To describe overall site-specific hospital-acquired infection (HAI) rates and to the microbiological antibiotic resistance profiles of infecting pathogens, together with their impact on multidrug-resistant (MDR) bacteria-associated mortality.We conducted a 5-year retrospective descriptive study HAI in patients intensive care unit (ICU) cancer center Mexico from January 2007 December 2011. The following information was collected: patient characteristics comorbidities, data related neoplasm...

The aim of this study was to evaluate the clinical characteristics and risk factors associated with mortality in cancer patients bloodstream infections (BSI), analyzing multidrug resistant bacteria (MDR).We conducted a prospective observational at referral center from August 2016 July 2017, which included all BSI.4220 were tested blood cultures; 496 included. Mean age 48 years. In 299 solid tumors, secondary BSI Central Line-Associated (CLABSI) most common (55.9% 31.8%, respectively). 197...

Objectives To describe patterns of transmissible infections, chronic illnesses, socio-demographic characteristics and risk behaviors in Mexico City prisons, including comparison to the general population, identify those currently needing healthcare inform policy. Materials Methods A cross-sectional study among 17,000 prisoners at 4 prisons (June December 2010). Participation was voluntary, confidential based on informed consent. Participants were tested for HIV, Hepatitis B & C, syphilis,...

Genome sequencing has been useful to gain an understanding of bacterial evolution. It used for studying the phylogeography and/or impact mutation and recombination on populations. However, it rarely study gene turnover at microevolutionary scales. Here, we sequenced Mexican strains human pathogen Acinetobacter baumannii sampled from same locale over a 3 year period obtain insights into dynamics content variability. We found that A. population was recently founded emerging due rapid clonal...

Objective To describe the clinical features, outcomes, and molecular epidemiology of an outbreak multidrug resistant (MDR) A. baumannii. Methods We performed a retrospective analysis all MDR baumannii isolates recovered during from 2011 to 2015 in tertiary care cancer hospital. Cases were classified as colonized or infected. determined sequence types following Bartual scheme plasmid profiles. Results There 106 strains isolated study period. Sixty-six (62.3%) considered infection 40 (37.7%)...

Over the last few decades, carbapenemase-producing Acinetobacter baumannii has become a major cause of nosocomial infections all over world. However, genome identity lineages this species in Latin America not been studied as much developed countries. Here, through population genomics approach considering whole genomes 148 isolates (almost 40 from Mexico and Honduras), we describe recent emergence lineage sequence type 758 (ST758), which belongs to international clone V spread out Canada,...

Abstract Background Herpes zoster (HZ) typically causes a painful, unilateral, vesicular rash that affects one dermatome. In immunocompromised, it can disseminate and cause postherpetic neuralgia. The incidence of HZ has increased in recent years, especially elderly immunocompromised people, cancer patients included. Mexico low vaccination rate with no policy for at high risk HZ. Methods Between 2021 2023, all identified our Tertiary Cancer Institute were Demographics, clinical...

Abstract Background The inclusion of highly cytotoxic drugs for the treatment acute leukemia (AL) in last decade has exposed patients to more extended periods severe neutropenia. study aims describe prevalence and risk factors blood-stream infection (BSI) due carbapenem-resistant enterobacteria (CRE) with AL receiving chemotherapy.Table 1.Independent FLAG-IDA chemotherapy regimen had an OR 28.8 (CI 2.9-286.68. p=0.004) CRE-BSI Methods was performed at a referral center adult cancer Mexico...

Abstract Background Necrotizing Soft Tissue Infections (NSTI) are severe clinical entities that occur in specific contexts. Although, neutropenia related to hematological malignancies (HM) has been described relation with NSTI, there is a paucity of published data describing its course and outcome this populationTable 1.Population characteristics outcomesAll values represented N(%) unless otherwise noted an asterisk. Variables marked asterisk ( * ), median(interquartile range). LRINEC score:...

