A5022913108- Diabetes Management and Research
- Genetic Associations and Epidemiology
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Adipose Tissue and Metabolism
- Health and Lifestyle Studies
- Birth, Development, and Health
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Regulation of Appetite and Obesity
- Gestational Diabetes Research and Management
- COVID-19 and Mental Health
- Diabetes Management and Education
- SARS-CoV-2 and COVID-19 Research
- Nutritional Studies and Diet
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Hemodynamic Monitoring and Therapy
- Sodium Intake and Health
- Cardiac, Anesthesia and Surgical Outcomes
- Health and Medical Education
Mexican Social Security Institute
2015-2025
Centro Medico Nacional Siglo XXI
2013-2024
Hospital de Especialidades
2015-2024
Universidad Autónoma del Estado de México
2004
Hospital Médica Sur
2000
Type 2 diabetes (T2D) is influenced by diverse environmental and genetic risk factors. Metabolic syndrome (MS) increases the of cardiovascular disease diabetes. We analysed 14 cases polymorphisms located in 10 candidate loci, a sample patients with T2D controls from Mexico City.We association within genes (TCF7L2, ENPP1, ADRB3, KCNJ11, LEPR, PPARgamma, FTO, CDKAL1, SIRT1 HHEX) MS. The analysis included 519 subjects defined according to ADA criteria, 389 MS AHA/NHLBI criteria 547 controls....
The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos. Because a pivotal role for ABCA1 pancreatic beta-cell function was recently observed mouse model, we assessed association of this type 2 diabetes population.The initial group included 446 unrelated Mexican individuals: 244 aged 20-69 years (121 onset </=45 years), 202 nondiabetic control subjects >50 years. An independent study...
COVID-19 counts 46 million people infected and killed more than 1.2 million. Hypoxaemia is one of the main clinical manifestations, especially in severe cases. HIF1α a master transcription factor involved cellular response to oxygen levels. The immunopathogenesis this form poorly understood.We performed scRNAseq from leukocytes five critically ill patients characterized expression hypoxia-inducible factor1α its transcriptionally regulated genes. Also metanalysis publicly available RNAseq...
HOMA, homeostasis model assessment; HOMA-IR, HOMA of insulin resistance
ABSTRACT Background Although several lines of evidence suggest that hypomagnesaemia is a risk factor for developing type 2 diabetes, there are no studies regarding the association between and impaired fasting glucose (IFG) or tolerance (IGT). Our objective was to examine serum magnesium levels IFG, IGT diabetes. Materials methods A total 1122 individuals (20–65 years age) were enrolled 1996 1997, 817 re‐examined about 10 later. New‐onset IFG (5·6–7·0 mmol L −1 glucose), (7·8–11·1 2‐h...
This study is aimed to assess the link between oxidative stress markers and incident hyperglycemia in women with gestational diabetes mellitus (GDM) during an educational intervention. The used a prospective cohort. Pregnant GDM who were 18-40 years old (n = 201) participated 18-month postpartum intervention emphasizing healthy practices (nutrition, breastfeeding, physical activity, psychosocial support). tested oral glucose tolerance test (OGTT) after third month postpartum, classified as...
To compare the carotid artery intima-media thickness in Hispanic pediatric type 1 diabetic patients against that healthy control subjects matched for age, sex, height, and BMI.The evaluation consisted of anthropometric measurements, biochemical parameters, a Doppler real-time ultrasound, which (cIMT), peak systolic velocity, end diastolic velocity were measured using standardized procedures.A total 52 47 included. No significant differences existed characteristics between case (mean age 11.8...
The aim of this study is to determine whether insulin resistance associated with elevation transaminases levels and aspartate aminotransferase (AST)/alanine (ALT) ratio in normal-weight healthy young adults.Apparently nonpregnant women men, aged 18-23 years, were enrolled a cross-sectional study. According the homeostasis model assessment resistance, participants allocated into groups patients (>2.5) without (≤2.5) resistance. Normal weight was defined by BMI at least 18.5 less than 25.0...
Polymorphisms within the transcription factor 7‐like 2 gene ( TCF7L2 ) have been associated with type diabetes (T2D) in several recent studies. We characterized three of these polymorphisms (rs12255372, rs7903146 and microsatellite DG10S478) an admixed sample 286 patients T2D 275 controls from Mexico City. also analyzed samples representative relevant parental populations: Native Americans state Guerrero (Mexico), Spanish Valencia Nigerians (Bini Edo region). In order to minimize potential...
The organic cation transporters OCT1 and OCT2 the multidrug toxin extrusion transporter MATE1, encoded by SLC22A1, SLC22A2, SLC47A1 genes, respectively, are responsible for absorption of metformin in enterocytes, hepatocytes, kidney cells. aim this study was to evaluate whether genetic variations genes could be associated with an altered response patients type 2 diabetes mellitus. A cohort conducted 308 individuals a diagnosis mellitus less than 3 years who had monotherapy. Three...
The aim of this study is to describe the percentile distribution waist circumference in Mexican pre-pubertal children living an urban, middle-income area.Children, aged 6-10, from a primary school, located area Mexico City were included (n=833). Anthropometric measurements made case all by using standardized procedures.The prevalence obesity and overweight was greater among boys (p<0.001). Of them, 30 obese (7.2%) 47 (11.4%). Girls had 2.8% 8.8%. Boys than girls This observation independent...
Summary Type 2 diabetes (T2D) is characterized by a chronic low‐grade inflammatory state. SNP in Toll‐like receptor (TLR) genes has been associated with impaired response. We genotyped the TLR4/D299G, TLR4/T399I and TLR2/R753Q polymorphisms. Low frequency was found no association T2D, nevertheless TLR2 lower levels HDL‐cholesterol values.
Background: The prevalence of obesity has increased in patients with type 1 diabetes (T1D) and latent autoimmune the adult (LADA), limiting use clinical features such as body mass index for its differentiation 2 (T2D). Additionally, some maturity-onset young (MODY) or LADA are misdiagnosed having T2D. evaluation autoantibodies genetic testing not fully available. We aimed to evaluate utility a widely available less expensive diagnostic tool C-peptide differentiate between T1D, T2D, MODY,...
The prevention of type 2 diabetes is a challenge for health institutions. Periodic blood glucose screening in subjects at risk developing may be necessary to implement preventive measures patients prior the manifestation disease and efficiently diagnose diabetes. Not only medical aspects, but also psychological social factors, such as perception (the individuals' judgment likelihood experiencing an adverse event) influence healthy or behaviors. It still unknown if can have effect on...