A5056204468- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Eosinophilic Disorders and Syndromes
- Natural product bioactivities and synthesis
- Immune Cell Function and Interaction
- Blood Coagulation and Thrombosis Mechanisms
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- Angiogenesis and VEGF in Cancer
- Venous Thromboembolism Diagnosis and Management
- Phagocytosis and Immune Regulation
- Childhood Cancer Survivors' Quality of Life
- Pituitary Gland Disorders and Treatments
- Apelin-related biomedical research
- Long-Term Effects of COVID-19
- Multiple Myeloma Research and Treatments
- Bioactive Compounds and Antitumor Agents
- Mesenchymal stem cell research
- Cancer therapeutics and mechanisms
- Plant-derived Lignans Synthesis and Bioactivity
- NF-κB Signaling Pathways
- Tannin, Tannase and Anticancer Activities
Centro Medico Nacional Siglo XXI
2005-2025
Mexican Social Security Institute
2014-2024
Universidad Nacional Autónoma de México
2001
COVID-19 counts 46 million people infected and killed more than 1.2 million. Hypoxaemia is one of the main clinical manifestations, especially in severe cases. HIF1α a master transcription factor involved cellular response to oxygen levels. The immunopathogenesis this form poorly understood.We performed scRNAseq from leukocytes five critically ill patients characterized expression hypoxia-inducible factor1α its transcriptionally regulated genes. Also metanalysis publicly available RNAseq...
Since the second half of 20th century, our knowledge about biology cancer has made extraordinary progress. Today, we understand at genomic and epigenomic levels, have identified cell that starts neoplastic transformation characterized mechanisms for invasion other tissues. This allowed novel drugs to be designed act on specific molecular targets, immune system trained manipulated increase its efficiency, ever more effective therapeutic strategies developed. Nevertheless, are still far from...
Introduction: Leukemia is among the most common types of cancer. Currently, main anti-leukemia treatments have significant drawbacks, which has led to search for new and better drugs, especially those developed from natural products. Objective: The aim this work was perform simple modifications a lupane-type pentacyclic triterpene isolated Phoradendron wattii , in order generate semi-synthetic analogues their possible effect against panel leukemia cell lines. Methods: Simple structural on 3...
Abstract Tyrosine kinase inhibitors ( TKI ) have become a first‐line treatment for chronic myeloid leuakemia CML ). s efficiently target bulk cells; however, they are unable to eliminate the leukaemic stem cell LSC population that causes resistance and relapse in patients. In this study, we assessed effects of parthenolide PTL dimethyl amino DMAPT ), two potent acute leukaemia AML on primitive CD 34 + lin − cells. We found both agents induced death , while having little effect equivalent...
Chronic Myeloid Leukemia (CML) is sustained by a small population of cells with stem cell characteristics known as Leukemic Stem Cells that are positive to BCR-ABL fusion protein, involved several abnormalities in proliferation, expansion, apoptosis and cycle regulation. Current treatment options for CML involve the use Tirosine Kinase Inhibitor (Imatinib, Nilotinib Dasatinib), efficiently reduce proliferation proliferative but do not kill non proliferating primitive remain contributes...
Abstract In this study, we determined the gene expression profiles of bone marrow‐derived cell fractions, obtained from normal subjects and Chronic Myeloid Leukemia ( CML ) patients, that were highly enriched for hematopoietic stem HSC s) progenitor HPC cells. Our results indicate s closer to progenitors, whereas showed most different profile all. We found marrow each other than those marrow. The major biologic processes dysregulated in cells included DNA repair, cycle, chromosome...
Background Venous thromboembolic disease (VTD) is a public health problem. We recently reported that endothelial colony-forming cells (ECFCs) derived from (EC) (ECFC-ECs) patients with VTD have dysfunctional state. For this study, we proposed status of these generates reduction its proliferative ability, which also associated senescence and reactive oxygen species (ROS). Methods results Human mononuclear (MNCs) were obtained peripheral blood 40 healthy human volunteers (controls) 50 matched...
Mexico is among the countries with highest estimated excess mortality rates due to COVID–19 pandemic, more than half of reported deaths occurring in adults younger 65 years old. Although this behavior presumably influenced by young demographics and high prevalence metabolic diseases, underlying mechanisms have not been determined. The age–stratified case fatality rate (CFR) was a prospective cohort 245 hospitalized cases, followed through time, for period October 2020–September 2021....
Acute lymphoblastic leukemia (ALL) is a hematopoietic disorder that mainly affects the child population, and it characterized by presence of lymphoid progenitor or precursor cells with different genetic alterations. The origin this disease controversial, since some authors assumed leukemic transformation occurs in progenitor, there also evidence suggests existence initiating (LIC). PTL, DMAPT, PU-H71 are agents have been shown to eliminate bulk stem from myeloid leukemias, but effect has not...
Abstract Identification of organic compounds from plants is clinical significance because the effect that they might have in patients with haematopoietic disorders. We studied plant extract Justicia spicigera (Acanthaceae) different cells: human leukaemic cell lines, umbilical cord blood cells, and mouse bone marrow cells. By examining colony formation performing MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide) assay it was shown contains cytotoxic factors for cells has no...
The goal of the present study was to investigate specific way in which recombinant stimulatory cytokines modulate cell cycle dynamics primitive hematopoietic cells vitro. A human cord blood-derived population, enriched for CD34+ Lin− cells, obtained by negative selection and cultured liquid cultures, absence or presence cytokines. proportion each phase cycle, as well expression cyclin D3, cyclin-dependent kinase-4 (cdk4), p16, p21 p27, determined at different time points. At onset culture,...