A5016681940- Parasitic infections in humans and animals
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Helicobacter pylori-related gastroenterology studies
- Parasitic Infections and Diagnostics
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Reproductive System and Pregnancy
- Parasites and Host Interactions
- Colorectal Cancer Treatments and Studies
- Inflammatory Bowel Disease
- Macrophage Migration Inhibitory Factor
- Eosinophilic Esophagitis
- Chemokine receptors and signaling
- Amoebic Infections and Treatments
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Color perception and design
- T-cell and B-cell Immunology
- Apelin-related biomedical research
- Nuclear Receptors and Signaling
- Lipid metabolism and disorders
- Adipose Tissue and Metabolism
Universidad Nacional Autónoma de México
2014-2024
Autonomous University of Tlaxcala
2014-2024
Centro de Investigación Biomédica en Red
2021
Universidad Autónoma Metropolitana
2013
Universidad Nacional de Colombia
2003-2010
Obstructive sleep apnea (OSA) has been related to elevation of inflammatory cytokines and development insulin resistance in morbidly obese (MO) subjects. However, it is still unclear whether the systemic concentration anti‐inflammatory mediators also affected MO subjects directly severity OSA level resistance. Normal weight were subjected overnight polysomnography order establish OSA, according apnea‐hypopnea index (AHI). Blood samples obtained for estimation total cholesterol triglycerides,...
Leptin is an adipose tissue-derived hormone that has been involved in hypothalamic and systemic inflammation, altered food-intake patterns, metabolic dysfunction obese mice. However, it remains unclear whether leptin a relationship with parameters of inflammation humans. We thus evaluated cross-sectional study the circulating levels 40 non-obese 41 Mexican individuals, examining their tumor necrosis factor alpha (TNF-a), interleukin (IL) 12, IL-10, central obesity, serum glucose insulin...
Abstract Colitis-associated colon cancer (CAC) is one of the most common malignant neoplasms and a leading cause death. The immunologic factors associated with CAC development are not completely understood. Signal transducer activator transcription 6 (STAT6) part an important signaling pathway for modulating intestinal immune function homeostasis. However, role STAT6 in progression unclear. Following induction wild-type (WT) STAT6-deficient mice (STAT6–/–), we found that 70% STAT6–/– were...
Interleukin-(IL-) 12 has been recently suggested to participate during development of insulin resistance in obese mice. Nevertheless, serum IL-12 levels have not accurately determined overweight and humans. We thus studied concentrations Mexican adult individuals, examining their relationship with low-grade inflammation obesity-related parameters. A total 147 healthy 43 normal weight, 61 overweight, subjects participated the study. Circulating IL-12, tumor necrosis factor-alpha (TNF- α ),...
Chronic inflammation of the intestinal mucosa is characteristic inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease. Helminth parasites have developed immunomodulatory strategies that may impact outcome several diseases. Therefore, we investigated whether Taenia crassiceps infection able to decrease effects dextran sulfate sodium- (DSS-) induced in BALB/c C57BL/6 mice. Preinfection significantly reduced manifestations DSS-induced colitis, weight loss shortened colon...
Colorectal cancer (CRC) is the second most commonly diagnosed in women and third men North America Europe. CRC associated with inflammatory responses which intestinal pathology caused by different cell populations including a T dysregulation that concludes an imbalance between activated (Tact) regulatory (Treg) cells. Treg cells are CD4+Foxp3+ actively suppress pathological physiological immune responses, contributing to maintenance of homeostasis. A tumor-promoting function for has been...
Inflammation is currently considered a hallmark of cancer and plays decisive role in different stages tumorigenesis, including initiation, promotion, progression, metastasis resistance to antitumor therapies. Colorectal disease widely associated with local chronic inflammation. Additionally, extrinsic factors such as infection may beneficially or detrimentally alter progression. Several reports have noted the ability various parasitic infections modulate development, favoring tumor...
Colorectal cancer (CRC) is one of the most widespread and deadly types neoplasia around world, where inflammatory microenvironment has critical importance in process tumor growth, metastasis, drug resistance. Despite its limited effectiveness, 5-fluorouracil (5-FU) main utilized for CRC treatment. The combination 5-FU with other agents modestly increases effectiveness patients. Here, we evaluated anti-inflammatory Trimethylglycine Signal transducer activator transcription (STAT6) inhibitor...
