Abstract Introduction Respiratory syncytial virus infection is the leading cause of lower respiratory globally. Recently, nirsevimab has been approved to prevent (RSV) infection. This study explores economically justifiable price for preventing RSV in Colombia's children under 1 year age. Materials and Methods A static model was developed using decision tree microsimulation estimate quality‐adjusted costs life years two interventions: a single intramuscular dose versus not applying...

Mepolizumab, an IL-5 receptor antagonist, is a targeted therapy approved for treating severe eosinophilic persistent asthma. While it offers significant clinical benefits in reducing exacerbations and improving quality of life, its high cost raises concerns about affordability overall value resource-constrained settings. This study evaluates the cost-effectiveness adding mepolizumab to standard care (SoC) compared SoC alone adolescents adults with severe, uncontrolled asthma Colombia. We...

SUMMARY This study aimed to determine which meteorological conditions are associated with respiratory syncytial virus (RSV) isolates in a population of children hospitalized acute lower infection (ALRI) Bogota, Colombia. In an analytical cross-sectional study, links were examined between the number monthly RSV infections and average climatic variation (temperature, relative humidity, rainfall, wind speed, solar radiation) 1 January 2010 30 April 2011 aged <3 years ALRI caused by RSV. Out...

High-flow nasal cannula (HFNC) oxygen is a non-invasive ventilation system that was introduced as an alternative to CPAP (continuous positive airway pressure), with marked increase in its use pediatric care settings. This study aimed evaluate the cost-effectiveness of early HFNC compared by infant bronchiolitis emergency setting.A decision tree model used estimate (control strategy) setting. Cost data were obtained from retrospective on tertiary centers Rionegro, Colombia, while utilities...

Abstract Introduction Fractional exhaled nitric oxide is a simple, non-invasive measurement of airway inflammation with minimal discomfort to the patient and results available within few minutes. This study aimed evaluate cost-effectiveness asthma management using fractional monitoring in patients between 4 18 years age. Methods A Markov model was used estimate cost-utility versus without (standard therapy) Cost data were obtained from retrospective on tertiary center, Medellin, Colombia,...

Although predictors of severe viral acute lower respiratory infections (ALRIs) in children have been reported, there few research studies performed low- and middle-income countries (LMIC). The aim the present study was to determine disease severity a population Colombian <5 years age with ALRI. In prospective cohort study, we determined independent ALRI hospitalized under 5 old during 1-year period. We included both underlying conditions infecting viruses as predictor variables disease....

Abstract Introduction Although evidence supports the use of intravenous magnesium sulfate (MS) in asthma exacerbations, MS continues to be considered a second‐line drug for managing pediatric exacerbations. This study aimed evaluate cost‐utility Methods We used decision tree model estimate compared treatment without (control group) children with Cost data were obtained from retrospective tertiary centers Rionegro, Colombia, while utilities collected literature. Probabilistic sensitivity...

The aim of the present study is to gain insight into identification region-specific factors associated with poor outcomes in children under 5 years age confirmed respiratory syncytial virus acute lower infection (RSV-ALRI) living Colombia, a middle-income country, based on National Public Health Surveillance System country.An analytical cross-sectional was conducted using epidemiological data from records morbidity and mortality infections as registered surveillance system report Institute...

Introduction: Despite the high probability of a heavy burden for parents and/or caregivers children with asthma, instruments intended to measure it have not been validated in context asthma. Moreover, factors associated this are unknown.Objective: To begin validation scale parents/caregivers asthmatic children, and determine burden.Materials methods: We performed an analytical cross-sectional study. At outpatient section Clinic Pediatric Pulmonology Hospital Universitario Clinica San Rafael,...

Recently, in an attempt to reduce variability clinical practice and produce better results for patients, several guidelines (CPGs) the appropriate diagnosis management of bronchiolitis infants have been developed. However, quality available CPGs has not yet systematically evaluated. The aim this study was assess acute viral CPGs.We performed a systematic exhaustive search on published from 2000 2014. Three independent appraisers assessed using Appraisal Guidelines Research Evaluation (AGREE)...

Length of hospital stay and readmissions are outcome measures that have been largely overlooked in many studies evaluated the clinical evolution pediatric patients with bronchopulmonary dysplasia (BPD). The aim present study was to identify predictors prolonged hospitalizations or for acute lower respiratory infections (ALRIs) infants BPD. In a prospective cohort study, we determined independent ALRIs during first 2 years life population BPD living Bogota, Colombia. Of total 138 included 83...

