A5051859402- Ocular Oncology and Treatments
- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- Drug Transport and Resistance Mechanisms
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- HIV/AIDS drug development and treatment
- Epilepsy research and treatment
- Glioma Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Cancer Genomics and Diagnostics
- Analytical Methods in Pharmaceuticals
- Colorectal Cancer Treatments and Studies
- Receptor Mechanisms and Signaling
- Cardiac electrophysiology and arrhythmias
- Pharmaceutical studies and practices
- Neuropeptides and Animal Physiology
- Anesthesia and Sedative Agents
- Ocular Infections and Treatments
- Diabetes Management and Research
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Assays
- Pneumocystis jirovecii pneumonia detection and treatment
- Lung Cancer Research Studies
- Neurotransmitter Receptor Influence on Behavior
University of Buenos Aires
2012-2021
Fundación para la Investigación, Docencia y Prevención del Cáncer
2015-2021
Favaloro Foundation
2018
Instituto de Química y Fisicoquímica Biológicas
2012
Garrahan Hospital
2006
Consejo Nacional de Investigaciones Científicas y Técnicas
1993
Purpose.: To characterize melphalan pharmacokinetics after superselective ophthalmic artery infusion (SSOAI) in animals and children with retinoblastoma. Methods.: Vitreous plasma samples of five Landrace pigs were obtained over a 4-hour period SSOAI (7 mg). Melphalan cytotoxicity was evaluated retinoblastoma cell lines without topotecan. Plasma from 17 patients 3 to 6 mg one (n = 14) or two eyes 3). Correlation between age, dosage, systemic toxicity studied patients. Results.: In animals,...
To determine the extent and mechanism by which topotecan, a candidate agent for treatment of retinoblastoma, gains access to vitreous when administered periocular injection or intravenous infusion.In vivo experiments were conducted in albino rabbits received 1 mg topotecan (POI group; n = 30) as 30-minute infusion (IV 16). Plasma vitreal concentrations analyzed during 10 hours after administration. A population pharmacokinetic model was fit data. Additionally, injections performed postmortem...
purpose. To identify the maximum tolerated dose and dose-limiting toxicity of periocular topotecan in patients with relapsed or resistant intraocular retinoblastoma who are facing imminent enucleation. methods. For this phase I study, a starting 0.5 mg administered through 25-gauge needle was given intrapatient escalation at rate mg/cycle according to toxicity, up 2 mg. Two courses separated by weeks were scheduled. Plasma levels measured high-performance liquid chromatography available...
Purpose. Intravenous or periocular topotecan has been proposed as new treatment modality for patients with advanced intraocular retinoblastoma, but systemic lactone exposure induced by both approaches may cause toxicity. The purpose of this study was to develop a topotecan-loaded ocular delivery system minimize and achieve selective transscleral penetration. Methods. Biocompatible polymer implants containing low (0.3 mg) high (2.3 load were manufactured characterized in vitro. Adrenaline...
Aim: To assess the involvement of ABCG2 in pharmacokinetics efavirenz blood–brain barrier (BBB) and investigate a nanotechnology strategy to overcome its overexpression under model chronic oral administration. Materials & methods A (EFV) administration was established male Sprague–Dawley rats treated with daily dose over 5 days. Then, different treatments were conducted drug concentrations plasma brain measured. Results: Chronic treatment EFV led BBB that reverted after brief washout period....
To characterize the vitreous and plasma pharmacokinetics of topotecan after ophthalmic artery infusion (OAI) subsequent to superselective catheterization compare it with periocular injection (POI).The 4 pigs was catheterized 1 mg infused over a period 30 minutes. The contralateral eye subsequently used for administering by POI. Serial specimens were obtained microdialysis samples collected assayed total lactone topotecan.Maximum concentration in (median, range) significantly higher OAI...
<b><i>Objective:</i></b> Latin American countries are heterogeneous in terms of lung cancer incidence and exposure to potential carcinogens. We evaluated the frequency clinical characteristics <i>ALK</i> rearrangements (<i>ALKr</i>) America. <b><i>Methods:</i></b> A total 5,130 patients from 10 were screened for inclusion. <i>ALKr</i> detection was performed by fluorescence situ hybridization (FISH),...
The aim of this work is to: (1) assess therapeutic drug monitoring indinavir (IDV) during clinical routine practice in HIV-infected children, whose antiretroviral treatment includes IDV boosted with ritonavir (RTV), and (2) describe a possible relationship between pharmacokinetics MDR1 genotypes. In 21 ambulatory pediatric patients receiving plus RTV, plasma levels <i>MDR1</i> genotypes on exon 26 (C3435T) were determined. Nine the initially 250 mg/m<sup>2</sup>...
The evidence available in the pediatric population is limited for making clinical decisions regarding optimization of tacrolimus (TAC) pharmacotherapy. objective this study was to estimate frequency CYP3A5 genetic polymorphisms and their relationship with requirements population. This a longitudinal cohort two-year follow-up 77 patients under 18 years old who underwent liver transplant during period 2009-2012 at J.P. Garrahan Pediatric Hospital. Tacrolimus levels from day five up two after...