A5038199729- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Ophthalmology and Eye Disorders
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Adrenal Hormones and Disorders
- TGF-β signaling in diseases
- Hormonal Regulation and Hypertension
- Spanish Literature and Culture Studies
- Neuroblastoma Research and Treatments
- Philosophical Thought and Analysis
- Bariatric Surgery and Outcomes
- Galician and Iberian cultural studies
- Social Sciences and Policies
- Political Dynamics in Latin America
- Classical Philosophy and Thought
- Myasthenia Gravis and Thymoma
- Thyroid Disorders and Treatments
- Diet and metabolism studies
- Neuroendocrine Tumor Research Advances
- Thyroid Cancer Diagnosis and Treatment
- Respiratory Support and Mechanisms
- History of Education in Spain
- Comparative Literary Analysis and Criticism
Centro Medico Nacional Siglo XXI
2015-2025
Mexican Social Security Institute
2015-2025
Hospital de Especialidades
2015-2025
Red de Investigación Cardiovascular
2023
Sociedad Española de Endocrinología y Nutrición
2023
Communauté urbaine de Lyon
2018
Hôpital de la Croix-Rousse
2011-2017
Hospices Civils de Lyon
2017
Université Claude Bernard Lyon 1
2017
Institute of Experimental Endocrinology of the Slovak Academy of Sciences
2009
Acromegaly is usually due to the excessive secretion of GH by a pituitary adenoma. It frequently accompanied comorbidities that compromise quality life and results in elevated mortality rates.To evaluate morbidity patients with acromegaly receiving multimodal care.Tertiary care center.Retrospective evaluation 442 (65.4% women; mean age, 43.5 ± 13.1 y) followed for median 6 years (interquartile range [IQR], 3-10).Twenty-two died during study period (4.9%), representing total standardized...
Currently, bariatric surgery is the most effective treatment for severe obesity and its metabolic complications; however, 15-35% of patients that undergo do not reach their goal weight loss. The aim this study was to determine proportion didn't an excess loss 50% or more during first 12 months factors associated failure.We obtained demographic, anthropometric biochemical information from 130 with who underwent in our institution between 2012 2017. We used self-reports physical activity,...
Pituitary adenomas (PA) are the second most common intracranial tumors. These neoplasms classified according to hormone they produce. The majority of PA occur sporadically, and their molecular pathogenesis is incompletely understood. present transcriptomic methylomic analysis revealed that segregate into three clusters transcription factor driving terminal differentiation. First cluster, driven by NR5A1, consists clinically non-functioning (CNFPA), comprising gonadotrophinomas null cell;...
Genetic tests are part of the routine clinical approach to syndromic and nonsyndromic phenotypes neuroendocrine neoplasms (NENs). Current data on phenotype-genotype associations in NENs, however, do not accurately represent all populations. To describe frequency, inventory, germline defects associated with multiple types NENs a Mexican cohort. Blood DNA from adults was analyzed 53-gene NGS panel developed ad hoc (n=90) or Sanger sequencing (n=2). Single nucleotide variants, indels structural...
Background: Cardiomyopathy is the leading cause of morbidity and mortality in patients with acromegaly. Pharmacological surgical treatment disease has been associated morphological functional benefits for heart, but other studies have shown that condition its effects may be irreversible. This study aims to uncover most frequent echocardiographic changes cardiomyopathy due Methods: An observational, descriptive, cross-sectional was performed. Patients were referred from Endocrinology...
Familial partial lipodystrophy type 2 is a rare disease, particularly when it caused by nonclassical gene variants. A high index of suspicion essential for timely diagnosis. We present the case 32-year-old woman, referred to evaluation possible Cushing syndrome, which was clinically and biochemically ruled out. Yet, due finding rather abnormal fat distribution during physical examination, diagnosis cogitated. Whole-exome sequencing revealed missense variant exon 11 R582H encoding Laminin...
