Background Coronavirus disease 2019 (COVID-19) is a systemic that can rapidly progress into acute respiratory failure and death. Timely identification of these patients crucial for proper administration health-care resources. Objective To develop predictive score estimates the risk invasive mechanical ventilation (IMV) among with COVID-19. Study design Retrospective cohort study 401 COVID-19 diagnosed from March 12, to August 10, 2020. The development comprised 211 (52.62% total sample)...

Abstract Invasive pulmonary aspergillosis (IPA) is a severe infection caused by aspergillus sp. that usually develops in patients with immunosuppression. IPA has been recently described critically ill COVID-19 (termed as COVID-associated aspergillosis, or CAPA) are otherwise immunocompetent. In order to describe the characteristics of CAPA, we conducted retrospective cohort study tertiary care center Mexico City. We included all confirmed admitted intensive unit had serum bronchoalveolar...

Struma ovarii is a rare monodermal variant of ovarian teratoma that contains at least 50% thyroid tissue. Less than 8% struma cases present with clinical and biochemical evidence thyrotoxicosis due to ectopic production hormone only 5% undergo malignant transformation into papillary carcinoma. Only isolated hormonally active carcinoma developing within have been reported in the literature. We report case 36-year-old woman who presented signs symptoms hyperthyroidism as well left adnexal...

A 57-year-old man presented to the outpatient clinic with tremor, palpitations, weight loss and fatigue 1 week after receiving first dose of Oxford-AstraZeneca SARS-CoV-2 vaccine (ChAdOx1 nCoV-19). Laboratory studies showed a suppressed TSH elevated total free T4. Thyroid peroxidase thyroglobulin antibodies were but thyrotropin receptor autoantibodies indeterminate. scintigraphy technetium Tc-99m pertechnetate revealed increased diffuse, symmetric uptake. The patient was treated thiamazole...

Describe the demographic, clinical, and biochemical characteristics of overweight or obese people with severe COVID-19 pneumonia evaluate its association mechanical ventilation requirements in a Mexican cohort.Data were obtained from medical electronic records. Patients divided three groups according to World Health Organization (WHO) classification body mass index (BMI): lean, obese. Baseline clinical course compared among these 3 groups.The study included total 355 patients confirmed...

Severe insulin resistance can be caused by rare genetic defects in the receptor known as receptoropathies. These cause a wide spectrum of clinical manifestations ranging from mild syndromes to lethal disorders. Among those is HAIR-AN an extreme subtype polycystic ovary syndrome (PCOS). We present case 29-year-old woman with amenorrhea, severe resistance, hirsutism, and acanthosis nigricans who also developed endometrial cancer. She was found carry novel heterozygous nonsense mutation gene...

Immune checkpoint inhibitors (ICI) are a group of drugs that have been used in recent years for the treatment advanced malignancies such as melanoma, non-small cell lung cancer and other tumors, significantly increasing survival. However, use ICI has associated with an increased risk autoimmune diseases, endocrine organs, specifically thyroid, being highly susceptible to this phenomenon.To describe incidence clinical characteristics patients treated who develop thyroid disease.The medical...

Abstract Lymphoma infiltration to the pituitary is rare. It represents less than 0.5% of all reported metastases (PMs). Here we present a case series 3 patients with PMs from systemic lymphoma. Also, performed literature review cases reported. We identified additional 31 in which non-Hodgkin lymphoma (NHL) was most common (n = 28, 90%), large B-cell NHL frequent histological subtype 14, 45%). Central hypothyroidism 21, 67%) deficiency followed by adrenal insufficiency 19, 61%) and diabetes...

Acute remission of acromegaly after a cocaine-induced apoplexy GH-secreting pituitary tumorDalia Cuenca. Department Medicine, American British Cowdray Medical Center.Latife Salame-Khouri. Neurology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.Daniela Shveid-Gerson. Center.Marco Antonio Alegría-Loyola. Center.Corresponding author: Moises Mercado. Endocrine Research Unit, Hospital Especialidades, Centro Médico Siglo XXI, IMSS, Mexico City, mmercadoa@yahoo.com

Abstract Background: Triple negative breast cancer (TNBC) represents around 15% of all tumors. Therapeutic strategies in TNBC are mainly based on classical chemotherapeutic agents, with limited success the metastatic setting. Here we have explored action a novel mithramycin analog named EC-8042 TNBC. Methods: used panel cell lines representative triple tumors including BT549, HBL100, HCC-1037, HS578T, MDA-MB213, HCC-1187, HCC-3153 and HCC-70. Proliferation studies were measured by MTT...

Abstract Background: Androgen receptor (AR) plays a central role in some tumor types like prostate cancer. Its expression and function breast cancer is relatively unknown. Studies have linked tyrosine kinase (TK) receptors their intracellular signaling pathways with AR status. In the present work we study presence of human samples how TKs can control its expression. Methods: Tumor from patients were used to assess by western-blot. Membrane kinases evaluated using phosphoprotein arrays. Cell...

Extragonadal choriocarcinoma is rare and can be associated with hyperthyroidism when producing very high levels of human chorionic gonadotropin.A 62-year-old Hispanic female presented a 3-week history shortness breath, palpitations, extreme weakness, new-onset hot flashes, right flank pain. Her physical examination was remarkable for tachycardia, hepatomegaly, hyperreflexia, tremor; goiter absent. Laboratory studies revealed increased lactate dehydrogenase, alkaline phosphatase, suppressed...

Systemic arterial hypertension, characterized by persistently high blood pressure in the systemic arteries, is a common disease aging population 1,2 .Globally, there prevalence of 74.5% adults aged 60 years or older.While majority (90-95%) patients have essential up to 10% secondary hypertension 1,3 .The concomitant primary and increases older age 3 principal causes are renal vascular disease, obstructive sleep apnea, terminal failure, drug-induced aldosteronism 2,3 .Uncommon include...

Abstract Malignant lymphoma of the pituitary gland is extremely rare. The most common form CNS involvement in leptomeningeal metastases, but it can also affect spine or cerebral parenchyma. Pituitary usually presents as diabetes insipidus present hypopituitarism if there adenohypophyseal destruction and may bitemporal hemianopsia. (1)We a case series four patients with metastatic lymphomas to that presented tertiary center Mexico City. Our investigation identified 4 previous diagnosis (3 B...

Abstract Mexico has been one of the most affected countries by COVID-19, with case rate 1195.32 per 100,000 patients and highest mortality rates worldwide. Diabetes found a major risk factor for severe COVID-19. high prevalence diabetes, estimated around 10.3%. On top this, recent estimates suggest that 4.1% population diabetes but does not have proper diagnosis. We conducted retrospective study in hospitalized COVID-19 tertiary private hospital City from March 15th to July 10th, 2020....

ResumenIntroducción: Los inhibidores del punto de control inmunológico (IPCi) son utilizados en los últimos años el tratamiento neoplasias malignas avanzadas, con ellos se ha logrado un aumento significativo la supervivencia; sin embargo, su uso asociado a incremento riesgo enfermedades autoinmunes.Objetivo: Describir incidencia y las características clínicas pacientes tratados IPCi que desarrollaron tiroidopatía.Métodos: Se revisaron retrospectivamente expedientes todos recibieron tres...