A5037022046- Respiratory viral infections research
- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Pharmaceutical studies and practices
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Climate Change and Health Impacts
- Paraquat toxicity studies and treatments
- Global Public Health Policies and Epidemiology
- Pharmacological Effects and Toxicity Studies
- Cystic Fibrosis Research Advances
- Renal Transplantation Outcomes and Treatments
- Global Health Care Issues
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Congenital Heart Disease Studies
- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Tracheal and airway disorders
- Child and Adolescent Health
- Poisoning and overdose treatments
- Neonatal and Maternal Infections
Universidad de Antioquia
2015-2025
University of Warwick
2024
University of Oxford
2023-2024
Pontificia Universidad Católica de Chile
2023
Institute for Health Metrics and Evaluation
2022-2023
University of Electronic Science and Technology of China
2023
Institute of Cardiology
2023
University of Washington
2022
National Health and Medical Research Council
2022
Amazon (United States)
2022
Several clinical practice guidelines exist for the management of respiratory syncytial virus (RSV) infection, but use and overuse medications medical tests with insufficient evidence effectiveness remains substantial. This study aimed to evaluate costs associated bronchiolitis hospitalizations caused by RSV infection among infants aged < 2 years in Colombia. was a prevalence-based cost-of-illness multicentric performed from societal perspective during 2016–2017. A case defined as...
Abstract Introduction Respiratory syncytial virus infection is the leading cause of lower respiratory globally. Recently, nirsevimab has been approved to prevent (RSV) infection. This study explores economically justifiable price for preventing RSV in Colombia's children under 1 year age. Materials and Methods A static model was developed using decision tree microsimulation estimate quality‐adjusted costs life years two interventions: a single intramuscular dose versus not applying...
Asthma imposes a critical economic burden on health systems, especially with the incorporation of new drugs. Recently, mepolizumab has been approved to prevent exacerbations in patients eosinophilic asthma, however their high cost constitutes barrier for use, middle- and low-income countries. This study aimed estimate economically justifiable price preventing severe asthma Colombia. A model was developed using microsimulation quality-adjusted costs life years two interventions: versus not...
<ns3:p>Introduction Asthma imposes a substantial economic burden on health systems. By understanding the and its projections, public officials governments can design more effective asthma management prevention strategies. This study aimed to estimate global of asthma. Methods We projected future year DALYs lost based annual rate change 1990-2021 from Institute for Health Metrics Evaluation’s (IHME) Global Burden Diseases (GBD) study<ns3:bold>.</ns3:bold> applied concept value statistical...
Mepolizumab, an IL-5 receptor antagonist, is a targeted therapy approved for treating severe eosinophilic persistent asthma. While it offers significant clinical benefits in reducing exacerbations and improving quality of life, its high cost raises concerns about affordability overall value resource-constrained settings. This study evaluates the cost-effectiveness adding mepolizumab to standard care (SoC) compared SoC alone adolescents adults with severe, uncontrolled asthma Colombia. We...
Background Previous studies have reported a reduced tacrolimus dose-adjusted exposure in individuals expressing the CYP3A5*1 allele (rs 776746). However, information regarding Colombian liver transplantation patients is scarce. This study aimed to investigate influence of CYP3A5 polymorphism on (TAC) pharmacokinetics transplant patients. Methods was prospective, single-center, open-label, pharmacogenetic stable adult recipients followed up between 2020 and 2022. To evaluate longitudinal...
Paraquat (PQ) poisoning is a public health problem in many regions of Colombia. This study aimed to estimate the burden PQ Department Antioquia, Disability-adjusted life year (DALYs) were calculated as sum years lost (YLL) and lived with disability (YLD) due paraquat Antioquia; bootstrapped method 1000 iterations was used each statistical parameter using package DALY calculator R. For this instance, annual incidence obtained from reported surveillance data according regional Government. From...
Objectives: Differential pricing, based on countries’ purchasing power, is recommended by the World Health Organization to secure affordable medicines. However, in developing countries innovative drugs often have similar or even higher prices than high-income countries. We evaluated potential implications of trastuzumab global pricing policies terms cost-effectiveness (CE), coverage, and accessibility for patients with breast cancer Latin America (LA). Methods: A Markov model was designed...
