A5075207585- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Neurofibromatosis and Schwannoma Cases
- Cerebrospinal fluid and hydrocephalus
- Intracranial Aneurysms: Treatment and Complications
- Spinal Dysraphism and Malformations
- Bone Tumor Diagnosis and Treatments
- Vascular Malformations Diagnosis and Treatment
- History of Medical Practice
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroendocrine Tumor Research Advances
- Congenital Diaphragmatic Hernia Studies
- Spinal Fractures and Fixation Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Diversity and Career in Medicine
- Cerebrovascular and Carotid Artery Diseases
- Lymphoma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Surgical Simulation and Training
- CNS Lymphoma Diagnosis and Treatment
Centro Medico Nacional Siglo XXI
2012-2024
Centro Médico ABC
2012-2024
Mexican Social Security Institute
2009-2024
Hospital de Especialidades
2011-2024
Instituto Nacional de Neurología y Neurocirugía
2019-2024
Menéndez Pelayo International University
2023
Instituto Nacional de Cancerología
2022
Hospital Angeles Pedregal
2007-2021
Universidad Nacional Autónoma de México
2019-2021
Casio (Japan)
2019
Acromegaly is usually due to the excessive secretion of GH by a pituitary adenoma. It frequently accompanied comorbidities that compromise quality life and results in elevated mortality rates.To evaluate morbidity patients with acromegaly receiving multimodal care.Tertiary care center.Retrospective evaluation 442 (65.4% women; mean age, 43.5 ± 13.1 y) followed for median 6 years (interquartile range [IQR], 3-10).Twenty-two died during study period (4.9%), representing total standardized...
Context:Nonfunctioning pituitary adenomas (NFPA) are the most common neoplasms. There is no clinical, biochemical, or histopathological marker that would accurately predict recurrence of NFPA.
Background . Nonfunctioning pituitary adenomas (NFPAs) are the most common benign lesions of gland. Objective To describe our experience with management NFPA. Study Design and Methods Retrospective evaluation NFPA patients managed between 2008 2013. We analyzed data regarding clinical presentation, imaging diagnosis, hormonal status, surgical, radiotherapeutic, pharmacological treatment, outcome. Results 485 (54% men, mean age<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Pituitary adenomas (PA) are the second most common intracranial tumors. These neoplasms classified according to hormone they produce. The majority of PA occur sporadically, and their molecular pathogenesis is incompletely understood. present transcriptomic methylomic analysis revealed that segregate into three clusters transcription factor driving terminal differentiation. First cluster, driven by NR5A1, consists clinically non-functioning (CNFPA), comprising gonadotrophinomas null cell;...
Object. According to a recent consensus statement on the treatment of acromegaly, its biochemical cure is defined as normalization age- and sex-adjusted insulin-like growth factor (IGF)—I levels suppression hormone (GH) by glucose lower than 1 ng/ml. The present study was prompted clinical observation that many cases acromegaly can be considered cured according one criterion but not others at different moments in patient's postoperative course. Methods. Fifty-three patients with (30 women 23...
Summary Background The definition of biochemical cure in acromegaly involves both the normalization IGF‐1 and a glucose‐suppressed GH level < 1 ng/ml. These criteria were reached by several consensus meetings, although no evidence‐based recommendations as to optimal time perform evaluations made, nor was fact that patients may change biochemically upon long‐term follow‐up taken into consideration. Objectives To identify characterize changes acromegaly. Patients methods One hundred...
Corticotroph cells give rise to aggressive and rare pituitary neoplasms comprising ACTH-producing adenomas resulting in Cushing disease (CD), clinically silent ACTH (SCA), Crooke cell (CCA) carcinomas (CA). The molecular pathogenesis of these tumors is still poorly understood. To better understand the genomic landscape all lesions corticotroph lineage, we sequenced whole exome three SCA, one CCA, four ACTH-secreting PA causing CD, corticotrophinoma occurring a CD patient who developed Nelson...
<i>Objective:</i> To analyze clinical-biochemical correlations in newly diagnosed acromegaly, focusing particular on patients with discrepant parameters. <i>Design:</i> Retrospective study. <i>Methods:</i> Data from 164 acromegaly seen between 1995 and 2003. Patients were reviewed for the presence of headaches, arthralgias, hypertension, menstrual abnormalities, impotence, glucose intolerance or diabetes. Biochemical evaluation consisted age-...
Abstract OBJECTIVE AND IMPORTANCE: Vertebrobasilar aneurysms have a risk of rupture ranging from 2.5 to 50% (especially those larger than 7 mm) and repeat bleeding rate between 30 70%. For this reason, patients with mm should be treated. Considering the high complexity surgical approaches in area, an increasing number reported cases are being treated endovascular therapy. The purpose article is determine effectiveness safety sole stenting bypass treatment three consecutive vertebrobasilar...
Abstract Background Ventricular puncture is a common procedure in neurosurgery and the first that resident must learn. Ongoing education critical to improving patient outcomes. However, training at expense of potential risk patients warrants new safer methods for residents. Methods An augmented reality (AR) simulator practice ventricular punctures was designed. It consists navigation system with virtual 3D projection anatomy over 3D‐printed model. Forty‐eight participants from staff...
Abstract Background Pituitary adenomas (PA) are the second most common intracranial tumors and classified according to hormone they produce, transcription factors express. The majority of PA occur sporadically, their molecular pathogenesis is incompletely understood. Methods Here we performed transcriptome proteome analysis derived from POU1F1 (GH-, TSH-, PRL-tumors, N = 16), NR5A1 (gonadotropes null cells adenomas, n 17) TBX19 (ACTH-tumors, 6) lineages as well silent ACTH-tumors (n 3)...
Clinically non-functioning pituitary adenomas (CNFPAs) are the second most frequent sellar tumor among studies on community-dwelling adults. They characterized by absence of hormonal hypersecretion syndrome, and patients present with compressive symptoms, such as a headache visual field defects. Immunohistochemically, CNFPAs gonadotrope differentiation, only few them being truly null cell adenomas. Although these tumors express receptors for one or more hypothalamic releasing hormones, to...