A5041451365- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Cervical Cancer and HPV Research
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Kruppel-like factors research
- Reproductive tract infections research
- Genital Health and Disease
- Neuroendocrine Tumor Research Advances
- Gut microbiota and health
- Olfactory and Sensory Function Studies
- interferon and immune responses
- Mathematical Biology Tumor Growth
- Adrenal Hormones and Disorders
- Magnesium in Health and Disease
- Hedgehog Signaling Pathway Studies
- Ovarian cancer diagnosis and treatment
- Genomic variations and chromosomal abnormalities
- Advanced Chemical Sensor Technologies
- RNA Research and Splicing
Mexican Social Security Institute
2015-2025
Centro Medico Nacional Siglo XXI
2017-2025
Hospital de Especialidades
2018-2025
Orthopedic Specialty Hospital
2022
Instituto Politécnico Nacional
2020
Center for Research and Advanced Studies of the National Polytechnic Institute
2018
Centro de Investigación en Materiales Avanzados
2017
Universidad Autónoma de Ciudad Juárez
2011-2015
COVID-19 counts 46 million people infected and killed more than 1.2 million. Hypoxaemia is one of the main clinical manifestations, especially in severe cases. HIF1α a master transcription factor involved cellular response to oxygen levels. The immunopathogenesis this form poorly understood.We performed scRNAseq from leukocytes five critically ill patients characterized expression hypoxia-inducible factor1α its transcriptionally regulated genes. Also metanalysis publicly available RNAseq...
Pituitary adenomas (PA) are the second most common intracranial tumors. These neoplasms classified according to hormone they produce. The majority of PA occur sporadically, and their molecular pathogenesis is incompletely understood. present transcriptomic methylomic analysis revealed that segregate into three clusters transcription factor driving terminal differentiation. First cluster, driven by NR5A1, consists clinically non-functioning (CNFPA), comprising gonadotrophinomas null cell;...
Obesity, type 2 diabetes, arterial hypertension, decrease in immune response, cytokine storm, endothelial dysfunction, and arrhythmias, which are frequent COVID-19 patients, associated with hypomagnesemia. Given that cellular influx efflux of magnesium calcium involve the same transporters, we aimed to evaluate association serum magnesium-to-calcium ratio mortality from severe COVID-19. The clinical laboratory data 1064 aged 60.3 ± 15.7 years, hospitalized by March 2020 July 2021 were...
Familial partial lipodystrophy type 2 is a rare disease, particularly when it caused by nonclassical gene variants. A high index of suspicion essential for timely diagnosis. We present the case 32-year-old woman, referred to evaluation possible Cushing syndrome, which was clinically and biochemically ruled out. Yet, due finding rather abnormal fat distribution during physical examination, diagnosis cogitated. Whole-exome sequencing revealed missense variant exon 11 R582H encoding Laminin...
Cervical cancer (CC) is a public health concern related to the human papillomavirus (HPV) persistent infection. Minichromosome maintenance 2 (MCM2) has been postulated as surrogate marker for HPV Thymopoietin (TMPO) nuclear protein regulated by E2F such MCM2 or p16. TMPO can give rise six different isoforms. Herein, both mRNA and levels of isoforms were analyzed in cervical cells. expression was selected through silico several databases from healthy cervix lesions. RNA evaluated samples cell...
Cervical Cancer (CC) has become a public health concern of alarming proportions in many developing countries such as Mexico, particularly low income sectors and marginalized regions. As such, an early detection is key medical factor improving not only their population's quality life but also its expectancy. Interestingly, there been increase the number reports describing successful attempts at detecting cancer cells human tissues or fluids using trained (sniffer) dogs. The great odor...
Traditional microbiological methodology is valuable and essential for microbiota composition description microbe role assignations at different anatomical sites, including cervical vaginal tissues; that, combined with molecular biology strategies modern identification approaches, could give a better perspective of the microbiome under circumstances. This pilot work aimed to describe differences in non-cancer women cancer through culturomics approach combining culture techniques Vitek mass...