Robust data in animals show that sucralose intake during gestation can predispose the offspring to weight gain, metabolic disturbances, and low-grade systemic inflammation; however, concluding information remains elusive humans. In this cross-sectional, prospective study, we examined birth weight, glucose insulin cord blood levels, monocyte subsets, inflammatory cytokine profile 292 neonates at term from mothers with light ingestion (LSI) of less than 60 mg sucralose/week or heavy (HSI) more...
Cirrhosis is the final outcome of liver fibrosis.Kupffer cell-mediated hepatic inflammation considered to aggravate injury and fibrosis.Alternatively-activated macrophages are able control chronic inflammatory events trigger wound healing processes.Nevertheless, role alternative Kupffer cell activation in harm largely unclear.Thus, we evaluated participation alternatively-activated cells during fibrosis murine model carbon tetrachloride-induced damage.To stimulate cells, 20 Taenia crassiceps...
Colitis-associated colorectal cancer (CAC) is one of the most common cancers and closely related to chronic or deregulated inflammation.Helminthic infections can modulate inflammatory responses in some diseases, but their immunomodulatory role during development remains completely unknown.We have analyzed Taenia crassiceps-induced anti-inflammatory response determining outcome CAC.We show that extraintestinal T. crassiceps infection CAC mice inhibited colonic tumor formation prevented goblet...
Signal transducer and activator of transcription 1 (STAT1) is part the Janus kinase (JAK/STAT) signaling pathway that controls critical events in intestinal immune function related to innate adaptive immunity. Recent studies have implicated STAT1 tumor–stroma interactions, its expression activity are perturbed during colon cancer. However, role initiation inflammation-associated cancer not clearly understood. To determine colitis-associated colorectal (CAC), we analyzed tumor development...
Colorectal cancer (CRC) is an important health issue worldwide, accounting for the third place of incidence.Chronic inflammation, as seen in Crohn's disease and ulcerative colitis, most risk factor developing CRC, it favours neoplastic transformation by enhancing epithelial cell turnover colonic mucosa.Treatments CRC need to be improved; currently they are not specific have several secondary effects patients.The main objective this work was evaluate a new therapeutic strategy against...
Signal transducer and activator of transcription 6 (STAT6) promotes tumorigenesis by decreasing the Forkhead box P3+ (Foxp3+) cell frequency allowing for infiltration inflammatory cells during early stages colitis-associated cancer (CAC). In this study, we dissected role STAT6 in generation inducible vitro regulatory T (iTregs) peripheral vivo Tregs (pTregs) under conditions. assays, when was lacking, iTregs preserved a stable phenotype expressed high levels Foxp3 CD25 long expansion...
Inflammation is the main driver of tumor initiation and progression in colitis-associated colorectal cancer (CAC). Recent findings have indicated that signal transducer activator transcription 6 (STAT6) plays a fundamental role early stages CAC, STAT6 knockout (STAT6−/−) mice are highly resistant to CAC development. Regulatory T (Treg) cells play major coordinating immunomodulation cancer; however, induction function Treg poorly understood. To clarify contribution STAT6−/− wild type (WT)...
Signal transducer and activator of transcription 1 (STAT1) acts as a tumor suppressor molecule in colitis-associated colorectal cancer (CAC), particularly during the very early stages, modulating immune responses controlling mechanisms such apoptosis cell proliferation. Previously, using an experimental model CAC, we reported increased intestinal proliferation faster development, which were consistent with more signs disease damage, reduced survival STAT1-/- mice, compared WT counterparts....
More than one quarter of human world's population is exposed to intestinal helminth parasites.The Taenia solium tapeworm carrier the main risk factor in transmission both neurocysticercosis and porcine cysticercosis.Sex steroids play an important role during T. infection, particularly progesterone has been proposed as a key immunomodulatory hormone involved susceptibility taeniosis woman cysticercosis pregnant pigs.Thus, we evaluated effect administration upon experimental golden hamsters...