A5090528795- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Extracellular vesicles in disease
- RNA Research and Splicing
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Amoebic Infections and Treatments
- High Altitude and Hypoxia
- Synthesis of Tetrazole Derivatives
- Nanomaterials for catalytic reactions
- Molecular Biology Techniques and Applications
- Cancer Mechanisms and Therapy
- Cellular Mechanics and Interactions
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- Parasitic Infections and Diagnostics
- Adipose Tissue and Metabolism
- Histone Deacetylase Inhibitors Research
- Genomics and Chromatin Dynamics
Universidad Autónoma de la Ciudad de México
2018-2024
Centro de Epilepsia y Neurocirugía Funcional
2024
Center for Research and Advanced Studies of the National Polytechnic Institute
2021-2022
Instituto Politécnico Nacional
2021-2022
Centro de Investigación en Materiales Avanzados
2021-2022
Tumors have high requirements in terms of nutrients and oxygen. Angiogenesis is the classical mechanism for vessel formation. Tumoral vascularization has function nourishing cancer cells to support tumor growth. Vasculogenic mimicry, a novel intratumoral microcirculation system, alludes ability organize three-dimensional (3D) channel-like architectures. It also supplies tumors with Both mechanisms operate coordinated way; however, their functions breast stem-like regulation by microRNAs...
Abstract Chemotherapy activates a novel cytoplasmic DNA damage response resulting in Golgi apparatus fragmentation and cancer cell survival. This mechanism is regulated by phosphoprotein-3 (GOLPH3)/Myo18A/F-actin axis. Analyzing the functions of miR-3135b, small non-coding RNA with unknown functions, we found that its forced overexpression attenuates induced chemotherapeutic drugs colorectal (CRC) cells. First, miR-3135b downregulated CRC lines clinical tumors. Bioinformatic predictions...
Vasculogenic mimicry (VM) is a novel cancer hallmark in which malignant cells develop matrix-associated 3D tubular networks with lumen under hypoxia to supply nutrients needed for tumor growth. Recent studies showed that microRNAs (miRNAs) may have role VM regulation. In this study, we examined the relevance of hypoxia-regulated miRNAs (hypoxamiRs) early stages formation. Data after 48 h and 12 incubation on matrigel SKOV3 ovarian undergo formation intercellular connections referred...
HOX transcript antisense RNA (HOTAIR) is an oncogenic long non-coding frequently overexpressed in cancer. HOTAIR can enhance the malignant behavior of tumors by sponging microRNAs with tumor suppressor functions. Vasculogenic mimicry a hypoxia-activated process which cells form three-dimensional (3D) channel-like networks, resembling endothelial blood vessels, to obtain nutrients. However, role vasculogenic and underlying mechanisms are unknown human cancers. In current study, we...
The 3D organotypic cultures, which depend on the growth of cells over extracellular matrix (ECM) used as a scaffold, can better mimic several characteristics solid cancers that influence tumor biology and response to drug therapies. Most our current knowledge cancer is derived from studies in 2D lack ECM-mediated microenvironment. Moreover, role miRNAs critical for fine-tuning gene expression poorly understood cultures. aim this study was compare miRNA profiles breast grown conditions. On an...
MicroRNAs (miRNAs) are small non-coding RNAs that function as negative regulators of gene expression. Recent evidences suggested host cells miRNAs involved in the progression infectious diseases, but its role amoebiasis remains largely unknown. Here, we reported an unexplored for human epithelial colon during apoptosis induced by Entamoeba histolytica. We demonstrated first time SW-480 change their profile response to parasite exposure. Our data showed virulent E. histolytica trophozoites...
Vasculogenic mimicry (VM) is characterized by formation of three-dimensional (3D) channels-like structures tumor cells, supplying the nutrients needed for growth. VM stimulated hypoxic microenvironment, and it has been associated with increased metastasis clinical poor outcome in cancer patients. cAMP responsive element (CRE)-binding protein 5 (CREB5) a hypoxia-activated transcription factor involved tumorigenesis. However, CREB5 functions if its regulated microRNAs remains unknown breast...
Cancer patients who better benefit from neoadjuvant chemotherapy (NeoCh) are those achieve a successful pathological complete response (pCR) represented by the absence of residual disease. Unfortunately, no highly sensitive and specific tumor biomarkers for predicting clinical to NeoCh have yet been defined. The aim present study was ascertain whether miR‑145‑5p could discriminate between pCR no‑pCR in triple‑negative breast cancer that received cisplatin/doxorubicin‑based treatment....
Organotypic three-dimensional (3D) cell cultures more accurately mimic the characteristics of solid tumors in vivo comparison with traditional two-dimensional (2D) monolayer models. Currently, studies on regulation long non-coding RNAs (lncRNAs) have not been explored breast cancer cells cultured 3D microenvironments. In present research, we studied expression and potential roles lncRNAs estrogen receptor-positive luminal B subtype BT-474 grown over extracellular matrix proteins-enriched...
Nanotechnology is focused on the development and application of novel nanomaterials with particular physicochemical properties. Palladium nanoparticles (PdNPs) have been used as antimicrobials, antifungals, photochemicals for catalytic activity in dye reduction. In present investigation, we developed characterized PdNPs a carrier quercetin initiated study its effects colorectal cancer cells. were first functionalized polyvinylpyrrolidone (PVP) then coupled to (PdNPs-PVP-Q). Our results...
While epidemiological evidence has long linked obesity with an increased risk of breast cancer, the intricate interactions between adipocytes and cancer cells within tumor microenvironment remain largely uncharted territory. The use organotypic three-dimensional (3D) cell cultures that more accurately mimic spatial architecture tumors represents innovative approach to this complex issue. In present study, we investigated effects on proteome Hs578t cultured in a 3D microenvironment. Using...