3 groups.The study included total 355 patients confirmed...
Several studies have identified main changes in T- and B-lymphocyte subsets during chronic HIV infection, but few data exist on how these behave the initial phase of infection. We enrolled 22 HIV-infected patients acute stage infection before initiation antiretroviral therapy (ART). Patients had blood samples drawn previous to ART (T0), at 2 (T1) 12 (T2) months after initiation. quantified cellular HIV-DNA content sorted naïve effector memory CD4 T cells B-lymphocytes using an 18-parameter...
Suboptimal adherence to antiretroviral therapy (ART) in people with HIV, even during sustained viral suppression, is associated persistent inflammation, immune activation, and coagulopathy. Persistently low CD4-CD8 Ratio has been also residual a good predictor of increased risk death more widely available than inflammatory biomarkers. We tested the hypothesis that ART periods complete suppression. used Medication Possession based pharmacy registries as measure time-varying, routine care CD4...
Hepatitis C virus infection (HCV) is a major cause of co-morbidity in people living with HIV (PLWHIV). The modes HCV transmission the local population PLWHIV are still unclear. We conducted this study to identify risk factors for amongst central Mexico. enrolled HIV/HCV co-infected cases and controls receiving care two outpatient clinics Mexico City. Structured questionnaires were applied, covering demographics, history percutaneous exposures, sexual behaviors, self-reported STD recreational...
Abstract Objective To describe the frequency and clinicopathological concordance of mucocutaneous manifestations in people living with HIV (PLWH) its correlation CD4+ T lymphocyte count viral load. Methods Cross‐sectional study patients diagnosed infection who underwent skin biopsy for histopathological from 1992 to 2022. Skin diseases were categorized as opportunistic sexually transmitted infections, inflammatory dermatoses, benign cutaneous neoplasms, premalignant malignant neoplasms....
Abstract Background Kaposi sarcoma (KS) is a marker of advanced HIV disease; it still the most frequent AIDS-associated malignancy in Mexico despite universal access to antiretroviral therapy, reflecting gap early diagnosis. Methods The objectives study were describe people with KS who died within 30 days admission at INCan (National Cancer Institute) and quantify resources years life lost (YLL). We collected demographic data, HIV-related variables, all diagnostic therapeutic procedures,...
Objectives Early initiation of antiretroviral therapy ( ART ) during acute HIV infection is associated with favourable clinical and epidemiological outcomes. Barriers to prompt treatment limit the benefits universal access in Mexico. We sought create an algorithm for immediate detection patients infection. Methods A nationwide cohort was created 2015. In order identify cases treat them promptly at our centre, interdisciplinary group coordinated through instant‐messaging tool using smart...
To assess the effect of protease inhibitor (PI)-based dual therapy on CD4/CD8 ratio during first year in antiretroviral (ART)-naïve patients using data from randomized controlled clinical trials.We pooled GARDEL and ANDES studies, both trials that recruited ART-naïve people living with HIV randomly assigned them to receive PI-based (DT) or triple (TT) aiming compare viral efficacy. We compared median ratios proportion > 1 at 48 weeks after ART initiation treatment arms Mann-Whitney U-test χ2...
We present a cohort of individuals who reached CD4+ T cell counts greater than 1,000 cells/mm3 (Hypers) after starting antiretroviral treatment (ART) and compared them with those between 350 999 (Concordants). Demographic data, immune recovery kinetics, subset phenotypes, integrated HIV DNA were analyzed. Data from living on their first ART regimen 48 months follow-up obtained. Immune phenotype by Flow Cytometry analysis whole blood was performed, cytokines measured, HIV-1 measured...
Abstract Background Dual therapy has emerged as a novel concept for HIV treatment. The ARTE study was aimed at comparing nucleoside-sparing dual regimen consisting of ATV/r + RAL (DT) vs standard TDF/FTC (TT) among individuals failing first NNRTI-containing Methods Randomized multicenter open-label pilot study. Primary outcome: proportion subjects with plasma HIV-1 RNA below the limit detection (<50 copies/mL) 48 weeks (W48). Secondary outcomes: discontinuation due to adverse events...

 Antecedentes: La terapia dual ha surgido como un nuevo concepto para el tratamiento del VIH. Este estudio tenía objetivo comparar régimen basado en ATV/r + RAL (TD) frente a estándar de tres drogas con TDF/FTC (TT) luego fracaso primer esquema ba- sado INNTR.ClinicalTrials.gov, Número: NCT01829802. Método: Estudio piloto abierto, multicéntrico y aleatoriza- do. Resultado primario: proporción sujetos ARN VIH-1 menor 50 copias/mL semana 48 (S48). Resulta- dos secundarios:...
ARV treatment (ART) administered during acute HIV-infection presents several immunological benefits leading to a better CD4+ T-cell recovery and diminished HIV reservoir. Patients with HIV-infection, enrolled in the VIHIA cohort, had blood samples taken at diagnosis 2, 6 12 months after ART initiation. Flow-cytometry analysis was performed fresh whole blood. Naïve-(Nv), central memory (CM), effector (EM) terminally differentiated T-cells (TMRA), as well activation markers were defined using...
Syphilis has increased among people living with HIV (PLWH), particularly in men who have sex (MSM). screening test should be routinely offered as part of comprehensive care for PLWH. We assessed the annual frequency syphilis testing and positive results patients actively receiving Mexico City its associated factors. retrospectively analyzed cohort data our clinic (2001–2017). estimated proportion PLWH that was tested prevalence infection those tested. performed annual, cross-sectional...
A 56 year-old woman presented with new onset focal seizure a history of bronchiectasis. Brain abscess was diagnosed by magnetic resonance. She confirmed to be immunocompetent and had histoplasmosis, tuberculosis, infective endocarditis ruled out. Nocardia sp. isolated from the brain identified as abscessus complex 16S rRNA sequencing. discharged on trimethoprim/sulfamethoxazole. is cause abscesses in patients underlying pulmonary structural disease like identification paramount importance it...
A 56 year-old woman presented with new onset focal seizure a history of bronchiectasis. Brain abscess was diagnosed by magnetic resonance. She confirmed to be immunocompetent and had histoplasmosis, tuberculosis, infective endocarditis ruled out. Nocardia sp. isolated from the brain identified as abscessus complex 16S rRNA sequencing. discharged on trimethoprim/sulfamethoxazole. is cause abscesses in patients underlying pulmonary structural disease like identification paramount importance it...