A5038951415- Virology and Viral Diseases
- Virus-based gene therapy research
- Hepatitis C virus research
- Glycosylation and Glycoproteins Research
- Mosquito-borne diseases and control
- Animal Virus Infections Studies
- Cervical Cancer and HPV Research
- Hepatitis B Virus Studies
- Influenza Virus Research Studies
- Galectins and Cancer Biology
- Animal Disease Management and Epidemiology
- Viral Infections and Vectors
- Respiratory viral infections research
- Malaria Research and Control
- Liver Disease Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Microbial infections and disease research
- Viral Infections and Immunology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer, Hypoxia, and Metabolism
- Proteoglycans and glycosaminoglycans research
- vaccines and immunoinformatics approaches
- Cancer Research and Treatments
- Macrophage Migration Inhibitory Factor
- COVID-19 Clinical Research Studies
Benemérita Universidad Autónoma de Puebla
2022-2025
Mexican Social Security Institute
2014-2023
Universidad de Puebla
2023
Hospital General De Zona
2004-2016
Universidad Nacional Autónoma de México
1993-1997
Due to their crucial role in cell metabolism and homeostasis, alterations mitochondrial biology function have been related the progression of diverse diseases including cancer. One consequences associated dysfunction is production reactive oxygen species (ROS). ROS are known a controversial during cancer initiation although several studies tried manipulate intracellular levels using antioxidants or pro-oxidation conditions, it not yet clear how target oxidation for therapy. In this study, we...
Background: There is a lack of specific antiviral therapy against dengue virus (DENV) in current use. Therefore, great proportion cases progress to severe clinical forms due complex interplay between and host immune response. It has been hypothesized that heterotypic non-neutralizing antibodies enhance DENV infection phagocytic cells, this induces an inflammatory response involved the pathogenesis dengue. Purpose: To identify immunomodulatory effects polyphenols on infection. Methods: Human...
In viral disease, infection is controlled at the cellular level by type I interferon (IFN-I), but dengue virus (DENV) has ability to inhibit this response. Type III interferon, also known as lambda IFN (IFN-III or IFN-λ), a complementary pathway antiviral response IFN-I. This work analyzed IFN-λ (IFN-III) mediated against DENV serotype 2 (DENV-2) infection.Dengue fever patients were sampled determine their levels ELISA. To study during we selected epithelial cell line C33-A, and demonstrated...
Urtica dioica, Taraxacum officinale, Calea integrifolia and Caesalpinia pulcherrima are widely used all over the world for treatment of different illnesses. In Mexico, these plants traditionally to alleviate or counteract rheumatism inflammatory muscle diseases. present study we evaluated activity aqueous methanolic extracts four plants, on replication dengue virus serotype 2 (DENV2).Extraction process was carried out in a Soxtherm® system at 60, 85 120 °C; chemical fractionation silica gel...
The binding of programmed cell death receptor-ligand 1 (PD-L1) to protein (PD-1) inhibits T-cell activation, playing a negative role in the anticancer immune response. soluble forms these proteins, found blood circulation, have recently received increasing attention and their function cancer response remains unclear. present study evaluated serum levels (s)PD-1 sPD-L1 patients with cervical healthy controls, associations clinicopathological characteristics clinical outcomes. concentrations...
T‑cell immunoglobulin and mucin domain‑containing protein‑3 (Tim‑3) is an immune checkpoint molecule that expressed generally on the cell membrane of cancer cells implicated as a negative regulator anti‑tumour responses; this occurs through interaction Tim‑3 with galectin‑9. Although function well known, role soluble (sTim‑3) has been poorly explored. The aim present study was to compare serum levels sTim‑3 in cervical group patients vs. control group, determine association between...
