A5056272703- Immune Cell Function and Interaction
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Hepatitis B Virus Studies
- Immune Response and Inflammation
- Reproductive System and Pregnancy
- Hepatitis C virus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- HIV/AIDS drug development and treatment
- Cell death mechanisms and regulation
- Autoimmune and Inflammatory Disorders Research
- IL-33, ST2, and ILC Pathways
- Rabies epidemiology and control
- Toxoplasma gondii Research Studies
- Chronic Lymphocytic Leukemia Research
- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Ocular and Laser Science Research
- Virology and Viral Diseases
- Liver Disease Diagnosis and Treatment
Institut Pasteur
2014-2024
Inserm
1988-2023
Université Paris-Saclay
2023
Université Paris Cité
1987-2023
La Ligue Contre le Cancer
2023
Department of Virology
2008-2014
Institut Pasteur de Lille
2007
Université de Lille
2007
Bipar
1993-2003
Centre National de la Recherche Scientifique
1987-2001
Abstract We addressed the role of innate immunity in protection against HIV-1 infection by studying NK cell function 37 Vietnamese intravascular drug users (IDUs), who appeared to remain uninfected despite many years high-risk exposure (exposed uninfected, EU), 10 IDUs underwent seroconversion and 28 unexposed blood donors. Main results were: lytic activities both NK-susceptible K562 line NK-resistant Daudi were significantly augmented EU compared with either controls or seroconverters...
ABSTRACT Human immunodeficiency virus (HIV) controllers are rare individuals who spontaneously control HIV type 1 replication for 10 years or more in the absence of antiretroviral treatment. In present study, ( n = 11) maintained potent HIV-specific CD4 responses spite very low antigenic loads. Their + central memory T (T CM ) cells were characterized by near-normal numbers and preserved interleukin-2 (IL-2) secretion response to antigens uniformly high expression survival receptor IL-7 α...
In this article, we studied the effect of acetyl-11-keto-beta-boswellic acid (AKbetaBA), a natural inhibitor proinflammatory transcription factor NF-kappaB on development atherosclerotic lesions in apolipoprotein E-deficient (apoE-/-) mice.Atherosclerotic were induced by weekly LPS injection apoE-/- mice. alone increased lesion size approximately 100%, and treatment with AKbetaBA significantly reduced it 50%. Moreover, activity was also plaques LPS-injected mice treated AKbetaBA. As...
Impairment of the intestinal barrier and subsequent microbial translocation (MT) may be involved in chronic immune activation, which plays a central role HIV pathogenesis. Th17 cells are critical to prevent MT. The aim study was investigate, patients with primary infection (PHI), early relationship between Th17/Treg ratio, monocyte activation MT their impact on T-cell set point, is known predict disease progression. 27 PHI were included prospective longitudinal followed-up for 6 months. At...
<h3>Objective</h3> The antiviral efficacy of nucleos(t)ide analogues whose main limitation is relapse after discontinuation requires long-term therapy. To overcome the risk and virological breakthrough during therapy, we performed a phase I/II, open, prospective, multicentre trial using HBV envelope-expressing DNA vaccine. <h3>Design</h3> 70 patients treated effectively with for median 3 years (HBV <12 IU/mL at least 12 months) were randomised into two groups: one received five...
Despite the availability of effective hepatitis B vaccines for many years, over 370 million people remain persistently infected with virus (HBV). Viral persistence is thought to be related poor HBV-specific T-cell responses. A phase I clinical trial was performed in chronic HBV carriers investigate whether DNA vaccination could restore responsiveness. Ten patients active nonresponder approved treatments infection were given 4 intramuscular injections 1 mg a vaccine encoding envelope...
Atherosclerosis has many features of a chronic inflammatory disease. To evaluate the role lipopolysaccharide (LPS), mimicking systemic infection, we administered endotoxin to apolipoprotein E (apoE)‐deficient mice. LPS injections increase atherosclerotic lesion size and titer plasma autoantibodies directed against oxidized low‐density lipoprotein. We found that Th1 Th2 T cells help activation B in autoimmune response. The number interleukin‐4 producing natural killer is highly increased...
