A5043018596- Alzheimer's disease research and treatments
- Olfactory and Sensory Function Studies
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Kruppel-like factors research
- Bioinformatics and Genomic Networks
- Neurogenesis and neuroplasticity mechanisms
- Cancer, Hypoxia, and Metabolism
- Nuclear Receptors and Signaling
- Parkinson's Disease Mechanisms and Treatments
- 3D Printing in Biomedical Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive System and Pregnancy
- Calcium signaling and nucleotide metabolism
- Viral-associated cancers and disorders
- Cardiovascular Function and Risk Factors
- Photochromic and Fluorescence Chemistry
- Cholinesterase and Neurodegenerative Diseases
- Ovarian cancer diagnosis and treatment
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Biological Research and Disease Studies
- Phytochemicals and Medicinal Plants
- Neurological diseases and metabolism
- GDF15 and Related Biomarkers
Universidad Nacional Autónoma de México
2022-2024
Hospital Angeles Clinica Londres
2024
Hospital Clínico de la Universidad de Chile
2021
Center for Research and Advanced Studies of the National Polytechnic Institute
2014-2020
Instituto Nacional de Psiquiatría
2013-2020
Instituto Politécnico Nacional
2015-2020
Centro de Investigación en Materiales Avanzados
2017
Cervical cancer (CC) is a public health concern related to the human papillomavirus (HPV) persistent infection. Minichromosome maintenance 2 (MCM2) has been postulated as surrogate marker for HPV Thymopoietin (TMPO) nuclear protein regulated by E2F such MCM2 or p16. TMPO can give rise six different isoforms. Herein, both mRNA and levels of isoforms were analyzed in cervical cells. expression was selected through silico several databases from healthy cervix lesions. RNA evaluated samples cell...
Abstract Cervical cancer (CC) is associated with alterations in immune system balance, which primarily due to a shift from Th1 Th2 and the unbalance of Th17/Treg cells. Using silico DNA copy number analysis, we have demonstrated that ~20% CC samples exhibit gain 8q22.3 19q13.31; regions genome encodes KLF10 PSG genes, respectively. Gene expression studies there were no mRNA expression, whilst PSG2 −5 genes up-regulated by 1.76 3.97-fold respectively compared normal tissue controls. siRNA...
Similarities between the pathologic progression of cancer and physiologic process placentation have been recognized for many years proposing that both present similar mechanisms processes. Cervical (CC) is one most frequent neoplasia among Mexican women turning it into an important health problem.The aim this study was to determine degree involvement pregnancy related genes in by in-silico analysis validated CC samples.The data mining resulted identification expressed term placenta, first...
Tonsillar Kaposi sarcoma is rare, reported in patients with human immunodeficiency virus (HIV) infection. This case report of a tonsillar (KS) an HIV-negative male patient, initially misinterpreted as lingual lesion diagnosed KS following tonsillectomy, highlights the value differential diagnosis atypical presentations. The discusses etiologic agent KS, its detection and treatment, few reports about no association AIDS. underscores diagnostic challenge oropharyngeal lesions, particularly...
Von Hippel-Lindau disease (VHL) is a multiple organ neoplastic syndrome with autosomal dominant transmission, complete penetrance, and variable expression caused by mutations in the VHL gene. Although hereditary many cases, new cause up to 20 % of incidence. Mutations may development cysts tumors organs, including brain spinal cord hemangioblastoma, renal cell carcinoma (RCC), retinal heman-gioblastoma (RH), pheochromocytoma, epididymal broad ligament cystadenomas, endo-lymphatic sac tumor,...
La parálisis supranuclear progresiva (PSP) es un parkinsonismo atípico poco común, caracterizado por la presencia de agregados proteína tau y determinado amplio espectro características clínicas. El diagnóstico definitivo post mortem se identifica a través muerte neuronal, gliosis presentados en forma marañas neurofibrilares con apariencia globosa regiones como el núcleo subtalámico, sustancia nigra globo pálido. Los hallazgos los estudios imagen biomarcadores fluidos no son suficientes para...
Abstract Background Longitudinal population‐based studies have consistently revealed an expedited cognitive decline in the elderly population with type 2 diabetes mellitus (DM2). Additionally, there is a documented increased risk of developing vascular dementia and Alzheimer’s disease individuals DM2. Conversely, recent research has pointed to metformin (MET), widely prescribed medication for (T2DM), potentially mitigating age‐related dysfunction (Madhu et al., 2022). To explore this...
Abstract Background Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and insulin resistance. Historically, it linked to greater cognitive decline risk of Alzheimer's dementia. Although deregulations in the signaling pathway have been identified, further investigation needed. Diabetic patients over 60 years age, addition facing risks, show olfactory deficits like AD. Neuronal precursors epithelium (hONE NPCs) offer a valuable model for studying connection between T2DM Nasal...
Abstract Background Mild cognitive impairment may increase the risk of Alzheimer's disease (AD) or probably accelerate progression. AD is most common cause dementia, substantial neuronal loss, and neuropathological lesions can damage many brain regions. Symptoms begin with mild memory difficulties evolve towards impairment. Novel biomarkers include PET scans plasma assays for amyloid β phosphorylated tau, which show great promise clinical research use, but be expensive approaches, here we...
Abstract Background Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause of dementia in elderly. AD characterized by short‐term to long‐term memory loss, confusion, mood changes, language difficulties. Numerous studies have focused on dysregulated genes AD, but pathogenesis still unknown. The underlying risk factors remain largely unclear. discovery more accurate biomarkers will allow early detection development new treatments. Recently bioinformatics has become...
Alzheimer's disease is a neurodegenerative disorder whose etiology continues to be discussed, the point that there are different hypotheses seek clarify it, in addition fact that, given its multifactorial nature, risk factors associated with development.As regards diagnosis, advances molecule detection techniques at femtomolar scales have allowed distinguish between healthy and diseased subjects relatively early stages, although still much done.Aducanumab monoclonal antibody targeted against...
Alzheimer's disease is a neurodegenerative disorder whose etiology continues to be discussed, the point that there are different hypotheses seek clarify it, in addition fact that, given its multifactorial nature, risk factors associated with development. As regards diagnosis, advances molecule detection techniques at femtomolar scales have allowed distinguish between healthy and diseased subjects relatively early stages, although still much done. Aducanumab monoclonal antibody targeted...
Las enfermedades neuropsiquiátricas (ENP) se caracterizan por cambios en la plasticidad cerebral que incluyen pérdida neuronal regiones específicas el encéfalo, transmisión sináptica originada alteraciones los contactos sinápticos y también expresión de genes. Además, otro proceso forma parte encuentra afectado las ENP es generación nuevas neuronas (neurogénesis). El neurogénico adulto regulado manera fina diversos factores como aspectos genéticos, celulares, microambiente, elementos...
Cell homeostasis is maintained by the tight regulation of two major proteolytic systems: Autophagy and proteasome; an imbalance between these degradation systems results in accumulation protein aggregates that interfere with cell function. It has been reported neurodegenerative diseases such as Alzheimer's disease (AD), there are alterations levels growth factors a stress micro-environment. Neurotrophic bFGF had role proliferation; differentiation survival NPCs. Tau microtubule associated...
Amyloid Beta (Ab) is a peptide generated by the amyloidogenic pathway of APP processing. Although Ab peptides are produced at high amounts in pathological conditions, they also present low levels normal brains. It not clear role non-pathological conditions. Monomeric undergoes conformation transitions and proceeds to form molecular oligomers (dimer/trimer), then soluble aggregates progress spherical which composed 12 24 monomers, prolong protofibrils finally become insoluble fibrils. At...