A5023379162- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- RNA modifications and cancer
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Lung Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- BRCA gene mutations in cancer
- Cancer Mechanisms and Therapy
- Extracellular vesicles in disease
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Amoebic Infections and Treatments
- Chromatin Remodeling and Cancer
- Advanced Breast Cancer Therapies
- Nutrition, Genetics, and Disease
- Cancer Cells and Metastasis
Universidad Veracruzana
2023-2025
Instituto Nacional de Cancerología
2014-2023
Instituto Nacional de Cancerología
2012-2021
National Institute of Genomic Medicine
2017
Instituto Nacional de Enfermedades Respiratorias
2012
Fundación Santa Fe de Bogotá
2012
Tecnológico de Monterrey
2012
Centro de Investigación en Materiales Avanzados
2008-2010
To evaluate the effect of all-trans retinoic acid (ATRA) as treatment for chemotherapy-induced peripheral neuropathy in an experimental animal model and a randomized, double-blinded, controlled trial patients with non-small-cell lung cancer (NSCLC).Forty male Wistar rats were randomized 5 groups: group A, control; groups B C, treated cisplatin; D E, paclitaxel. ATRA (20 mg/kg PO) was administered 15 days C E. We evaluated nerve regeneration-related morphologic changes sciatic nerve,...
Since the International Association for Study of Lung Cancer (IASLC), American Thoracic Society (ATS) and European Respiratory (ERS) reported a new lung adenocarcinoma (ADC) classification, several groups have validated its association with prognosis in early stage disease. To our knowledge, there are no studies advanced We reviewed 313 patients invasive ADC who were re-classified using IASLC/ATS/ERS criteria. Patients received platinum-based chemotherapy. Clinical characteristics, EGFR...
Invasion and metastasis are determinant events in the prognosis of Colorectal cancer (CRC), a common neoplasm worldwide. An important factor for is acquired capacity cell to proliferate invade adjacent tissues. In this paper, we explored role micro-RNA-26a regulation proliferation migration CRC-derived cells through negative PTEN, key regulator AKT pathway.
Objetive: In patients with non–small cell lung cancer (NSCLC), knowledge of the epidermal growth factor receptor (EGFR) mutation status is fundamental for selecting treatment involving EGFR-tyrosine kinase inhibitors (EGFR-TKIs). Little information available regarding response and progression-free survival (PFS) in platinum-based chemotherapy (CT) versus EGFR-TKIs presence or absence KRAS mutation, particularly without EGFR mutation. Methods: From 2007 to 2010, 353 NSCLC were treated...
Metastatic breast cancer (MBC) is a challenge for oncologists, and public efforts should focus on identifying additional molecular markers therapeutic management to improve clinical outcomes. Among all diagnosed cases of (BC; approximately 10%) involve metastatic disease; notably, 40% patients with early‑stage BC develop metastasis within 5 years. The MBC consists systemic therapy. Despite different treatment options, the 5‑year survival rate <20%, which may be due lack response de novo or...
Abstract Chemotherapy activates a novel cytoplasmic DNA damage response resulting in Golgi apparatus fragmentation and cancer cell survival. This mechanism is regulated by phosphoprotein-3 (GOLPH3)/Myo18A/F-actin axis. Analyzing the functions of miR-3135b, small non-coding RNA with unknown functions, we found that its forced overexpression attenuates induced chemotherapeutic drugs colorectal (CRC) cells. First, miR-3135b downregulated CRC lines clinical tumors. Bioinformatic predictions...
Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide in both sexes. Current therapies include surgery, chemotherapy, and targeted therapy; however, prolonged exposure to chemical agents induces toxicity patients drug resistance. So, we implemented a therapeutic strategy based on combination doxorubicin, metformin, sodium oxamate called triple therapy (Tt). We found that Tt significantly reduced proliferation by inhibiting mTOR/AKT pathway promoted apoptosis...
The most frequently diagnosed histological types of cervical cancer (CC) are squamous cell carcinoma (SCC) and adenocarcinoma (ADC). Clinically, the prognosis both is controversial. A molecular profile that distinguishes each subtype predicts would be great benefit to CC patients. Methods: transcriptome patients from Cancer Genome Atlas (TCGA) was analyzed using DESeq2 package obtain differentially expressed genes (DEGs) between ADC SCC. DEGs were validated on a publicly available...
Colon cancer (CC) is the third most common neoplasm and fourth cause of cancer-related death worldwide in both sexes. It has been established that inflammation plays a critical role tumorigenesis progression CC. Immune, stromal tumor cells supply microenvironment with pro-inflammatory cytokines such as interleukin 1β, TNFα, IL-6 IL-11, to hyperactivate signaling pathways linked cancerous processes. Recent findings suggest putative microRNAs (miRNAs) management inflammatory response...
Neoadjuvant chemotherapy aims to improve the outcome of breast cancer patients, but only few would benefit from this treatment. Pathological complete response has been proposed as a surrogate marker for prediction long-term clinical benefits; however, 50%-85% patients have an unfavorable pathological chemotherapy. MicroRNAs are known biomarkers progression; nevertheless, their potential identify with remains poorly understood. Here, we investigated whether microRNA profile could be...