A5008990477- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Neurogenesis and neuroplasticity mechanisms
- Olfactory and Sensory Function Studies
- Bioinformatics and Genomic Networks
- Nerve injury and regeneration
- Nuclear Receptors and Signaling
- RNA Research and Splicing
- Parkinson's Disease Mechanisms and Treatments
- RNA Interference and Gene Delivery
- Peroxisome Proliferator-Activated Receptors
- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- Calcium signaling and nucleotide metabolism
- Mitochondrial Function and Pathology
- Computational Drug Discovery Methods
- Neurological disorders and treatments
- Lysosomal Storage Disorders Research
- Pluripotent Stem Cells Research
- Cancer, Hypoxia, and Metabolism
- Dementia and Cognitive Impairment Research
- 3D Printing in Biomedical Research
- Biological Research and Disease Studies
- GDF15 and Related Biomarkers
- Heme Oxygenase-1 and Carbon Monoxide
Universidad Nacional Autónoma de México
2003-2025
Center for Research and Advanced Studies of the National Polytechnic Institute
2003-2016
New York State Office for People With Developmental Disabilities
2010-2015
Instituto Politécnico Nacional
2014-2015
University of York
2013
The level of brain-derived neurotrophic factor (BDNF), a member the neurotrophin family, is down regulated in Alzheimer's disease (AD), Parkinson's (PD), depression, stress, and anxiety; conversely this increased autism spectrum disorders. Thus, modulating BDNF can be potential therapeutic approach for nervous system pathologies. In present study, we designed five different tetra peptides (peptides B-1 to B-5) corresponding active regions BDNF. These were found non-toxic, they induced...
The α-synucleinopathies constitute a subset of neurodegenerative disorders, which Parkinson's disease (PD) is the most common worldwide, characterized by accumulation misfolded α-synuclein in cytoplasm neurons, spreads prion-like manner to anatomically interconnected brain areas. However, it not clear how α-synucleinopathy triggers neurodegeneration. We recently developed rat model through single intranigral administration neurotoxic β-sitosterol β-D-glucoside (BSSG), produces...
Aims Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive degeneration of dopaminergic neurons in substantia nigra pars compacta, leading to impaired dopamine (DA) signaling and motor control. Intermittent dosing current DA precursors results side effects, prompting research into controlled drug release mechanisms for sustained targeted delivery DA.
We have previously reported that the antioxidant curcumin exerts nephroprotection in maleate-induced renal damage, a model associated with oxidative stress. However, mechanisms involved protective effect were not explored, to assess this issue, was administered daily by gavage (150 mg/kg) five days before single maleate (400 mg/kg)-injection. Curcumin prevented proteinuria, increased heat shock protein of 72 KDa (Hsp72) expression, and decreased plasma glutathione peroxidase activity....
Abstract Neural stem cell specification depends on antero‐posterior (AP) and dorso‐ventral (DV) information provided during development. In the present study we identified similar neural (NSC) populations along AP axis of mouse central nervous system: ‘early’ NSCs responsive to fibroblast growth factor‐2 ‘late’ epidermal factor (EGF). Gene expression analysis shows that DV transcription code is not preserved in culture. Neurospheres generated with EGF from different regions showed Emx2 , En2...
Although apoptosis has been considered the typical mechanism for physiological cell death, presently alternative mechanisms need to be considered. We previously showed that fibroblast growth factor-2 (FGF2) could act as a survival factor neural precursor cells. To study death activated by absence of this factor, we followed changes in morphology and determined viability staining with several dyes after FGF2 removal from mesencephalic neural-progenitor-cell cultures. The observed did not...
Autism is a neurodevelopmental disorder characterized clinically by impairments in social interaction and verbal non-verbal communication skills as well restricted interests repetitive behavior. It has been hypothesized that altered brain environment including an imbalance neurotrophic support during early development contributes to the pathophysiology of autism. Here we report sera from children with autism which exhibited abnormal levels various factors induced cell death oxidative stress...
