A5034899428- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Oral Health Pathology and Treatment
- Veterinary Oncology Research
- Virus-based gene therapy research
- Oral microbiology and periodontitis research
- Nanoparticles: synthesis and applications
- Acute Lymphoblastic Leukemia research
- Fungal Infections and Studies
- Neutropenia and Cancer Infections
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Graphene and Nanomaterials Applications
- Heavy Metal Exposure and Toxicity
- Protein purification and stability
- Histone Deacetylase Inhibitors Research
- Cancer Research and Treatments
- Inflammatory mediators and NSAID effects
- Acute Myeloid Leukemia Research
- Extracellular vesicles in disease
- Complement system in diseases
- Antifungal resistance and susceptibility
Universidad del Valle de México
2019-2021
Universidad Autónoma de Nuevo León
2013-2018
Immunogenic cell death is a modality that stimulates the immune system to combat cancer cells. IMMUNEPOTENT CRP (ICRP) mixture of substances low molecular weight obtained from bovine spleens exhibits in vitro cytotoxic activity on different tumor lines and modulates response vivo. The aim present study was determine whether effect ICRP its combination with oxaliplatin (OXP) murine melanoma B16F10 cells due immunogenic death. assay performed using flow cytometry detect Annexin V propidium...
Context: Exosomes secreted by tumor cells are a good source of cellular components that stimulate the immune response, such as alarmins (mRNA, tetraspanins (CD9, CD63, CD81), heat-shock proteins, major histocompatibility complex class I molecules) and tumor-associated antigens. These properties permit to pulsed dendritic in immunotherapy for many cancers types. The aim this study was demonstrate use exosomes derived from canine transmissible venereal (CTVT) an antigen its administration dogs...
Chemotherapy treatments induce a number of side effects, such as leukopenia neutropenia, peripheral erythropenia, and thrombocytopenia, affecting the quality life for cancer patients. 5-Fluorouracil (5-FU) is wieldy used myeloablative model in mice. The bovine dialyzable leukocyte extract (bDLE) or IMMUNEPOTENT CRP® (ICRP) an immunomodulatory compound that has antioxidants anti-inflammatory effects. In order to investigate chemoprotection effect ICRP on bone marrow cells 5-FU treated mice,...
The forkhead box P3 (Foxp3) transcription factor is one of the most studied markers used to identify CD4+CD25+ regulatory T cells (Tregs), and has been identified as a key regulator in development function Tregs. Foxp3 expression reported variety solid human tumors, including melanoma. aims present study were analyze B16F10 melanoma vitro, determine whether this was affected during tumor growth murine model correlate with CD25 expression, interleukin (IL)-2 production weight. analyzed...
Forkhead box p3 (Foxp3) expression was believed to be specific for T-regulatory cells but has recently been described in non-hematopoietic from different tissue origins and tumor both epithelial non-epithelial tissues. The aim of this study elucidate the role Foxp3 murine melanoma. B16F10 cell line silenced with small interference plasmid transfection established named B16F10.1. These had lower levels mRNA (quantitative real-time reverse transcription-polymerase chain reaction [0.235-fold]),...
Trichosporon asahii is an opportunistic yeastlike fungus commonly associated with systemic infections in immunocompromised patients. Neutropenia recognized as the main risk factor by T. asahii; however, little known about cytokine response during trichosporonosis. Here, we evaluated and local production histological damage immunocompetent mice infection asahii. We found a significant increased presence of G-CSF, TNF-α, IFN-γ, IL-6 sera samples. High levels G-CSF were organs (kidney, liver...
Glioblastoma multiforme is a malignant neoplasm of the brain with poor prognosis. The first-line drug against glioblastoma alkylating agent temozolamide (TMZ); unfortunately, treatment resistance and tumor re-incidence are common. In some cases, immunogenic cell death (ICD) inducers can decrease recurrence by stimulating an antitumor specific immune response. Not all ICD inducers, however, suitable for glioma patients because low permeability blood-brain barrier (BBB). Panobinostat (PAN),...
Colloidal silver (AgC) is currently used by humans and it can be internalized through inhalation, injection, ingestion, dermal contact. However, there limited information about immunological activity; more investigations using colloidal are needed. In the present study, effects of AgC (17.5 ng/mL) on parameters (proliferation immunophenotyping) human peripheral blood mononuclear cells (PBMC) macrophages (phagocytosis) cytotoxicity leukemia lymphoma cancer cell lines (1.75 to 17.5 were...
IMMUNEPOTENT CRP is a dialyzable leukocyte extract obtained from bovine spleen with immunomodulatory and antitumour properties; therefore, when administrated as an adjuvant therapy for cancer patients, it has increased their survival quality of life. The bioavailability any orally administered compound can be reduced due to gastrointestinal enzymes. In this study, we evaluated if resistant the treatment different enzymes (proteases, nucleases, polysaccharide-degrading or lipase), using...
Differentiation induction therapy is an attractive approach in leukemia treatment due to the fact that blast crisis stage, leukemic cells lose their differentiation capacity. Therefore, it has been proposed as a therapeutic strategy induce terminal of into specific lineage, leading prevention high proliferation rates. The aim present study was demonstrate potential cell and death induced by bovine dialyzable leukocyte extract (bDLE) K562 line. For this purpose MOLT‑3 human lines primary...
A controlled, parallel, randomized and comparative trial was carried out to evaluate the anti-inflammatory efficacy of IMMUNEPOTENT CRP versus ibuprofen in patients after third-molar surgery over seven days. The evaluated using method Amin Laskin, analysis cytokine production (IL-2, IL-4, IL-6, IL-10, TNF-α, INF-γ) saliva done by flow cytometry. swelling process significant (p < 0.05) treatments with or controlled this properly; no difference between groups found 0.05). Both were shown...
The aim of the present study was to evaluate therapeutic potential autologous DCs loaded with whole tumor cell lysate CTVT generated under a simplified and rapid procedure in vitro production process, vulvar submucosal model dogs.We intravulvar dogs. A antigen prepared according method 1-butanol after administered complete Freund's adjuvant via subcutaneous female healthy dogs challenge cells corroborate immunogenicity. Short-time dendritic pulsed whole-lysate performed, analyzed by...
Background: Immunotherapy involving dendritic cells (DC) has been used to treat cancer with satisfactory results. The generation of mature derived from monocytes, however, is expensive because the use cytokines. Objective: To reduce DC therapy costs, it important evaluate lower-cost materials capable inducing cell maturation; for this purpose, we synthetized chitosan nanoparticles. Methods: Chitosan nanoparticles were by ionic gelation and characterized using dynamic light scattering, laser...
Abstract Background The oral microenvironment provides the conditions for establishment of microorganisms not usually considered residents normal microbiota. Sexually transmitted such as Chlamydia trachomatis can adhere to any mucosal surface and ascend reach appropriate locations survive develop symptomatic infections. Materials methods To determine presence C. , direct immunofluorescence this microorganism was carried out in 76 randomly selected patients attending a periodontal clinic...