OBJECTIVE Type 2 diabetes is the most common form of worldwide. Some its complications, such as retinopathy and neuropathy, are long-term protracted, with an unclear etiology. Given this problem, genetic model systems, in flies where type can be modeled studied, offer distinct advantages. RESEARCH DESIGN AND METHODS We used individual experiments: control mutant individuals partial loss-of-function insulin pathway genes. measured wing size tested body weight for growth phenotypes, latter by...

The calyxes of roselle (Hibiscus sabdariffa) are recognized for their high nutraceutical value because they decrease body weight and obesity complications. These effects have been attributed mainly to anthocyanins. However, the comprise important concentration flavonoids, phenolic, organic acids, which could also contribute these effects. objective this work was determine effect Alma Blanca white variety on hepatic steatosis in high-fat, high-fructose, diet-fed rats compare its beneficial...

Abstract —Kidney failure is the common end of hypertension and renal diseases. Several authors have suggested that vasodilatory prostaglandins participate in hemodynamic mechanism responsible for development kidney failure. However, by which are increased disease not clear. Recently, 2 isoforms enzyme prostaglandin synthesis, cyclooxygenase, been described as cyclooxygenase-1 (COX-1), a constitutive isoform, cyclooxygenase-2 (COX-2), an inducible isoform. In present study, we investigated...

ABSTRACT As a molecular marker for head specification in Hydra, we have cloned an epithelial cell-specific gene which responds to early signals of formation. The gene, designated ks1, encodes 217-amino acid protein lacking significant sequence similarity any known protein. KS1 contains N-terminal signal and is rich charged residues are clustered several domains. ks1 expressed tentacle-specific cells (battery cells) as well small fraction ectodermal the gastric region subjacent tentacles....

In colon cancer, disturbances have been detected in genes coding for proteins involved cellular proliferation, such as K-ras, β-catenin, extracellular signal-regulated kinases (ERKs), and the protein kinase B (PKB). Although carotenoids lutein an important role to prevent treat some types of there are very few studies about effect against cancer its activity at molecular level. Therefore, aim this study was evaluate chemoprotective induced by dimethylhydrazine (DMH). The results showed a...

It has been recognised recently that obese individuals have lower concentrations of micronutrients and this may affect the inflammatory cytokines. A cross-sectional study was carried out to evaluate association specific micronutrients' status with chronic inflammation caused by obesity in 280 women (36·1 (SD 7·5) years) from seven rural communities Mexico. Measurements weight, height waist circumference were made on all body composition determined dual-energy X-ray absorptiometry....

A high saturated fat and fructose diet leads to metabolic disorders through dysregulation of genes involved in lipid metabolism.

The accumulation of (beta)-carotene by the zygomycete Phycomyces blakesleeanus is increased mutations in carS gene. treatment spores mutants with N-methyl-N(prm1)-nitro-N-nitrosoguanidine led to isolation, at very low frequencies, that produced higher levels (beta)-carotene. Strain S556 about 9 mg per g dry mass when it was grown on minimal agar. Crosses involving strain separated original mutation from a new, unlinked mutation, carF. carF segregants approximately as much carotene did...

Although apoptosis has been considered the typical mechanism for physiological cell death, presently alternative mechanisms need to be considered. We previously showed that fibroblast growth factor-2 (FGF2) could act as a survival factor neural precursor cells. To study death activated by absence of this factor, we followed changes in morphology and determined viability staining with several dyes after FGF2 removal from mesencephalic neural-progenitor-cell cultures. The observed did not...

Different signaling systems coordinate and regulate the development of a multicellular organism. In hydra, canonical Wnt pathway signal transduction pathways mediated by PKC Src early stages head formation. this paper, we present evidence for participation third pathway, PI3K‐PKB involved in process. The data presented here are consistent with ERK 1‐2 as point convergence PKC, PI3K regulation regeneration hydra. specific developmental regulated them appears to be commitment tissue at apical...

Grape pomace is a commonly discarded by-product characterized by high extractable (EPP) and non-extractable (NEPP) polyphenol contents which exhibits anti-obesogenic effects. However, the relevance of each fraction needs to be elucidated. In this work, we examined effects three pomaces with different concentrations EPPs NEPPs on metabolic alterations associated obesity. The NEPP:EPP ratio grape was 1.48 for Malbec, 1.10 Garnacha, 5.76 Syrah varieties. Rats fed high-fat high-fructose diet...

Native plants are exceedingly valuable because they sources of natural products with applications for the treatment various diseases. Berrycactus fruit (Myrtillocactus geometrizans) has been consumed in Mexico since ancient times due to its sweetness. The hypoglycemic and antioxidant effects this were evaluated streptozotocin-induced diabetic rats by replacing drinking water berrycactus juice (2 or 4 g/kg). After weeks treatment, animals showed an improvement their conditions, as reflected...

Xylanases, an important group of enzymes for biomass degradation in the industry, are commonly found forming complex multienzyme systems. As a preliminary step to construction efficient xylanase producers using genetic engineering, we have characterized gene encoding endo-beta-1,4 (xyncflA) from Cellulomonas flavigena. The activity and xyncflA synthesis were higher when C. flavigena was grown on sugarcane bagasse. In this substrate, both transcript increased with approximately same rate...