Cytokines play important roles in the physiopathology of dengue infection; therefore, suppressors cytokine signaling (socs) that control type and timing functions could be involved origin immune alterations dengue.To explore association socs levels with disease severity patients.Blood samples 48 patients confirmed infection were analyzed. Amounts interleukins IL-2, IL-4, IL-6, IL-10, interferon- (IFN-) γ, tumor necrosis factor- (TNF-) α quantified by flow cytometry, relative expression socs1...
The aetiological relationship between human papillomavirus (HPV) infection and cervical cancer (CC) is widely accepted. Our goal was to determine the prevalence of HPV types in Mexican women attending at Institute for Social Security from different areas Mexico.DNAs 2,956 samples were subjected genotyping: 1,020 with normal cytology, 931 low-grade squamous intraepithelial lesions (LGSIL), 481 high grade HGSIL 524 CC.Overall 67.1%. A total 40 found; HPV16 detected 39.4% HPV-positive followed...
Breast cancer is the main cause of cancer-related death in women world. Because autophagy a known survival pathway for cells, its inhibition currently being explored clinical trials treating several types malignancies. In breast cancer, has been shown to be necessary cells from triple negative subtype (TNBC), which worst prognosis among cancers and limited therapeutic options. Autophagy also involved regulation protein secretion and, importance this work, promote proinflammatory cytokines...
The membrane protein M of the Porcine Epidemic Diarrhea Virus (PEDV) is most abundant component viral envelope. plays a central role in morphogenesis and assembly virus through interactions M-M, M-Spike (S) M-nucleocapsid (N) type. known to induce protective antibodies pigs participate antagonistic response cellular antiviral system coordinated by type I III interferon pathways. 3D structure PEDV still unknown. present work exposes predicted model generated using Robetta protocol. organized...
Altered sialylation has been observed during oncogenic transformation. Sialylated oligosaccharides of glycoproteins and glycolipids have implicated in tumor progression metastases. In the cervical cancer high levels sialic acid reported patients serum, an increased total concentration for neoplasia cancer. This study investigates changes expression distribution α2,3-linked α2,6- linked low squamous intraepithelial lesions normal tissue.Lectin histochemistry was used to examine different...
Our objective was to evaluate whether vitamin D deficiency is associated with cervical human papilloma virus (HPV) infection in women SLE. This a cross-sectional study of 67 A structured questionnaire administered ascertain the possible risk factors HPV infection. gynaecological evaluation and cytology screening were made. detection genotyping made by PCR linear array assay. Serum 25 hydroxyvitamin levels quantified chemiluminescence immunoassay. Mean age disease duration 44.8 ± 10.6 42.5...
To determine the prevalence of human papillomavirus (HPV) genotypes 6, 11, 16, 18, and 31 in Mexican women living rural areas Puebla, Mexico to evaluate risk factors associated with cervical neoplasm this population.A cross-sectional study was conducted 326 at General Hospital Metepec, Puebla. Cervical samples were obtained using a cytobrush tested for HPV by PCR assays type-specific primers. A questionnaire completed regarding gynecological, obstetric, sexual behavior patients.The overall...
Abstract Background Worldwide, 130 million persons are estimated to be infected with HCV. Puebla is the Mexican state highest mortality due hepatic cirrhosis. Therefore, it imperative obtain epidemiological data on HCV infection in asymptomatic people of this region. The objective present study was analyze prevalence antibodies and genotypes hepatitis C virus (HCV) blood donors from Puebla, Mexico. Results overall 0.84% (515/61553). Distribution by region was: North, 0.86% (54/6270);...
Turnera diffusa Willd, commonly known as Damiana, is employed in traditional medicine a stimulant, aphrodisiac, and diuretic. Its leaves stems are used for flavoring infusion. Damiana considered to be safe medicinal use by the FDA. Pharmacological studies have established hypoglycemic, antiaromatase, prosexual, estrogenic, antibacterial, antioxidant activity of T. diffusa. The aim present study was evaluate possible cytotoxic effect extracts organic fractions this plant on five tumor cell...