A5074835287- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Glioma Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Lung Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Meningioma and schwannoma management
- Chronic Lymphocytic Leukemia Research
- Neutropenia and Cancer Infections
- Genomics and Rare Diseases
- Cancer therapeutics and mechanisms
- Chemical Reactions and Isotopes
- Peptidase Inhibition and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Brain Metastases and Treatment
- Pituitary Gland Disorders and Treatments
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Ocular Oncology and Treatments
- COVID-19 diagnosis using AI
Foundation for Clinical and Applied Cancer Research
2019-2024
Universidad El Bosque
2020-2024
Garrahan Hospital
2024
Fundación para la Investigación, Docencia y Prevención del Cáncer
2021
Mutations in STK11 (STK11Mut) and, frequently co-occurring, KEAP1 mutations (KEAP1Mut) are associated with poor survival metastatic Non-small Cell Lung Cancer (mNSCLC) patients treated immunotherapy. However, there limited data regarding the prognostic or predictive significance of these genomic alterations among Hispanics.This retrospective study analyzed a cohort Hispanic (N = 103) diagnosed mNSCLC from US and seven Latin American countries (LATAM) immune checkpoint inhibitors (ICI) alone...
Background To compare survival outcomes of patients with advanced or metastatic non‐small cell lung cancer (NSCLC) who received immunotherapy as first‐, second‐ beyond line, versus matched receiving standard chemotherapy special characterization hyperprogressors. Methods A retrospective cohort study 296 unresectable/metastatic NSCLC treated either, second‐, third‐ fourth‐line was conducted. comparison a historical first‐line and random forest tree analysis to characterize hyperprogressors...
Epidermal growth factor receptor (EGFR) mutations (EGFRm) represent one of the most common genomic alterations identified among patients with non-small cell lung cancer (NSCLC). Several targeted agents for EGFRm have been proven safe and effective, including third-generation tyrosine kinase inhibitor (TKI) osimertinib. Nonetheless, some will present or develop EGFR-TKI resistance mechanisms. We characterized landscape primary to osimertinib Hispanic EGFR-mutant NSCLC. An observational...
alterations are associated with intracranial tumors in the pediatric population, including pineoblastoma, pituitary blastoma, and recently described "primary
PURPOSE Multidisciplinary molecular tumor boards (MTBs) decode complex genomic data into clinical recommendations. Although MTBs are well-established in the oncology practice developed countries, this strategy needs to be better explored developing countries. Herein, we describe possible benefits and limitations of first MTB established Colombia. METHODS Demographic, clinical, information was collected between August 2020 November 2021. By mid-2020, an created discuss cases with one or more...
PURPOSE In the midst of a global pandemic, evidence suggests that similar to other severe respiratory viral infections, patients with cancer are at higher risk becoming infected by COVID-19 and have poorer prognosis. METHODS We modeled mortality intensive care unit (ICU) requirement for in Latin America. A dynamic multistate Markov model was constructed. Transition probabilities were estimated on basis published reports cumulative probability complications. Basic reproductive number (R0)...
The KRAS exon 2 p. G12C mutation in patients with lung adenocarcinoma has been increasing relevance due to the development and effectiveness of new treatment medications. Studies around different populations indicate that regional variability between ethnic groups ancestries could play an essential role developing this molecular alteration within cancer.In a prospective retrospective cohort study on samples from 1000 administrative regions Colombia were tested for p.G12C mutation. An...
Purpose Identifying actionable oncogenic mutations have changed the therapeutic landscape in different types of tumors. This study investigated utility comprehensive genomic profiling (CGP), a hybrid capture-based next-generation sequencing (NGS) assay, clinical practice developing country. Methods In this retrospective cohort study, CGP was performed on samples from patients with solid tumors recruited between December 2016 and November 2020, using profiling, at individual treating...
Background The intestinal microbiota is an important factor in modulating immune‐mediated tumor cell destruction. Alterations the microbiome composition have been linked to reduced efficacy of immune checkpoint inhibitor (ICI) therapies. Therefore, antibiotic treatment (ATB), which modifies diversity gut bacteria populations, could lead a ICI treatments. Methods This was retrospective cohort study. Patients with advanced non‐small lung cancer (NSCLC) treated anti‐programmed death ligand‐1...
Human papilloma virus (HPV) has been associated with the development and modulation of response in a series neoplasms. In case lung adenocarcinoma, its role etiology pathogenesis is still controversial. Considering that this infection brings foreign epitopes, it could be prognostic significance patients adenocarcinoma treated immunotherapy.In retrospective cohort study we evaluated presence HPV genomic material primary lesions INNO-LiPA platform. Viral replication was also by detecting...
Primary melanocytic tumors of the CNS are extremely rare conditions, encompassing different disease processes including meningeal melanoma and melanocytosis. Its incidence range between 3-5%, with approximately 0.005 cases per 100,000 people. Tumor biological behavior is commonly aggressive, poor prognosis very low survivability, a high recurrence rate, even after remission multimodal treatments. Specific genetic alterations involving gene transcription, alternative splicing, RNA...
Lung cancer is a public health problem, and squamous cell carcinoma (SCC) the second most prevalent subtype of this neoplasm. Compared to other subtypes, including adenocarcinoma, SCC less well understood in terms molecular pathogenesis, limiting therapeutic options among targeted agents approved for disease subgroups. In study, we sought characterize genomic profile using validated Next Generation Sequencing (NGS) platform.The comprehensive NGS assay (TruSight Tumor 170) was used order...
Fragmento
 “El auténtico genio consiste en la capacidad para evaluar información incierta, aleatoria y contradictoria” (Winston Churchill). Con este enunciado se resalta importancia de generar contenido fiable calidad a través los diferentes medios comunicación disponibles tiempos pandemia. SARS-CoV-2 (Severe Acute Respiratory Coronavirus 2, por sus siglas inglés) el virus causal COVID-19, ha diseminado una forma rápida lo largo 188 países del mundo, reportando alrededor 6 millones...
BIM activation is essential for epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-triggered apoptosis in EGFR-mutant non-small-cell lung cancer (NSCLC). A deletion the intron two of gene results generation alternatively spliced isoforms that impairs their apoptotic response to TKIs, conferring NSCLC cells intrinsic resistance these medications. Patients with both alterations have poor clinical evolution. The current study aimed investigate efficacy and tolerability...
Post Transplant lymphoproliferative disorders (PTLD), the most common neoplasms in transplanted children are mostly associated with Epstein-Barr virus (EBV). The aims of our study were: 1. To describe, a cohort kidney transplant patients (KTx), cumulative incidence, incidence rate, time onset (early <1 yr vs. late >1 yr), and clinical histopathological characteristics PTLD; 2. compare patient graft survival between those without PTLD and, EBV negative, association peri-transplant...
Abstract Background Thymomas are a group of rare neoplasms the anterior mediastinum. The objective this study was to describe demographics, clinical characteristics and treatment approaches in Latin America. Methods This retrospective multicenter cohort including patients with histologically proven thymomas diagnosed between 1997 2018. Demographics, clinicopathological therapeutic outcomes were collected locally analyzed centralized manner. Results A total 135 included. Median age at...