A5008223215- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Parathyroid Disorders and Treatments
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Thyroid Cancer Diagnosis and Treatment
- Diabetes and associated disorders
- Ophthalmology and Eye Disorders
- Long-Term Effects of COVID-19
- Adrenal Hormones and Disorders
- Thyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- COVID-19 Clinical Research Studies
- Pharmacological Effects and Toxicity Studies
- Vitamin D Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
- Meningioma and schwannoma management
- Thyroid and Parathyroid Surgery
- Pharmaceutical studies and practices
- Sexual Differentiation and Disorders
- Immunodeficiency and Autoimmune Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
Mexican Social Security Institute
2015-2025
Centro Medico Nacional Siglo XXI
2015-2025
Hospital de Especialidades
2014-2025
Universidad Cuauhtémoc
2022
Corporació Sanitària Parc Taulí
2018
Universidad Nacional Autónoma de México
2017
Endocrinology Research Center
2017
Centro Médico ABC
2014-2016
Universidad de Las Palmas de Gran Canaria
2016
Complejo Hospitalario Dr. Arnulfo Arias Madrid
2016
Acromegaly is usually due to the excessive secretion of GH by a pituitary adenoma. It frequently accompanied comorbidities that compromise quality life and results in elevated mortality rates.To evaluate morbidity patients with acromegaly receiving multimodal care.Tertiary care center.Retrospective evaluation 442 (65.4% women; mean age, 43.5 ± 13.1 y) followed for median 6 years (interquartile range [IQR], 3-10).Twenty-two died during study period (4.9%), representing total standardized...
Context:Nonfunctioning pituitary adenomas (NFPA) are the most common neoplasms. There is no clinical, biochemical, or histopathological marker that would accurately predict recurrence of NFPA.
Background . Nonfunctioning pituitary adenomas (NFPAs) are the most common benign lesions of gland. Objective To describe our experience with management NFPA. Study Design and Methods Retrospective evaluation NFPA patients managed between 2008 2013. We analyzed data regarding clinical presentation, imaging diagnosis, hormonal status, surgical, radiotherapeutic, pharmacological treatment, outcome. Results 485 (54% men, mean age<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract Context Diabetes and hypertension are frequent comorbidities of acromegaly. Objective To analyze the course diabetes at diagnosis after multimodal therapy in a large cohort patients with Design Setting Retrospective study tertiary care center. Patients Methods A total 522 acromegaly treated according to preestablished protocol. Main Outcome Measures Prevalence its relationship biochemical indices acromegalic control. Results The was stratified disease activity upon last visit...
Pituitary adenomas (PA) are the second most common intracranial tumors. These neoplasms classified according to hormone they produce. The majority of PA occur sporadically, and their molecular pathogenesis is incompletely understood. present transcriptomic methylomic analysis revealed that segregate into three clusters transcription factor driving terminal differentiation. First cluster, driven by NR5A1, consists clinically non-functioning (CNFPA), comprising gonadotrophinomas null cell;...
Genetic tests are part of the routine clinical approach to syndromic and nonsyndromic phenotypes neuroendocrine neoplasms (NENs). Current data on phenotype-genotype associations in NENs, however, do not accurately represent all populations. To describe frequency, inventory, germline defects associated with multiple types NENs a Mexican cohort. Blood DNA from adults was analyzed 53-gene NGS panel developed ad hoc (n=90) or Sanger sequencing (n=2). Single nucleotide variants, indels structural...
Lack of exon 3 the GH receptor (d3-GHR) has been associated with increased responsiveness to therapy. By analogy, we hypothesized that patients acromegaly bearing d3-GHR genotype may have a more morbid clinical and biochemical picture.Our objective was determine whether GHR genotype, by modifying tissue sensitivity GH, influences clinical/biochemical expression its outcome after treatment.The study conducted at specialized clinic tertiary care hospital.We prospective investigation...
Somatostatin analogs (SA) have been used for over 25 years in the treatment of acromegaly. A major disadvantage is need to continue therapy indefinitely.To evaluate feasibility discontinuing well-controlled patients with acromegaly treated chronically SA.Of 205 subjects on octreotide LAR, we selected those who met following criteria: two or more treatment, a stable dose and injection interval 20 mg every 8 weeks longer previous year, no history radiation, cabergoline 6 months, GH <1.5 ng/ml,...