Background High-flow nasal cannula is a non-invasive ventilation system that was introduced as an alternative to continuous positive airway pressure), with marked increase in its use pediatric care settings. However, the expected budget impact of this intervention has not been explicitly estimated. This study aimed evaluate high-flow for acute bronchiolitis Colombia.Methods A analysis performed potential financial deriving from during 2020. The considered 5-year time horizon and Colombian...

Abstract We need a better risk stratification system for the increasing number of survivors extreme prematurity suffering most severe forms bronchopulmonary dysplasia (BPD). However, there is still paucity studies providing scientific evidence to guide future updates BPD severity definitions. Our goal was validate new predictive model that incorporates respiratory assessments beyond 36 weeks postmenstrual age (PMA). hypothesized this approach improves assessment, particularly in extremely...

Abstract Background Pharmacological treatment for bronchiolitis is primarily supportive because bronchodilators, steroids, and antibiotics, show little benefit. Clinical studies have suggested that nebulized 3% hypertonic solution useful infants with bronchiolitis. This study aims to evaluate the cost-effectiveness of HS inhalations in infant a tropical country. Methods Decision tree analysis was used calculate expected costs QALYs. All cost use resources were collected directly from medical...

Over the last decades, dietary habits in developing countries have been characterized by low intake of fruits and vegetables high consumption sweetened drinks. Most evidence linking carbohydrate asthma comes from children over 6 years age. The aim this study was to examine association between macronutrient severity exacerbations aged 2-6 years.We performed a cross-sectional that included all hospitalized due an exacerbation. Dietary data were collected using food frequency questionnaire...

Guidelines for asthma management recommend, before establishing additional therapeutic behaviors, to confirm correct use and adequate adherence treatment. Evidence exists on the of fractional exhaled nitric oxide (FeNO) values monitoring in adults. It is important establish whether there a correlation between FeNO children. This study aims provide new knowledge about relationship asthmatic children.Analytical cross-sectional including patients 5-18 years age, attending follow-up at Hospital...

<b>Objectives:</b> The aim of the present study is to gain insight into identification region-specific factors associated with poor outcomes in children under 5 years age confirmed respiratory syncytial virus acute lower infection (RSV-ALRI) living Colombia, based on National Public Health Surveillance System country. <b>Methods:</b> An analytical cross-sectional was conducted using epidemiological data from records morbidity and mortality infections as registered surveillance system report...

Abstract Background Pharmacological treatment for bronchiolitis is primarily supportive because bronchodilators, steroids, and antibiotics, show little benefit. Clinical studies have suggested that nebulized 3% hypertonic solution useful infants with bronchiolitis. This study aims to evaluate the cost-effectiveness of HS inhalations in infant a tropical country Methods Decision tree analysis was used calculate expected costs QALYs. All cost use resources were collected directly from medical...

Abstract Background: High-flow nasal cannula (HFNC) oxygen is a non-invasive ventilation system that was introduced as an alternative to CPAP (continuous positive airway pressure), with marked increase in its use pediatric care settings .This study aimed evaluate the cost-effectiveness of early HFNC compared by infant bronchiolitis emergency setting. Methods : A decision tree model used estimate (control strategy) Cost data were obtained from retrospective on tertiary centers Rionegro,...

Abstract Background Pharmacological treatment for bronchiolitis is primarily supportive because bronchodilators, steroids, and antibiotics, show little benefit. Clinical studies have suggested that nebulized 3% hypertonic solution useful infants with bronchiolitis. This study aims to evaluate the cost-effectiveness of HS inhalations in infant a tropical country Methods Decision tree analysis was used calculate expected costs QALYs. All cost use resources were collected directly from medical...

Introduction . Respiratory syncytial virus infection is the leading cause of lower respiratory globally. Recently, nirsevimab has been approved to prevent RSV infection. This study explores economically justifiable price for preventing in Colombia’s children under one year age. Materials and methods A static model was developed using decision tree microsimulation estimate quality-adjusted costs life years two interventions: a single intramuscular dose versus not applying nirsevimab. analysis...

Fractional exhaled nitric oxide (FeNO) testing is a simple, noninvasive approach to assessing airway inflammation with minimal discomfort that provides results within few minutes. For policy makers, the economic impact of this technology main concern, especially in developing countries. We evaluated budget asthma management using FeNO monitoring patients aged between 4 and 18 years Colombia.A analysis was performed evaluate potential cost monitoring. The based on 5-year time horizon from...

<b>Background:</b> Recently, in an attempt to reduce variability clinical practice and produce better results for patients, several guidelines (CPGs) the appropriate diagnosis management of bronchiolitis have been developed. However, quality available CPGs has not yet systematically evaluated. <b>Objective:</b> The aim this study was assess acute viral CPGs. <b>Methods:</b> We performed a systematic exhaustive search on published from 2000 2014. Three independent appraisers assessed using...