A5065334377- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Global Cancer Incidence and Screening
- 14-3-3 protein interactions
- Hair Growth and Disorders
- Chemotherapy-related skin toxicity
- Body Contouring and Surgery
- Peptidase Inhibition and Analysis
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Palliative Care and End-of-Life Issues
- PI3K/AKT/mTOR signaling in cancer
- Cancer Cells and Metastasis
- Advanced biosensing and bioanalysis techniques
- Health Literacy and Information Accessibility
- Meningioma and schwannoma management
- Occupational and environmental lung diseases
Hospital de Clínicas
2011-2024
Universidad de la República
2012-2023
Universidad de Montevideo
2023
Hospital Británico de Buenos Aires
2015
Hospital Británico
2015
Duran i Reynals Hospital
2007
Hospital de Mataró
2007
Institut Català d'Oncologia
2006
Head and neck squamous cell carcinoma (HNSCC) incidence is high in South America, where recent data on survival are sparse. We investigated the main predictors of HNSCC Brazil, Argentina, Uruguay, Colombia.
Mutations in STK11 (STK11Mut) and, frequently co-occurring, KEAP1 mutations (KEAP1Mut) are associated with poor survival metastatic Non-small Cell Lung Cancer (mNSCLC) patients treated immunotherapy. However, there limited data regarding the prognostic or predictive significance of these genomic alterations among Hispanics.This retrospective study analyzed a cohort Hispanic (N = 103) diagnosed mNSCLC from US and seven Latin American countries (LATAM) immune checkpoint inhibitors (ICI) alone...
Epidermal growth factor receptor (EGFR) mutations (EGFRm) represent one of the most common genomic alterations identified among patients with non-small cell lung cancer (NSCLC). Several targeted agents for EGFRm have been proven safe and effective, including third-generation tyrosine kinase inhibitor (TKI) osimertinib. Nonetheless, some will present or develop EGFR-TKI resistance mechanisms. We characterized landscape primary to osimertinib Hispanic EGFR-mutant NSCLC. An observational...
ABSTRACT Background Globally, most people with head and neck cancers (HNCs) are diagnosed advanced‐stage disease. HNC diagnostic stage has multifactorial explanations, the role of health system factors not yet fully investigated. Methods centres ( n = 18) from HEADSpAcE Consortium were surveyed via a bespoke questionnaire covering range factors. Centres compared using least square means for presence/absence each factor to their proportion HNC. Results Health associated lower in diagnosis...
// Andrés F. Cardona 1, 2, 3, * , Leonardo Rojas 4, 5, Beatriz Wills Oscar Arrieta 6, Hernán Carranza 3 Carlos Vargas Jorge Otero Luis Corrales-Rodriguez 7 Claudio Martín 8 Noemí Reguart 9 Pilar Archila 2 July Rodríguez Mauricio Cuello 10 Ortíz 1 Sandra Franco Christian Rolfo 11 Rafael Rosell 12 on behalf of the CLICaP # Clinical and Traslational Oncology Group, Institute Oncology, Clínica del Country, Bogotá, Colombia Foundation for Applied Cancer Research (FICMAC), Department, Faculty...
Lung cancer is a leading cause of cancer-related deaths in Latin America, with non-small cell lung (NSCLC) being the most prevalent. The current study aimed to report real-world data on epidermal growth factor receptor (EGFR) mutational testing and treatment regimens at diagnosis progression patients metastatic NSCLC across four American countries (Argentina, Chile, Colombia Uruguay). A retrospective, multicenter, observational was conducted using medical records from participating...
Lung cancer represents a considerable global health threat, leading the list in terms of cancer-related deaths worldwide. An important proportion lung cases occur within Latin America, and current projections show that over next decade, number due to will double region, underscoring need implement evidence-based interventions improve outcomes. Several challenges have limited progress research America for many years, though recently surge multidisciplinary, transnational, transcultural groups...
In this multi-ancestry genome-wide association study (GWAS) and fine mapping of head neck squamous cell carcinoma (HNSCC) subsites, we analysed 19,073 cases 38,857 controls identified 29 independent novel loci. We provide robust evidence that a 3' UTR variant in
Objective To evaluate the efficacy and safety of pemetrexed, carboplatin bevacizumab (PCB) followed by maintenance therapy with pemetrexed (PB) in chemotherapy-naïve patients stage IV non-squamous non-small cell lung cancer (NSCLC) through influence thymidylate synthase (TS) protein mRNA expression on several outcomes. The primary endpoints were overall response rate (ORR), progression-free survival (PFS) (OS). Methods A cohort 144 administered (500 mg/m2), (AUC, 5.0 mg/ml/min) (7.5 mg/kg)...
Adjuvant hormone therapy (HT) in patients with receptor-positive breast cancer (BC) increases overall survival (OS). A lack of adherence to adjuvant endocrine is common, 31.0-73.0% women discontinue treatment before 5 years. The aim the study was assess HT routine clinical practice assisted at Clinical Oncology Department Hospital de Clinicas - Universidad la Republica, Uruguay.Patients treated for stage 0-III BC between 2017 and 2019 were included. medication possession (MPR) rate...
To compare the rate disparity between outcomes (overall survival (OS), progression-free (PFS), and safety) of concurrent chemoradiation (cCRT) followed by durvalumab in two patient cohorts with locally advanced (LA) stage III non-small cell lung cancer (NSCLC), one non-Hispanic White (NHW), other Latin-American.A multicenter retrospective study was performed, including 80 Hispanic 45 NHW LA NSCLC patients treated cCRT durvalumab. Both were analyzed terms main (OS, PFS, compared them PACIFIC...
Background Malignant pleural mesothelioma (MPM) is an aggressive tumor, associated with poor prognosis. There a lack of information about the clinical and pathological features related survival in Latin American population. Methods The MeSO‐CLICaP registry identified 302 patients advanced MPM diagnosed treated between January 2008 March 2016. Cox model was applied to determine variables survival. A random forest tree built predict response first‐line chemotherapy among patients. Results...
Chemotherapy-induced hair loss in cancer is usually temporary but can take a significant emotional toll on patients and lead to treatment refusal many cases. Although reversible, regrowth months, causing greater psychological distress. Recent years have seen the emergence of cold caps, or scalp cooling systems, designed prevent at least reduce chemotherapy-induced loss. The results date are encouraging. We review evidence effects effectiveness these which making their way into routine...
Abstract Background Thymomas are a group of rare neoplasms the anterior mediastinum. The objective this study was to describe demographics, clinical characteristics and treatment approaches in Latin America. Methods This retrospective multicenter cohort including patients with histologically proven thymomas diagnosed between 1997 2018. Demographics, clinicopathological therapeutic outcomes were collected locally analyzed centralized manner. Results A total 135 included. Median age at...
125 Background: Colorectal cancer (CRC) is the second most diagnosed in men and women Uruguay. Survival from CRC known to be worse those aged 65 years older, despite more than 70% of cases occurring this age group. It has been said that elderly patients are often under-treated compared younger ones, unequal access treatment practice, universal theory, accounts for at least some reported survival difference. A better understanding age-related inequalities would help inform interventions...