Background: Estrogen plays a crucial role in adipose tissue homeostasis, influencing fat distribution, lipid metabolism, and insulin sensitivity. Through estrogen receptor (ER) activation, particularly ERα, estradiol (E2) regulates adipogenesis, inhibits adipocyte hypertrophy, promotes signaling. It enhances oxidation, reduces lipogenesis, suppresses pro-inflammatory cytokine production, thereby maintaining metabolic health. Primary ovarian insufficiency (POI), characterized by deficiency...
Lack of exon 3 the GH receptor (d3-GHR) has been associated with increased responsiveness to therapy. By analogy, we hypothesized that patients acromegaly bearing d3-GHR genotype may have a more morbid clinical and biochemical picture.Our objective was determine whether GHR genotype, by modifying tissue sensitivity GH, influences clinical/biochemical expression its outcome after treatment.The study conducted at specialized clinic tertiary care hospital.We prospective investigation...
Somatostatin analogs (SA) have been used for over 25 years in the treatment of acromegaly. A major disadvantage is need to continue therapy indefinitely.To evaluate feasibility discontinuing well-controlled patients with acromegaly treated chronically SA.Of 205 subjects on octreotide LAR, we selected those who met following criteria: two or more treatment, a stable dose and injection interval 20 mg every 8 weeks longer previous year, no history radiation, cabergoline 6 months, GH <1.5 ng/ml,...
Object. According to a recent consensus statement on the treatment of acromegaly, its biochemical cure is defined as normalization age- and sex-adjusted insulin-like growth factor (IGF)—I levels suppression hormone (GH) by glucose lower than 1 ng/ml. The present study was prompted clinical observation that many cases acromegaly can be considered cured according one criterion but not others at different moments in patient's postoperative course. Methods. Fifty-three patients with (30 women 23...
Summary Background The definition of biochemical cure in acromegaly involves both the normalization IGF‐1 and a glucose‐suppressed GH level < 1 ng/ml. These criteria were reached by several consensus meetings, although no evidence‐based recommendations as to optimal time perform evaluations made, nor was fact that patients may change biochemically upon long‐term follow‐up taken into consideration. Objectives To identify characterize changes acromegaly. Patients methods One hundred...
<i>Objective:</i> To analyze clinical-biochemical correlations in newly diagnosed acromegaly, focusing particular on patients with discrepant parameters. <i>Design:</i> Retrospective study. <i>Methods:</i> Data from 164 acromegaly seen between 1995 and 2003. Patients were reviewed for the presence of headaches, arthralgias, hypertension, menstrual abnormalities, impotence, glucose intolerance or diabetes. Biochemical evaluation consisted age-...
Abstract Context Acromegaly registries constitute a valuable source of therapeutic outcome information in real-life. Objective The objective this work is to analyze surgical and pharmacological outcomes the Mexican Registry (MAR). Design Methods Data were extracted from MAR informatic platform. Surgical remission was defined by postoperative postglucose (GH) less than 1 ng/mL an insulin-like growth factor (IGF-1) 1.2 × upper limit normal (ULN). Pharmacological basal GH IGF-1 ULN. Results A...
Abstract Context The term micromegaly has been used to describe a subset of patients who have elevated IGF-1 levels but apparently normal basal GH (bGH) concentrations and often glucose-suppressed &lt;1 ng/mL. Objective To evaluate the prevalence, clinical spectrum, therapeutic outcome acromegaly with bGH at diagnosis. Design Methods Retrospective analysis cohort diagnosed treated tertiary care center. Results A 528 was stratified according diagnosis: group 1, &lt;2 ng/mL, n = 16; 2,...
Abstract Background Pituitary adenomas (PA) are the second most common intracranial tumors and classified according to hormone they produce, transcription factors express. The majority of PA occur sporadically, their molecular pathogenesis is incompletely understood. Methods Here we performed transcriptome proteome analysis derived from POU1F1 (GH-, TSH-, PRL-tumors, N = 16), NR5A1 (gonadotropes null cells adenomas, n 17) TBX19 (ACTH-tumors, 6) lineages as well silent ACTH-tumors (n 3)...