A5071401111- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- Cytokine Signaling Pathways and Interactions
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Reproductive tract infections research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Gastric Cancer Management and Outcomes
- Immunotherapy and Immune Responses
- Olfactory and Sensory Function Studies
- Gut microbiota and health
- Genetic factors in colorectal cancer
- Advanced Chemical Sensor Technologies
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Retinoids in leukemia and cellular processes
- Nanotechnology research and applications
- Immune cells in cancer
Autonomous University of Tlaxcala
2018-2025
Universidad Nacional Autónoma de México
2018-2025
New York University
2021-2022
Instituto Politécnico Nacional
2008-2019
Center for Research and Advanced Studies of the National Polytechnic Institute
2017-2019
Mexican Social Security Institute
2011-2018
Polytechnic University of Puerto Rico
2018
Hospital Privado
2012
University of the Andes
2011
Centro Medico Nacional Siglo XXI
2011
Abstract Cancer‐associated aberrant glycosylation can be detected by the macrophage galactose‐type C‐type lectin (MGL) receptor; however, whether this interaction enhances or deadens cancer development along with associated immune response has not been well established. To determine role of mouse MGL1 in colitis‐associated colon (CAC), azoxymethane (AOM)/dextran sodium sulfate (DSS)‐induced tumor was compared between Mgl1 knockout ( −/− ) mice and their wild‐type (WT) littermates. At 75 days...
Cervical Cancer (CC) has become a public health concern of alarming proportions in many developing countries such as Mexico, particularly low income sectors and marginalized regions. As such, an early detection is key medical factor improving not only their population's quality life but also its expectancy. Interestingly, there been increase the number reports describing successful attempts at detecting cancer cells human tissues or fluids using trained (sniffer) dogs. The great odor...
The mechanisms behind the induction of malignancy and chemoresistance in breast cancer cells are still not completely understood. Inflammation is associated with different types highlighted as an important factor for chemoresistance. In previous work, we demonstrated that inflammatory cytokine interleukin 1β (IL-1β)-induced upregulation genes was cells. Here, evaluated participation expression profile TP63 resistance to cisplatin. By loss-of-function assays, identified IL-1β particularly...
Inflammation is currently considered a hallmark of cancer and plays decisive role in different stages tumorigenesis, including initiation, promotion, progression, metastasis resistance to antitumor therapies. Colorectal disease widely associated with local chronic inflammation. Additionally, extrinsic factors such as infection may beneficially or detrimentally alter progression. Several reports have noted the ability various parasitic infections modulate development, favoring tumor...
Human Papillomavirus (HPV) in cervical epithelium has been identified as the main etiological factor developing of Cervical Cancer (CC), which recently become a public health problem Mexico. This finding allowed for development vaccines that help prevent this infection. In present study, we aimed to determine prevalence and HPV type-distribution Mexican women with CC, high-grade squamous intraepithelial lesion (HSIL), low-grade (LSIL), Normal cytology (N) estimate impact vaccines.The PubMed...
The aetiological relationship between human papillomavirus (HPV) infection and cervical cancer (CC) is widely accepted. Our goal was to determine the prevalence of HPV types in Mexican women attending at Institute for Social Security from different areas Mexico.DNAs 2,956 samples were subjected genotyping: 1,020 with normal cytology, 931 low-grade squamous intraepithelial lesions (LGSIL), 481 high grade HGSIL 524 CC.Overall 67.1%. A total 40 found; HPV16 detected 39.4% HPV-positive followed...
Colorectal cancer (CRC) is one of the most widespread and deadly types neoplasia around world, where inflammatory microenvironment has critical importance in process tumor growth, metastasis, drug resistance. Despite its limited effectiveness, 5-fluorouracil (5-FU) main utilized for CRC treatment. The combination 5-FU with other agents modestly increases effectiveness patients. Here, we evaluated anti-inflammatory Trimethylglycine Signal transducer activator transcription (STAT6) inhibitor...
