A5072569354- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- Autoimmune and Inflammatory Disorders Research
- Lymphoma Diagnosis and Treatment
- Virus-based gene therapy research
- Mosquito-borne diseases and control
- Immunotherapy and Immune Responses
- Biomedical Ethics and Regulation
- Multiple and Secondary Primary Cancers
- Inflammasome and immune disorders
- RNA and protein synthesis mechanisms
- Neurofibromatosis and Schwannoma Cases
- Renal cell carcinoma treatment
- Chemical Reactions and Isotopes
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Kawasaki Disease and Coronary Complications
Mayo Clinic in Florida
2021-2025
Mayo Clinic in Arizona
2021-2024
Instituto Neurológico de Colombia
2024
Mayo Clinic Hospital
2021-2024
University of Arizona
2023
WinnMed
2021-2023
Fundación Valle del Lili
2019-2023
Foundation for Clinical and Applied Cancer Research
2022-2023
Universidad El Bosque
2022
Phoenix (United States)
2022
There are limited studies in Latin America regarding the chronic consequences of Chikungunya virus (CHIK), such as post-CHIK inflammatory rheumatism (pCHIK-CIR). We assessed largest cohort so far pCHIK-CIR America, at municipality La Virginia, Risaralda, a new endemic area CHIK Colombia.We conducted retrospective study Colombia 283 patients diagnosed with that persisted after minimum 6 weeks and up to maximum 26.1 weeks. pCHIK cases were identified according validated criteria via...
<ns4:p><ns4:italic>Objective: </ns4:italic>There are limited studies in Latin America regarding the chronic consequences of Chikungunya virus (CHIK), such as post-CHIK inflammatory rheumatism (pCHIK-CIR). We assessed largest cohort so far pCHIK-CIR America, at municipality La Virginia, Risaralda, a new endemic area CHIK Colombia.</ns4:p><ns4:p><ns4:italic>Methods:</ns4:italic> conducted retrospective study Colombia 283 patients diagnosed with that persisted after minimum 6 weeks and up to...
Mutations in STK11 (STK11Mut) and, frequently co-occurring, KEAP1 mutations (KEAP1Mut) are associated with poor survival metastatic Non-small Cell Lung Cancer (mNSCLC) patients treated immunotherapy. However, there limited data regarding the prognostic or predictive significance of these genomic alterations among Hispanics.This retrospective study analyzed a cohort Hispanic (N = 103) diagnosed mNSCLC from US and seven Latin American countries (LATAM) immune checkpoint inhibitors (ICI) alone...
Chimeric Antigen Receptor (CAR) T-cell therapies have emerged as an effective and potentially curative immunotherapy for patients with relapsed or refractory malignancies. Treatment CD19 CAR T-cells has shown unprecedented results in hematological malignancies, including heavily leukemia, lymphoma, myeloma cases. Despite these encouraging results, therapy faces limitations, the lack of long-term responses nearly 50-70% treated low efficacy solid tumors. Among other reasons, restrictions are...
Epidermal growth factor receptor (EGFR) mutations (EGFRm) represent one of the most common genomic alterations identified among patients with non-small cell lung cancer (NSCLC). Several targeted agents for EGFRm have been proven safe and effective, including third-generation tyrosine kinase inhibitor (TKI) osimertinib. Nonetheless, some will present or develop EGFR-TKI resistance mechanisms. We characterized landscape primary to osimertinib Hispanic EGFR-mutant NSCLC. An observational...
alterations are associated with intracranial tumors in the pediatric population, including pineoblastoma, pituitary blastoma, and recently described "primary
PURPOSE Multidisciplinary molecular tumor boards (MTBs) decode complex genomic data into clinical recommendations. Although MTBs are well-established in the oncology practice developed countries, this strategy needs to be better explored developing countries. Herein, we describe possible benefits and limitations of first MTB established Colombia. METHODS Demographic, clinical, information was collected between August 2020 November 2021. By mid-2020, an created discuss cases with one or more...
Background Intravenous immunoglobulin (IVIG) is prepared using purified human plasma. IVIG therapy has immunomodulatory effects on autoimmune diseases, including severe systemic lupus erythematosus (SLE). However, reports of its large cohorts are scarce. Methods This single-center retrospective study included SLE patients treated with at least one cycle for complications. Demographic data, indications, numbers, and clinical improvement were evaluated. Disease Activity Index 2000 (SLEDAI-2K)...
The KRAS exon 2 p. G12C mutation in patients with lung adenocarcinoma has been increasing relevance due to the development and effectiveness of new treatment medications. Studies around different populations indicate that regional variability between ethnic groups ancestries could play an essential role developing this molecular alteration within cancer.In a prospective retrospective cohort study on samples from 1000 administrative regions Colombia were tested for p.G12C mutation. An...
Human papilloma virus (HPV) has been associated with the development and modulation of response in a series neoplasms. In case lung adenocarcinoma, its role etiology pathogenesis is still controversial. Considering that this infection brings foreign epitopes, it could be prognostic significance patients adenocarcinoma treated immunotherapy.In retrospective cohort study we evaluated presence HPV genomic material primary lesions INNO-LiPA platform. Viral replication was also by detecting...
To compare the rate disparity between outcomes (overall survival (OS), progression-free (PFS), and safety) of concurrent chemoradiation (cCRT) followed by durvalumab in two patient cohorts with locally advanced (LA) stage III non-small cell lung cancer (NSCLC), one non-Hispanic White (NHW), other Latin-American.A multicenter retrospective study was performed, including 80 Hispanic 45 NHW LA NSCLC patients treated cCRT durvalumab. Both were analyzed terms main (OS, PFS, compared them PACIFIC...