Abstract Background Environmentally driven immune activation was suggested to contribute high rates of HIV-1 infection in Africa. We report here a study markers and susceptibility vitro forty-five highly exposed uninfected partners (EUs) infected individuals Central African Republic, comparison with forty-four low-risk blood donors (UCs). Results Analysis T lymphocyte subsets whole showed that the absolute values percentage HLA-DR + CD4 cells CCR5 were lower EUs than UCs (p = 0.0001)....
Expression of human apolipoprotein (h-apo) A-IV in apoE-deficient (apoE(0)) mice (h-apoA-IV/E(0)) reduces susceptibility to atherosclerosis. Chronic infection mimicked by exposure lipopolysaccharide (LPS) increases the size atherosclerosis lesions apoE(0) mice. Thus, we used h-apoA-IV/E(0) determine whether h-apoA-IV plays a protective role after LPS administration.We injected apoE(0), h-apoA-IV/E(0), and C57Bl/6 (wild-type) intraperitoneally with either or phosphate-buffered saline (PBS)...
Objective: Persistent immune activation plays a central role in the pathogenesis of HIV disease. Besides natural regulatory T cells (nTregs), 'double negative' shown to exhibit properties could be involved control harmful activation. The aim this study was analyze, patients with primary infection (PHI), relationship between CD4+CD25+CD127lowFoxP3+ nTregs or CD3+CD4−CD8− double negative and systemic Design: A prospective longitudinal early PHI. Methods: Twenty-five were included....
A substudy of a phase I/II, prospective, multicenter clinical trial was carried out to investigate the potential benefit therapeutic vaccination on hepatitis B e antigen-negative patients with chronic (CHB), treated efficiently analogues. Patients were randomized in 2 arms, one receiving virus (HBV) envelope DNA vaccine, and without vaccination. At baseline, HBV-specific interferon (IFN)-γ–producing T cells detected both groups after vitro expansion peripheral blood mononuclear cells....
Abstract Background The reportedly broad expression of CD85j across different immune cell types suggests an importance for this molecule in the human system. Previous reports have shown that receptor interacts with several HLA class-I molecules, as well some viral proteins. We demonstrated subset + Natural Killer (NK) cells efficiently controls immunodeficiency virus type 1 (HIV-1) replication monocyte-derived dendritic (MDDC) vitro and led us to hypothesize NK cell-mediated anti-HIV...
Serum levels of the interleukins (IL-1α, IL-2), tumor necrosis factor-alpha (TNF-α), and soluble receptor IL-2 (sIL-2R) were studied by enzyme-linked immunosorbent assay (ELISA) in 12 normal healthy controls 52 HIV-1 seropositive patients. Results indicated that: (1) sIL-2R significantly increased most This increase appeared to be correlated with low CD4 cell counts presence detectable p25 antigen. Furthermore, initially high progression disease. (2) found about 43% asymptomatic carriers...
Summary In response to inflammatory stimuli, monocytes/macrophages secrete greater quantities of the proinflammatory cytokines tumour necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β) and IL‐6. The process innate immune are related activation several transcription factors, such as nuclear factor κB (NF‐κB) activator protein 1 (AP‐1). proteasome is a multimeric protease complex, which plays vital role in cellular functions, including regulation factors like NF‐κB. this study, we used human...
Abstract Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a analogue histamine reduces production mouse model influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as used pDC. Our study establishes functional link between the innate immune system identifies CXCR4 potential ‘on-off’ switch activity with...
Conventional regulatory T cells (Tregs) can suppress human immunodeficiency virus type 1 (HIV-1)-specific immune responses but cannot control activation in primary HIV infection. Here, we characterized Treg subsets, using recently defined phenotypic delineation, and analyzed the relative contribution of cell subsets to production immunosuppressive cytokines infection.In a longitudinal prospective study, ex vivo phenotyping fresh peripheral blood mononuclear from patients with infection was...
Tuberculosis (TB) and AIDS are the leading causes of infectious disease death worldwide. In some TB-HIV co-infected individuals treated for both diseases simultaneously, a pathological inflammatory reaction termed immune reconstitution syndrome (IRIS) may occur. The risk factors IRIS not fully defined. We investigated association HLA-B, HLA-C, KIR genotypes with TB, HIV-1 infection, onset.Patients were divided into four groups: Group 1- TB+/HIV+ (n = 88; 11 them IRIS), 2- HIV+ 24), 3- TB+...