Abstract Context Acromegaly registries constitute a valuable source of therapeutic outcome information in real-life. Objective The objective this work is to analyze surgical and pharmacological outcomes the Mexican Registry (MAR). Design Methods Data were extracted from MAR informatic platform. Surgical remission was defined by postoperative postglucose (GH) less than 1 ng/mL an insulin-like growth factor (IGF-1) 1.2 × upper limit normal (ULN). Pharmacological basal GH IGF-1 ULN. Results A...
Abstract Background The SARS-CoV-2 pandemic continues to be a priority health problem; According the World Health Organization data from October 13, 2020, 37,704,153 confirmed COVID-19 cases have been reported, including 1,079,029 deaths, since outbreak. identification of potential symptoms has reported useful tool for clinical decision-making in emergency departments avoid overload and improve quality care. aim this study was evaluate performances as diagnostic SARS -CoV-2 infection....
Objective . To compare the serum concentration of IL-6, IL-10, TNF, IL-8, resistin, and adiponectin in type 1 diabetic patients with without metabolic syndrome to determine cut-off point estimated glucose disposal rate that accurately differentiated these groups. Design We conducted a cross-sectional evaluation all our diabetes clinic from January 2012 2013. Patients were considered have when they fulfilled joint statement criteria evaluated for clinical, biochemical, immunological features....
Abstract Context The term micromegaly has been used to describe a subset of patients who have elevated IGF-1 levels but apparently normal basal GH (bGH) concentrations and often glucose-suppressed &lt;1 ng/mL. Objective To evaluate the prevalence, clinical spectrum, therapeutic outcome acromegaly with bGH at diagnosis. Design Methods Retrospective analysis cohort diagnosed treated tertiary care center. Results A 528 was stratified according diagnosis: group 1, &lt;2 ng/mL, n = 16; 2,...
Abstract Objectives At the end of 2019, SARS‐CoV‐2 was identified, one responsible for COVID‐19 disease. Between a 5.1% and 98% patients present some form alteration in their sense smell. The objective this study is to determine diagnostic yield smell dysfunction as screening tool COVID‐19. Methods Cross‐sectional, observational, pro‐elective performed tertiary care hospital from May 25th June 30th, 2020. One hundred thirty‐nine were included study. Demographic characteristics collected...
Abstract Background Pituitary adenomas (PA) are the second most common intracranial tumors and classified according to hormone they produce, transcription factors express. The majority of PA occur sporadically, their molecular pathogenesis is incompletely understood. Methods Here we performed transcriptome proteome analysis derived from POU1F1 (GH-, TSH-, PRL-tumors, N = 16), NR5A1 (gonadotropes null cells adenomas, n 17) TBX19 (ACTH-tumors, 6) lineages as well silent ACTH-tumors (n 3)...
A 19-year-old woman with a history of isosexual precocious puberty and bilateral oophorectomy at age 10 years because giant ovarian cysts, presents headaches mild symptoms signs hyperthyroidism. Hormonal evaluation revealed elevated FSH LH levels in the postmenopausal range free hyperthyroxinemia an inappropriately normal TSH. Pituitary MRI showed 2-cm macroadenoma suprasellar extension. She underwent successful surgical resection pituitary tumor, which proved to be composed two distinct...
Primary hyperparathyroidism (PHPT) and metabolic syndrome (MS) have been independently related to cardiovascular morbidities, however this association is still controversial. Mexican population has a high prevalence of syndrome, its frequency seems be even higher than expected in patients with PHPT. We retrospectively reviewed the charts that underwent parathyroidectomy for PHPT referral center used criteria from National Cholesterol Educational Program (NCEP)/Adult Treatment Panel III (ATP...
To analyze, in a cohort of acromegalic patients, the results efficiency and safety radiosurgery (CyberKnife), as well prognostic factors associated with disease remission.Observational, retrospective, longitudinal, analytical study that included patients persistent biochemical activity after initial medical-surgical treatment, who received treatment CyberKnife radiosurgery. GH IGF-1 levels at baseline one year end follow-up were evaluated.57 included, median four years (IQR, 2-7.2 years)....
Fatigue is a common symptom in hypothyroidism; however, the effect of levothyroxine on fatigue has been little studied. The aim this study was to evaluate Latino patients with primary hypothyroidism, as well association TSH and free T4 (FT4) severity persistence fatigue.A prospective performed 92 hypothyroidism. scale (FSS) scores clinical biochemical characteristics before at 6 months were evaluated.After levothyroxine, reduction FSS (53 (47-57) vs. 36 (16-38); p = 0.001) frequency (45.7%...