Colon cancer (CC) is the third most common neoplasm and fourth cause of cancer-related death worldwide in both sexes. It has been established that inflammation plays a critical role tumorigenesis progression CC. Immune, stromal tumor cells supply microenvironment with pro-inflammatory cytokines such as interleukin 1β, TNFα, IL-6 IL-11, to hyperactivate signaling pathways linked cancerous processes. Recent findings suggest putative microRNAs (miRNAs) management inflammatory response...
Inflammation is a critical component of cancer development. Previously, we showed in vitro that IL-1β treatment non-invasive human breast MCF-7 cells promoted their transition to malignant phenotype (6D cells). This epithelial–mesenchymal was reverted by exposure cannabidiol (CBD). We show murine model subcutaneous inoculation 6D induced formation and development tumors, the which keep traits malignancy. These processes were interrupted administration CBD under two schemes: therapeutic...
Colorectal cancer (CRC) is one of the most prevalent fatal neoplasias worldwide. Despite efforts to improve early diagnosis CRC, mortality rate patients still nearly 50%. The primary treatment strategy for CRC surgery, which may be accompanied by chemotherapy and radiotherapy. conventional first-line chemotherapeutic agent utilized 5-fluorouracil (5FU). However, it has low efficiency. Combination with leucovorin oxaliplatin or irinotecan improves effectiveness 5FU therapy. Unfortunately,...
Cervical cancer (CC) as other types, presents molecular deregulations, such the alterations of transcription factors. Krüppel-like factors (KLF) are a family transcriptional regulators. They involved in diverse cellular processes, proliferation, apoptosis, and angiogenesis among others. Here, we analyzed expression all 17 KLF members at messenger RNA (mRNA) level, protein two most commonly altered KLF5 KLF6 cervical tissues. Fifty-nine tissues ranging from normal tissue to CC were evaluated...
Colorectal cancer (CRC) remains one of the most commonly diagnosed and deadliest types worldwide. CRC displays a desmoplastic reaction (DR) that has been inversely associated with poor prognosis; less DR is better prognosis. This generates excessive connective tissue, in which cancer-associated fibroblasts (CAFs) are critical cells form part tumor microenvironment. CAFs directly involved tumorigenesis through different mechanisms. However, their role immunosuppression not well understood,...
SUMMARY: Aim Reduction in nitric oxide (NO) levels during kidney failure has been related to the reaction of NO with superoxide anions yield peroxynitrite which possesses biological activity responsible for renal damage. However, stimulation pathway ameliorates progression failure. Thus, it is unclear whether prevents or acts as compound cytotoxicity observed Methods We evaluated development animals that were wild type and deficient endothelial synthase (eNOS (−/−)) tested effects an...
Abstract Cervical cancer (CC) is associated with alterations in immune system balance, which primarily due to a shift from Th1 Th2 and the unbalance of Th17/Treg cells. Using silico DNA copy number analysis, we have demonstrated that ~20% CC samples exhibit gain 8q22.3 19q13.31; regions genome encodes KLF10 PSG genes, respectively. Gene expression studies there were no mRNA expression, whilst PSG2 −5 genes up-regulated by 1.76 3.97-fold respectively compared normal tissue controls. siRNA...
Aims The authors have previously reported that cellular retinol-binding protein 1 ( CRBP1 ) gene gain and its expression correlated significantly with survival in laryngeal carcinoma patients. hypothesised inactivation of the through CpG methylation is associated patient status expression. In this work, determine correlation clinical variables Methods promoter was assessed by specific PCR analysis tissue samples from larynx cancer specimens immunohistochemistry on paraffin embedded using...
The relationship between Human Papillomavirus (HPV) infection and conjunctiva cancer is controversial. HPV detection will provide more information about the role of this infectious agent in biology cancer. In present study, DNA extracted purified from 36 Conjunctival Squamous Cell Carcinomas (CSCC) was evaluated by PCR for sequences. results were correlated with clinical histopathological variables.The showed that 8 CSCC samples (22%); HPV16 sole type detected. Significant association found...