Trastuzumab (Herceptin), a recombinant, humanized, monoclonal antibody targeting HER2 is well established as an effective treatment for HER2-positive breast cancer. Evidence from developed countries showed that trastuzumab was cost-effective; but there are few evidences in developing countries. This study assesses the cost-effectiveness of adjuvant Colombia.A Markov health-state transition model built to estimate clinical and economic outcomes cancer with or without 12 months chemotherapy...
Abstract Introduction Increasing evidence has demonstrated the effectiveness and safety of vitamin D supplementation to prevent acute respiratory infections in children. More economic evaluations incorporating new pediatric population are needed know efficiency this treatment. This study aimed determine cost-utility patients. Methods A decision tree model was used estimate cost quality-adjusted life-years (QALYs) healthy school children between 1 16 years. Multiple sensitivity analyses were...
BACKGROUND: The aim of these clinical standards is to aid the diagnosis and management asthma in low-resource settings low- middle-income countries (LMICs). METHODS: A panel 52 experts field LMICs participated a two-stage Delphi process establish reach consensus on standards. RESULTS: Eighteen were defined: Standard 1, Every individual with symptoms signs compatible should undergo assessment; 2, In individuals (>6 years) assessment supportive asthma, hand-held spirometry measurement be...
Recent evidence indicates that Maternal Supplementation with Long-Chain n-3 Fatty Acids During Pregnancy Substantially Mitigates Offspring's Asthma. Adding information regarding its cost-utility will undoubtedly allow adoption, or not, in clinical practice guidelines. This research aimed to determine the of LCPUFA supplementation third trimester pregnancy reduce risk wheezing and asthma infants Colombia.
Abstract Introduction Asthma imposes a crucial economic burden on health systems, especially with the incorporation of new drugs. Recently, mepolizumab has been approved to prevent exacerbations in patients eosinophilic asthma. This study explores economically justifiable price for preventing children severe Materials and Methods A model was developed using microsimulation estimate quality‐adjusted costs life years two interventions: versus not applying standard treatment without...
In patients with uncontrolled asthma, despite management high doses of inhaled corticosteroids, the additional use omalizumab and tiotropium is recommended. Omalizumab an expensive medication doubts arise as to whether benefit this drug outweighs expense drug. The purpose study was assess cost-effectiveness versus add-on therapies ICS + LABA for allergic asthma.A probabilistic Markov model created estimate cost quality-adjusted life years (QALYs) asthma in Colombia. Total costs QALYs three...
High-flow nasal cannula (HFNC) oxygen is a non-invasive ventilation system that was introduced as an alternative to CPAP (continuous positive airway pressure), with marked increase in its use pediatric care settings. This study aimed evaluate the cost-effectiveness of early HFNC compared by infant bronchiolitis emergency setting.A decision tree model used estimate (control strategy) setting. Cost data were obtained from retrospective on tertiary centers Rionegro, Colombia, while utilities...
Dupilumab is an effective and safe medicine for the management of severe asthma. Due to its high cost, concerns are generated regarding cost-effectiveness. This study aimed estimate cost-utility dupilumab plus standard care (SoC) versus SoC alone in children between 6 11 years old with asthma eosinophilic phenotype.A Markov-type model was developed costs health outcomes a simulated cohort pediatric patients persistent treated over 6-year period. To determine robustness deterministic...
Abstract Introduction Fractional exhaled nitric oxide is a simple, non-invasive measurement of airway inflammation with minimal discomfort to the patient and results available within few minutes. This study aimed evaluate cost-effectiveness asthma management using fractional monitoring in patients between 4 18 years age. Methods A Markov model was used estimate cost-utility versus without (standard therapy) Cost data were obtained from retrospective on tertiary center, Medellin, Colombia,...
Benralizumab, amonoclonal antibody for human interleukin-5, has been associated with adecrease in asthma exacerbations. The introduction of this drug raises concerns about the economic impact scenarios constraints. This study aimed to estimate cost-utility benralizumab plus standard care (SoC) vs. SoC alone adults severe uncontrolled evidence eosinophilic phenotype.We constructed aMarkov model three health states (asthma on and SOC, SOC alone, death) from ahealthcare system perspective over...