Alzheimer’s disease (AD), a neurodegenerative disorder that can occur in middle or old age, is characterized by memory loss, continuous decline thinking, behavioral and social skills affect the ability of an individual to function independently. It divided into sporadic familial subtypes. Early-onset AD (FAD) linked mutations genes coding for amyloid-β protein precursor ( A β PP ), presenilin 1 PS1 2 PS2 which lead alterations AβPP processing, generation Amyloid-β peptide...

Las habilidades socioemocionales (HSE) son cruciales para ayudar a los individuos comprender y regular sus emociones, fomentar la empatía, construir relaciones positivas tomar decisiones responsables. Este documento expone percepción de profesores sobre un programa formación docente en línea el desarrollo HSE aula. El diseño curricular se estructuró utilizando modelo ADDIE (análisis, diseño, desarrollo, intervención evaluación), paradigma aprendizaje seguido es constructivismo. La evaluación...

Tonsillar Kaposi sarcoma is rare, reported in patients with human immunodeficiency virus (HIV) infection. This case report of a tonsillar (KS) an HIV-negative male patient, initially misinterpreted as lingual lesion diagnosed KS following tonsillectomy, highlights the value differential diagnosis atypical presentations. The discusses etiologic agent KS, its detection and treatment, few reports about no association AIDS. underscores diagnostic challenge oropharyngeal lesions, particularly...

Abstract Background Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause of dementia in elderly. AD characterized by short‐term to long‐term memory loss, confusion, mood changes, language difficulties. Numerous studies have focused on dysregulated genes AD, but pathogenesis still unknown. The underlying risk factors remain largely unclear. discovery more accurate biomarkers will allow early detection development new treatments. Recently bioinformatics has become...

Alzheimer's disease is a neurodegenerative disorder whose etiology continues to be discussed, the point that there are different hypotheses seek clarify it, in addition fact that, given its multifactorial nature, risk factors associated with development.As regards diagnosis, advances molecule detection techniques at femtomolar scales have allowed distinguish between healthy and diseased subjects relatively early stages, although still much done.Aducanumab monoclonal antibody targeted against...

Alzheimer's disease is a neurodegenerative disorder whose etiology continues to be discussed, the point that there are different hypotheses seek clarify it, in addition fact that, given its multifactorial nature, risk factors associated with development. As regards diagnosis, advances molecule detection techniques at femtomolar scales have allowed distinguish between healthy and diseased subjects relatively early stages, although still much done. Aducanumab monoclonal antibody targeted...

Cell homeostasis is maintained by the tight regulation of two major proteolytic systems: Autophagy and proteasome; an imbalance between these degradation systems results in accumulation protein aggregates that interfere with cell function. It has been reported neurodegenerative diseases such as Alzheimer's disease (AD), there are alterations levels growth factors a stress micro-environment. Neurotrophic bFGF had role proliferation; differentiation survival NPCs. Tau microtubule associated...

Amyloid Beta (Ab) is a peptide generated by the amyloidogenic pathway of APP processing. Although Ab peptides are produced at high amounts in pathological conditions, they also present low levels normal brains. It not clear role non-pathological conditions. Monomeric undergoes conformation transitions and proceeds to form molecular oligomers (dimer/trimer), then soluble aggregates progress spherical which composed 12 24 monomers, prolong protofibrils finally become insoluble fibrils. At...

Neurodegenerative diseases such as Alzheimer's disease are characterized by alterations in growth factor levels and a stress environment. Neurotrophic factors basic Fibroblast (bFGF) had role proliferation; differentiation survival of NPCs. NPCs pluripotent cells that can give rise to all 3 types the Central Nervous System. Studies potential particular interest due its biomedical implications cell therapy. It has been proposed chemical stimulus like acidic environment could reprogram somatic...

NPCs are pluripotent cells of CNS. Neurotrophic factors had a role in proliferation; differentiation and survival. Alzheimer’s disease is characterized by alterations growth factor levels stress environment. Cells recycle their components throw Autophagy or proteasome. An imbalance between these degradation systems results accumulation protein aggregates. It known that chemical stimulus (acidic environment) could reprogram somatic cells. To elucidate the impact on neural differentiation,...