Anal cancer incidence is increased in people with HIV (PWH), up to 60 times higher men who have sex men, and almost 15 among women HIV. Screening treating high-grade lesions (HSIL) proven reduce the of invasive anal cancer. In 2020, we started implementing a high-resolution anoscopy (HRA) clinic at INCan, tertiary care oncologic center, as part screening program for PWH from clinic. We describe barriers difficulties an HRA Clinic January 2020 April 2021, including physician training,...

Abstract Background Co-infection with hepatitis B virus (HBV) and human immunodeficiency (HIV) is not infrequent as both share same route of exposure. The risk developing chronic 6%, in general population but can reach 10–20% HBV/HIV co-infected patients. When compared to population, the response rate HBV vaccine HIV-infected patients diminished, so previous studies have tried improve this using variety schedules, doses co-administration immunomodulators. purpose study was evaluate two...

Introduction Patients with hematologic malignancies have greater risk-factors for primary bloodstream infections (BSI). Methods From 2004–2009, we analyzed bacteremia caused by extended-spectrum beta-lactamase Escherichia coli (ESBL-EC) (n = 100) and compared cephalosporin-susceptible E. in patients malignancies. Objective To assess the clinical features, risk factors, outcome of ESBL-EC BSI malignancies, to study molecular epidemiology isolates. Results The main diagnosis was acute leukemia...

To investigate the predictive factors for development of Kaposi sarcoma-related immune reconstitution inflammatory syndrome (KS-IRIS) and long-term prognosis in patients starting combined antiretroviral therapy (cART).We studied a retrospective-cohort consecutive antiretroviral-naïve with KS initiating cART from January 2005 to December 2011 followed through June 2013. KS-IRIS was defined as ≥2 following: abrupt increase number lesions, appearance or exacerbation lung-opacities lymphedema,...

Cancer patients have a higher risk of severe sepsis in comparison with non-cancer patients, an increased for hospital-acquired infections (HAI), particularly multidrug resistant bacteria (MDRB). The aim the study is to describe frequency and characteristics HAI MDRB critically ill cancer patients. We conducted 18-month prospective admitted ≥48 h ICU at referral center Mexico. Patients hematological malignancies (HM) were compared solid tumors. Demographic clinical data recorded. Mortality...

Introduction: Patients with severe neutropenia who develop septic shock (SS) have high mortality. This study aimed to evaluate the risk factors and mortality of SS in patients HM febrile neutropenia. Methodology: We included all hematological malignancies (HM) presented fever neutropenia, admitted an oncological tertiary care center Mexico City for one year. Results: Two hundred ninety-two episodes were documented; 68 (23.2%) developed SS. Documented clinical infection was different between...

Introduction High HHV-8 viral load (VL) in Kaposi Sarcoma (KS) has been associated with Severe Immune Reconstitution Inflammatory Syndrome (Severe-IRIS-KS), which can occur after initiating cART, and leads to high mortality, particularly patients pulmonary involvement. We investigate if valganciclovir (as an anti-HHV-8 agent) initiated before cART reduces the mortality Severe-IRIS-KS incidence of Severe-IRIS-KS. Methods Open-label parallel-group randomized clinical trial AIDS naïve...

To date, the HIV epidemic in Mexico has been concentrated mainly among men who have sex with men, butheterosexual transmission, particularly to women, is increasingly important. This study examine gender differences socio-demographic characteristics and risk behaviors of positive individuals City. We analyzed data from a cross-sectional survey 1,490 clinic patients (male:female ratio 8:1) inMexico City 2010. examined characteristics, behavior, history infection.From multivariate non-linear...

Acinetobacter baumannii is a Gram-negative bacteria and significant nosocomial pathogen in hospitals. Multidrug-resistant A. have emerged as cause of infections critically ill patients. This microorganism has the ability to produce biofilms on different surfaces, which could explain their persist clinical environments role device-related infections.We present case 33-year-old Hispanic man with local invasive retroperitoneal leiomyosarcoma right kidney exclusion along femoral venous...