A5053286373- Phytochemicals and Antioxidant Activities
- Food composition and properties
- Natural Antidiabetic Agents Studies
- Genomics, phytochemicals, and oxidative stress
- Diet, Metabolism, and Disease
- Sirtuins and Resveratrol in Medicine
- Antioxidant Activity and Oxidative Stress
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Phytoestrogen effects and research
- Tea Polyphenols and Effects
- Microbial Metabolites in Food Biotechnology
- Phytase and its Applications
- Seed and Plant Biochemistry
- Glutathione Transferases and Polymorphisms
- Genetics, Aging, and Longevity in Model Organisms
- Botanical Research and Applications
- Mycotoxins in Agriculture and Food
- Cardiovascular Disease and Adiposity
- Coconut Research and Applications
- Natural product bioactivities and synthesis
- Biochemical Acid Research Studies
- Tannin, Tannase and Anticancer Activities
- Essential Oils and Antimicrobial Activity
- Heavy Metals in Plants
Autonomous University of Queretaro
2016-2025
Instituto Tecnológico Superior de Xalapa
2017
Agriculture and Agri-Food Canada
2011
Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias
2008
Johns Hopkins University
1999-2004
University of Tsukuba
2001
Induction of phase 2 enzymes, which neutralize reactive electrophiles and act as indirect antioxidants, appears to be an effective means for achieving protection against a variety carcinogens in animals humans. Transcriptional control the expression these enzymes is mediated, at least part, through antioxidant response element (ARE) found regulatory regions their genes. The transcription factor Nrf2, binds ARE, essential induction prototypical such glutathione S -transferases (GSTs)...
The cancer chemopreventive actions of oltipraz (4-methyl-5-[2-pyrazinyl]-1,2-dithiole-3-thione) have been primarily associated with the induction phase 2 detoxifying enzymes through transcriptional activation antioxidant response element (ARE) in promoter regions these genes. transcription factor Nrf2 has shown to bind and activate AREs. Previously, we demonstrated that nrf2 -deficient mice had low basal expression were substantially more susceptible benzo[ a ]pyrene (B[ ]P)-induced...
Common beans ( Phaseolus vulgaris L.) contain a high proportion of undigested carbohydrates (NDC) that can be fermented in the large intestine to produce short-chain fatty acids (SCFA) such as acetate, propionate, and butyrate. The objective present study was evaluate composition chemopreventive effect polysaccharide extract (PE) from cooked common P. L) cv. Negro 8025 on azoxymethane (AOM) induced colon cancer rats. PE SCFA production with highest butyrate concentrated cecum zone: 6.7 +/-...
The methanolic extract of Cnidoscolus chayamansa leaves from Mexico was screened for antioxidant and antimutagenic properties by the DPPH, ABTS, iron chelating, Kado microsuspension assays, respectively. hypoglycemic effect also studied. Total phenolic flavonoid contents as well HPLC identification quantification protocatechuic acid rutin were carried out. C. contained 71.3 +/- 1.7 mg gallic equivalent/g 42.6 3.7 (+)-catechin total phenols flavonoids, Concentrations 0.242 0.001 mg/g 2.00...
The incorporation of copper ions into the cytosolic superoxide dismutase (SOD1) is accomplished in vivo by action metallochaperone CCS (copper chaperone for SOD1). Mammalian comprised three distinct protein domains, with a central region exhibiting remarkable homology (approximately 50% identity) to SOD1 itself. Conserved are all zinc binding ligands and four histidine ligands. In fourth replaced an aspartate (Asp200). Despite this conservation sequence between CCS, exhibited no detectable...
The non-digestible fraction (NDF) of common bean (Phaseolus vulgaris L.) cultivar Bayo Madero was evaluated for its chemopreventive effect on azoxymethane (AOM) induced aberrant crypt foci (ACF) in rats. Diets containing cooked beans (CB) or were fed to 72 male rats after 2 injections (15 mg kg(-1) body weight once a week weeks). ACF number, short chain fatty acids (SCFA) and β-glucuronidase activity measured colon sections from sacrificed 7 weeks the last AOM injection. Food intake gain...
The objective of this work was to study the formation resistant starch (RS) in tortillas from an ecological nixtamalization process compared with traditional process. RS increased through all steps tortilla production. It found that increase corresponds mainly RS5 (V‐amylose‐lipid complex), but two major types coexist: and RS3 (retrograded starch). In general, gave higher values protein, lipids, total dietary fiber, insoluble soluble commercial flour. highest glycemic index (GI) occurred...
Metabolism of the nondigested fraction (NDF) from common bean ( Phaseolus vulgaris L.) by human gut flora (hgf) produces short-chain fatty acids (SCFAs) that may benefit cancer reducing colorectal tumor risks. This paper reports effect fermentation products (FP) hgf (FP-hgf) NDF cooked beans on survival and protein expression associated with apoptosis, cell cycle arrest, proliferation in adenocarcinoma colon cells. FP-hgf was only inoculum eliciting butyrate production after 24 h using...
The aim of the present study was to evaluate synergic effect lycopene (LYC) treatment with a dietary control in nonalcoholic fatty liver disease (NAFLD) model induced high-fat diet (HFD). Sprague-Dawley rats were fed during 4 weeks normal (ND·4w) or an HFD (HFD·4w) produce NAFLD model. Then, from ND·4w group continued same (ND·8w), and ND (HFD·4w+ND·4w) plus LYC (HFD·4w+ND+LYC·4w). (20 mg/kg) administered daily by gavage. ND+LYC diets partially reverted following alterations due HFD: weight,...
The consumption of fruits, vegetables, nuts, legumes, and whole grains has been associated with a lower risk colorectal cancer (CRC) due to the content natural compounds antioxidant anticancer activities. oat (Avena sativa L.) is unique source avenanthramides (AVAs), among other compounds, chemopreventive effects. In addition, germination shown enhanced nutraceutical phytochemical properties. Therefore, our objective was evaluate effect sprouted (SO) its phenolic-AVA extract (AVA) in...
In colon cancer, disturbances have been detected in genes coding for proteins involved cellular proliferation, such as K-ras, β-catenin, extracellular signal-regulated kinases (ERKs), and the protein kinase B (PKB). Although carotenoids lutein an important role to prevent treat some types of there are very few studies about effect against cancer its activity at molecular level. Therefore, aim this study was evaluate chemoprotective induced by dimethylhydrazine (DMH). The results showed a...
The aim of the present study was to investigate antidiabetic potential aqueous chaya extract (Cnidoscolus spp.) in streptozotocin-induced diabetic rats. Compounds identified and quantified included flavonoids phenolic acids, addition saponins alkaloids, among others. Several new compounds (coutaric, vanillic, rosmarinic hesperidin), (phytolaccagenic oleanolic hederagenin derivatives) alkaloids (choline, trigonelline, sitsirikine), were identified. In vivo studies showed that a 4-week...