A5017491900- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Respiratory Support and Mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Hemodynamic Monitoring and Therapy
- Atomic and Subatomic Physics Research
- Adolescent and Pediatric Healthcare
- Viral gastroenteritis research and epidemiology
- Cardiac, Anesthesia and Surgical Outcomes
- Transplantation: Methods and Outcomes
- Birth, Development, and Health
- Cardiovascular Health and Disease Prevention
- Infant Health and Development
- Functional Brain Connectivity Studies
- Renal function and acid-base balance
- Mechanical Circulatory Support Devices
- Non-Invasive Vital Sign Monitoring
- Family and Patient Care in Intensive Care Units
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
Children's National
2013-2022
George Washington University
2015-2022
George Washington University Hospital
2018
Brain structural changes in premature infants appear before term age. Functional differences between and healthy fetuses during this period have yet to be explored. Here, we examined brain connectivity using resting state functional MRI 25 very (VPT; gestational age at birth <32 weeks) with structurally normal MRIs. Resting data were evaluated seed-based correlation analysis network-based statistics 23 regions of interest (ROIs) per hemisphere. strength, the Pearson blood oxygenation level...
Necrotizing enterocolitis (NEC) is a devastating gastrointestinal emergency. The purpose of this study to determine if functional single nucleotide polymorphisms (SNPs) in immune-modulating genes pre-dispose infants NEC. After Institutional Review Board approval and parental consent, buccal swabs were collected for DNA extraction. TaqMan allelic discrimination assays BglII endonuclease digestion used genotype specific inflammatory cytokines TRIM21. Statistical analysis was completed using...
To monitor altered mesenteric tissue oxygen saturation (StO2) before and after blood transfusion.We placed a 4-wavelength NIRS sensor (FORE-SIGHT, CASMED, Branford, CT USA) on the right lower abdominal quadrant prior to transfusion measured StO2 for up 48 hours post transfusion. Pulse oximetry (SpO2) data was collected simultaneously, with fractional extraction (FTOE) [SpO2-StO2] difference calculated normalize hypoxic episodes. All combined averaged in 30 minute windows events before,...
Background Necrotizing enterocolitis (NEC) is a complication of prematurity with high mortality rate. Currently, there are no reliable biomarkers capable identifying infants at risk for developing NEC. We sought to determine the autonomic nervous system antecedents NEC in premature infants, using heart rate variability (HRV). Materials and Methods HRV was quantified by retrieving archived electrocardiogram (EKG) data from 30 4 days prior, through after, clinical diagnosis. metrics were...
Gamma-aminobutyric acid (GABA) and glutamate are principal neurotransmitters essential for late gestational brain development may play an important role in prematurity-related injury. In vivo investigation of GABA the preterm infant with standard proton magnetic resonance spectroscopy (1H-MRS) has been limited due to its low concentrations developing brain, overlap spectrum by other dominant metabolites. We describe early postnatal profiles measured using J-difference editing technique,...
Despite recent advances in nutrition practice the neonatal intensive care unit, infants remain at high risk for growth restriction following preterm birth. Additionally, optimal values macronutrient administration, especially lipid intake, have yet to be established extrauterine environment.We studied born very low-birth weight (VLBW, <1500 g) and ≤32 weeks' gestation. Cumulative (carbohydrate, lipid, protein, energy) intake first 2 4 weeks of life was compared with total regional brain...
Background The third trimester of gestation is a crucial phase rapid brain development, but little has been reported on the trajectories cerebral blood flow (CBF) in preterm infants this period. Purpose To quantify regional CBF very longitudinally across ex utero and to determine its relationship with clinical factors associated injury premature birth. Materials Methods In prospective study, were enrolled for three longitudinal MRI scans, 22 healthy full-term one term scan between November...
We used a cost-effective, non-invasive method to obtain high-quality DNA from buccal epithelial-cells (BEC) of premature infants for genomic analysis. DNAs BEC were obtained with gestational age ≤ 36 weeks. Short terminal repeats (STRs) performed simultaneously on the swabs and blood same patient. The STR profiles demonstrated that samples originated individual exclude any contamination by external DNAs. Whole exome sequencing was without necrotizing enterocolitis successfully provided total...
Clotting is one of the major causes mortality and morbidity during extracorporeal membrane oxygenation (ECMO). A large meta-analysis study suggests that 29% patients require oxygenator to be replaced ECMO. As clots usually form in oxygenator, blood volume (OXBV) decreases over time. The currently used pressure gradient as a predicator clot formation unreliable.The aim this was develop validate ultrasound dilution technology quantitative assessment clotting, using measurements OXBV.OXBV...
Abstract We need a better risk stratification system for the increasing number of survivors extreme prematurity suffering most severe forms bronchopulmonary dysplasia (BPD). However, there is still paucity studies providing scientific evidence to guide future updates BPD severity definitions. Our goal was validate new predictive model that incorporates respiratory assessments beyond 36 weeks postmenstrual age (PMA). hypothesized this approach improves assessment, particularly in extremely...
Objective: To evaluate the relationship between partial pressure of carbon dioxide (PCO2) during first 3 days life and retinopathy prematurity (ROP) in extremely low birthweight (ELBW) infants.Patients methods: A retrospective evaluation data on ELBW infants were collected over a period 4 years. Data 72 hours was divided into six, 12-hour epochs. The average highest overall means PCO2, PO2, FiO2, glucose calculated for each epoch. Logistic regression analysis used to determine association...
Background: Knowledge of cardiac output is a valuable tool in the treatment critically ill patients. Often, measured indirectly using nonspecific clinical markers. Previous methods direct calculation have involved considerable risk and not been feasible neonatal population. Less invasive exist, but are inaccurate. The COstatus monitor utilizes ultrasound dilution for measurement suitable use It has …
Abstract Objective Tracheobronchomalacia (TBM) is common in neonates with bronchopulmonary dysplasia (BPD) and associated higher morbidity. This study evaluates the value of a CT protocol to assess degree TBM gauge adequacy prescribed PEEP. Study Design Four infants severe BPD on invasive mechanical ventilation underwent chest protocol, including limited reduced- dose expiratory scans varying PEEP levels. Results Baseline was adjusted all subjects after performing Dynamic CT. In two infants,...