A5056311564- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immune cells in cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer, Stress, Anesthesia, and Immune Response
- CAR-T cell therapy research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Angiogenesis and VEGF in Cancer
- Lung Cancer Treatments and Mutations
- Plant chemical constituents analysis
- Immune Response and Inflammation
- Pleural and Pulmonary Diseases
- Synthesis and Biological Activity
- Cytokine Signaling Pathways and Interactions
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
Instituto Nacional de Enfermedades Respiratorias
2015-2025
The University of Texas MD Anderson Cancer Center
2012-2020
National Commission for the Knowledge and Use of Biodiversity
2011
Center for Research and Advanced Studies of the National Polytechnic Institute
2007
Instituto Nacional de Cancerología
2007
Hospital Militar de Santiago
2006
Abstract Purpose: 90Y-FF-21101 is an Yttrium-90–conjugated, chimeric mAb that highly specific for binding to human placental (P)-cadherin, a cell-to-cell adhesion molecule overexpressed and associated with cancer invasion metastatic dissemination in many types. We report the clinical activity of first-in-human phase I study patients advanced solid tumors. Patients Methods: The safety efficacy were evaluated 3+3 dose-escalation tumors (n = 15) over dose range 5–25 mCi/m2. Dosimetry using...
Immunogenic cell death is a modality that stimulates the immune system to combat cancer cells. IMMUNEPOTENT CRP (ICRP) mixture of substances low molecular weight obtained from bovine spleens exhibits in vitro cytotoxic activity on different tumor lines and modulates response vivo. The aim present study was determine whether effect ICRP its combination with oxaliplatin (OXP) murine melanoma B16F10 cells due immunogenic death. assay performed using flow cytometry detect Annexin V propidium...
Cytokines, key contributors to tumorigenesis, are mediators between inflammatory immune or nonimmune and cancer cells. Here, IL-6 production by tumor cells was assessed in a cohort of patients with lung adenocarcinoma treated conventional therapy. levels neutrophil–lymphocyte ratio (NLR) systemic immune-inflammation index (SII) markers were evaluated. Changes pro- anti-inflammatory cytokines, HMGB1 concentration, CD4+ CD8+ T-lymphocyte populations their subpopulations investigated....
Lung cancer is the leading cause of death worldwide and non-small cell lung carcinoma (NSCLC) most common type carcinomas. In adenocarcinomas, frequent histologic NSCLC, dendritic cells (DCs) are localized in close contact with tumor cells, tumor-infiltrating lymphocytes (TILs) observed peritumoral zones. no studies investigating density intratumoral DCs their impact on TILs have been performed. addition, role alarmin high-mobility group box1 (HMGB1) recruitment has not analyzed. present...
Lung cancer is the leading cause of death worldwide. Adenocarcinoma, most commonly diagnosed histologic type lung cancer, associated with smoking. Cigarette smoke promotes inflammation on airways, which might be mediated by Th17 cells. This inflammatory environment may contribute to tumor development. In contrast, some reports indicate that tumors induce immunosuppressive Treg cells dampen immune reactivity, supporting growth and progression. Thus, we aimed analyze whether chronic or...