Abstract Background 3D‐cell cultures are closer to in vivo conditions than the monolayers. There different culture models, most relevant is Cerebral Organoids (CO) model (Lancaster et al. 2014), it can show complex processes and proved molecular structural changes when modeling Alzheimer´s disease (AD), other diseases. One of main limitations using this requirement for Induced Pluripotent Stem Cells (iPSC) or Human Embryonic (hESC) CO generation; because iPSC could undergo epigenetic during...

The pH balance is essential for cell survival, slight variations had a great impact on the fate of undifferentiated cells (Ying et.al., 1999). Autophagy major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in lysosome plays pivotal role maintaining homeostasis defending against adverse microenvironments. There different stimuli that can trigger autophagy, nutrient deprivation most common one. We have previously reported absence bFGF enough cause...

DPSCs are adult mesenchymal cells, with capacity to differentiate into different lineages. Its survival depends on growth factors. The goal of cell therapy is promote regeneration damaged tissue by stem implants or activating the resident cells. In neurodegenerative diseases, such as Alzheimer's disease there a reduction in cells and factors (Tapia-Arancibia et.al., 2008). Since share similarities neural crest it can neuronal Neurotrophins participate development, differentiation,...

Alzheimer's disease (AD) is the most common type of dementia. Which pathophysiological characterized by extracellular presence amyloid plaques composed Amyloid Beta peptide (AB) and intracellular neurofibrillary tangles conformed hyperphosphorylated tau protein. Fibroblasts patients with familial AD have being shown AB42 elevation deficiency in autophagic/lysosome pathway, dysfunctional accumulation mitochondria, which could be confirmed neurons derived from induced pluripotent stem cells...

Spanish Abstract: El texto representa una revisión de los principales mecanismos regulación GPCRs y proteínas G Heterotriméricas. Se comparte como un lectura para curso Transducción Señales, Capítulo estudio heterotriméricas sección “Transducción Señales”, Receptores Acoplados a Proteínas HeterotriméricasEnglish The text represents review of the main regulatory mechanisms and Heterotrimeric proteins. It is shared as reading for Signal Transduction course, Chapter study heterotrimeric...

Spanish Abstract: El presente capítulo forma parte de la serie "Transducción señales". documento describe los mecanismos involucrados en regulación las GTPasas pequeñas.English This chapter is part of the series "Signal transduction". The document describes mechanisms involved in regulation small GTPases.

Abstract Background Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss, neuronal degeneration and synaptic dysfunction, resulting in atrophy of the affected regions. The identification early biomarkers for AD diagnosis has been challenge due to high individual variability markers expression, thus use peripheral cells other than such as bone marrow or dental pulp mesenchymal cells, blood fibroblasts represents an opportunity detection pathological changes...

Alzheimer’s disease (AD) is neurodegeneration that accounts for 60–70% of dementia cases. Symptoms begin with mild memory difficulties and evolve towards cognitive impairment. The underlying risk factors remain primarily unclear this heterogeneous disorder. Bioinformatics a relevant research tool allows identifying several pathways related to AD. Open-access databases RNA microarrays from the peripheral blood brain AD patients were analyzed after background correction data normalization;...

Abstract Background Alzheimer's disease (AD) is a neurodegeneration that accounts for 60‐70% of dementia cases. Symptoms begin with mild memory difficulties and evolve towards cognitive impairment. The underlying risk factors remain largely unclear this heterogeneous disorder. Discovery AD biomarkers will allow early detection the discovery new treatments. Bioinformatics has become relevant research tool which have led to identification several pathways related AD. Method Open access...

The accumulation and aggregation of misfolded proteins in the human brain are known to be an essential feature many neurodegenerative diseases, presenilin-1 (PS1) mutations linked Alzheimer's disease (AD) have been suggested alter protein response (UPR) due stress on endoplasmic reticulum. Moreover, deal with generated by aggregation, cells use a series protection mechanisms. One these biological responses involves called molecular chaperones that mediate folding, signaling, surveillance,...