The precise functional role of the dystrophin 71 in neurons is still elusive. Previously, we reported that 71d and 71f are present nuclei from cultured neurons. In work, performed a detailed analysis intranuclear distribution isoforms (Dp71d Dp71f), during temporal course 7-day postnatal rats hippocampal culture for 1h, 2, 4, 10, 15 21 days vitro (DIV). By immunofluorescence assays, detected highest level nuclear expression both Dp71 at 10 DIV, primary culture. Dp71d Dp71f were mainly...
RhoGDI proteins have been implicated in several human cancers; changes their expression levels shown pro- or anti-tumorigenic effects. Pancreatic Ductal Adenocarcinoma (PDAC) is a complex pathology, with poor prognosis, and most patients die shortly after diagnosis. Efforts focused on understanding the role of RhoGDI's PDAC, specially, RhoGDI1 RhoGDI2. However, RhoGDI3 has not studied relation to cancer PDAC. Here, we characterized functionality its target GTPases, RhoG RhoB pancreatic cell...
Alzheimer’s disease (AD), a neurodegenerative disorder that can occur in middle or old age, is characterized by memory loss, continuous decline thinking, behavioral and social skills affect the ability of an individual to function independently. It divided into sporadic familial subtypes. Early-onset AD (FAD) linked mutations genes coding for amyloid-β protein precursor ( A β PP ), presenilin 1 PS1 2 PS2 which lead alterations AβPP processing, generation Amyloid-β peptide...
To determine the differential protein profiles of cervical cancer cell lines in order to find potential targets that can be used as biomarkers low-grade squamous intraepithelial lesions (LSIL) diagnosis.Proteomic analysis was performed on by 2D electrophoresis and liquid chromatography-mass spectrometry. Biomarker validation histological samples immunofluorescence.Aldo-keto reductase C1 (AKR1C1) transketolase-like 1 (TKTL1) proteins were selected their expression increased with LSIL...
Abstract Background Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and insulin resistance. Historically, it linked to greater cognitive decline risk of Alzheimer's dementia. Although deregulations in the signaling pathway have been identified, further investigation needed. Diabetic patients over 60 years age, addition facing risks, show olfactory deficits like AD. Neuronal precursors epithelium (hONE NPCs) offer a valuable model for studying connection between T2DM Nasal...
Abstract Background Mild cognitive impairment may increase the risk of Alzheimer's disease (AD) or probably accelerate progression. AD is most common cause dementia, substantial neuronal loss, and neuropathological lesions can damage many brain regions. Symptoms begin with mild memory difficulties evolve towards impairment. Novel biomarkers include PET scans plasma assays for amyloid β phosphorylated tau, which show great promise clinical research use, but be expensive approaches, here we...
Von Hippel-Lindau disease (VHL) is a multiple organ neoplastic syndrome with autosomal dominant transmission, complete penetrance, and variable expression caused by mutations in the VHL gene. Although hereditary many cases, new cause up to 20 % of incidence. Mutations may development cysts tumors organs, including brain spinal cord hemangioblastoma, renal cell carcinoma (RCC), retinal heman-gioblastoma (RH), pheochromocytoma, epididymal broad ligament cystadenomas, endo-lymphatic sac tumor,...
Abstract Background Longitudinal population‐based studies have consistently revealed an expedited cognitive decline in the elderly population with type 2 diabetes mellitus (DM2). Additionally, there is a documented increased risk of developing vascular dementia and Alzheimer’s disease individuals DM2. Conversely, recent research has pointed to metformin (MET), widely prescribed medication for (T2DM), potentially mitigating age‐related dysfunction (Madhu et al., 2022). To explore this...
Nutritional intake is a fundamental determinant of health. It well known that cholesterol rich diets can induce several pathological conditions but detailed mechanism underlying these remains unknown. Wistar rats, an animal strain widely used in the research have been employed to study effects dietary interventions due their metabolic characteristics, which are closer human compared mice. The effect some components western diet, combined with lipid profile studied, impact only or fatty-acid...
Abstract Background Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause of dementia in elderly. AD characterized by short‐term to long‐term memory loss, confusion, mood changes, language difficulties. Numerous studies have focused on dysregulated genes AD, but pathogenesis still unknown. The underlying risk factors remain largely unclear. discovery more accurate biomarkers will allow early detection development new treatments. Recently bioinformatics has become...