Human Papillomavirus (HPV) in cervical epithelium has been identified as the main etiological factor developing of Cervical Cancer (CC), which recently become a public health problem Mexico. This finding allowed for development vaccines that help prevent this infection. In present study, we aimed to determine prevalence and HPV type-distribution Mexican women with CC, high-grade squamous intraepithelial lesion (HSIL), low-grade (LSIL), Normal cytology (N) estimate impact vaccines.The PubMed...
The aetiological relationship between human papillomavirus (HPV) infection and cervical cancer (CC) is widely accepted. Our goal was to determine the prevalence of HPV types in Mexican women attending at Institute for Social Security from different areas Mexico.DNAs 2,956 samples were subjected genotyping: 1,020 with normal cytology, 931 low-grade squamous intraepithelial lesions (LGSIL), 481 high grade HGSIL 524 CC.Overall 67.1%. A total 40 found; HPV16 detected 39.4% HPV-positive followed...
Corticotroph cells give rise to aggressive and rare pituitary neoplasms comprising ACTH-producing adenomas resulting in Cushing disease (CD), clinically silent ACTH (SCA), Crooke cell (CCA) carcinomas (CA). The molecular pathogenesis of these tumors is still poorly understood. To better understand the genomic landscape all lesions corticotroph lineage, we sequenced whole exome three SCA, one CCA, four ACTH-secreting PA causing CD, corticotrophinoma occurring a CD patient who developed Nelson...
Cervical cancer (CC) as other types, presents molecular deregulations, such the alterations of transcription factors. Krüppel-like factors (KLF) are a family transcriptional regulators. They involved in diverse cellular processes, proliferation, apoptosis, and angiogenesis among others. Here, we analyzed expression all 17 KLF members at messenger RNA (mRNA) level, protein two most commonly altered KLF5 KLF6 cervical tissues. Fifty-nine tissues ranging from normal tissue to CC were evaluated...
Abstract Background Pituitary adenomas (PA) are the second most common intracranial tumors and classified according to hormone they produce, transcription factors express. The majority of PA occur sporadically, their molecular pathogenesis is incompletely understood. Methods Here we performed transcriptome proteome analysis derived from POU1F1 (GH-, TSH-, PRL-tumors, N = 16), NR5A1 (gonadotropes null cells adenomas, n 17) TBX19 (ACTH-tumors, 6) lineages as well silent ACTH-tumors (n 3)...
We thank Dr. Scarpati and Piazza for their interest comments [...].
Abstract Neutrophils infiltrate several types of cancer; however, whether their presence is associated with disease progression remains controversial. Here, we show that colon tumors overexpress neutrophil chemoattractants compared to healthy tissues, leading recruitment the invasive margin and central part tumors. Of note, tumor-associated neutrophils expressing tumor necrosis factor α, which usually represents an antitumoral phenotype, were predominantly located in margin. Tumor-associated...
Abstract Worldwide, breast cancer (BrCa) is currently the leading cause of deaths associated to malignant lesions in adult women. Given that some studies have mentioned peritumoral adipocytes may contribute carcinogenesis, present work sought quantitative evaluate morphometry these cells a group Three thousand six hundred sixty four adipocytes, came from biopsies females with different types carcinomas (ductal, lobular, and mixed) one normal tissues, were evaluated through an image analysis...
Obesity has been described as a risk factor for COVID-19 severity and mortality. Previous studies report linear association between BMI adverse outcomes, meanwhile in other critical illness, excessive fat tissue is related to improved survival. Whether different with the survival of patients severe deserves further analysis.
Abstract Cervical cancer (CC) is associated with alterations in immune system balance, which primarily due to a shift from Th1 Th2 and the unbalance of Th17/Treg cells. Using silico DNA copy number analysis, we have demonstrated that ~20% CC samples exhibit gain 8q22.3 19q13.31; regions genome encodes KLF10 PSG genes, respectively. Gene expression studies there were no mRNA expression, whilst PSG2 −5 genes up-regulated by 1.76 3.97-fold respectively compared normal tissue controls. siRNA...