A5058783901- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Breast Lesions and Carcinomas
- Medication Adherence and Compliance
- Cancer survivorship and care
- Women's cancer prevention and management
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Cancer and Skin Lesions
- Neuroendocrine Tumor Research Advances
- Chemotherapy-induced cardiotoxicity and mitigation
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Patient-Provider Communication in Healthcare
- Family Support in Illness
- Viral Infections and Immunology Research
- Biomedical Ethics and Regulation
- Genomic variations and chromosomal abnormalities
- Childhood Cancer Survivors' Quality of Life
- Breast Implant and Reconstruction
- Health Systems, Economic Evaluations, Quality of Life
- Chromatin Remodeling and Cancer
- Gestational Trophoblastic Disease Studies
- DNA Repair Mechanisms
- Viral gastroenteritis research and epidemiology
Universidad de la República
2019-2024
Universidad de Montevideo
2021-2024
Hospital de Clínicas
2019-2024
Universidad del Desarrollo
2023
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), is an extremely rare and aggressive ovarian cancer subtype associated with SMARCA4 mutations. We report case a 36-year-old woman presenting abdominal pain distension, diagnosed solid-cystic mass advanced disease peritoneal lymphatic dissemination. Exploratory laparotomy pathological analysis confirmed SCCOHT, FIGO stage IIIC, loss expression. The patient received initial chemotherapy PEB regimen, achieving partial response but...
Adjuvant hormone therapy (HT) in patients with receptor-positive breast cancer (BC) increases overall survival (OS). A lack of adherence to adjuvant endocrine is common, 31.0-73.0% women discontinue treatment before 5 years. The aim the study was assess HT routine clinical practice assisted at Clinical Oncology Department Hospital de Clinicas - Universidad la Republica, Uruguay.Patients treated for stage 0-III BC between 2017 and 2019 were included. medication possession (MPR) rate...
This srudy aimed to estimate the prevalence of trastuzumab-induced cardiotoxicity in Uruguayan women diagnosed with human epidermal growth factor receptor 2 (HER2)-positive breast cancer over a 10-year period, who were treated under financial coverage National Resources Fund (Fondo Nacional de Recursos). was an observational, descriptive study based on analysis anonymized database HER2-positive received adjuvant trastuzumab treatment from 2006 2016, provided by Fondo Recursos. Statistical...
Increases in disease-free survival and overall (OS) with the use of adjuvant chemotherapy early breast cancer (BC) are widely known; however, optimal time to initiate treatment remains controversial.To evaluate elapsed between surgery initiation its possible impact on OS patients diagnosed BC stages I-III.This retrospective study included 112 I-III who received at Mastology Unit Hospital de Clínicas Uruguay from 2009 2019. was estimated using Kaplan-Meier method, a Cox proportional hazards...
Abstract In Ashkenazi Jews (AJ) three recurring pathogenic sequence variants (PSVs) are detected in ~2.5% of the general population BRCA1 (c.68_69del = 185delAG, c.5266dup 5382insC), and BRCA2 (c.5946del 6174delT). Population-based screening for these PSVs AJ women is part health basket Israel. To assess feasibility outcome BRCA genotyping Jewish Uruguay, greater Montevideo area were recruited using ethically approved protocol without pretest counseling genotyped predominant genes....
The first-line treatment for human epidermal growth factor receptor 2-positive (HER2+) metastatic breast cancer (MBC) involves a combination of trastuzumab, pertuzumab, and taxane (TPH). This study assessed the efficacy trastuzumab pertuzumab (PH) in routine practice, following protocols Uruguay's National Resources Fund (FNR), akin to clinical trials.
Phyllodes tumors are rare fibroepithelial tumors, accounting for 2% to 3% of these neoplasms and less than 1% all breast tumors. The standard treatment localized disease is surgical intervention with wide margins, ideally more 1 cm, which significantly improves local control reduces recurrence rates. This case report describes the diagnostic therapeutic challenges encountered in managing a 46- year-old patient malignant phyllodes tumor. We discuss multidisciplinary approach required optimal...
HER-2 positive (+) breast cancer (BC) accounts for 20-25% of BC, it is more aggressive, and has a lower survival rate. Since the approval trastuzumab in 1998, other HER-2-targeted therapies such as pertuzumab emtansine (TDM1) have been introduced, improving patient survival. However, cardiotoxicity an adverse effect these treatments.
Introduction Fulvestrant demonstrated benefits in overall survival and progression-free patients with advanced breast cancer, who are hormone receptor-positive human epidermal growth factor receptor 2 negative. The characteristics, evolution, of receptor-positive, HER2-negative cancer treated fulvestrant were evaluated according to the national treatment coverage protocols National Resources Fund, aim understanding efficacy usual clinical practice comparing our results those from pivotal...
Abstract In Ashkenazi Jews (AJ) three recurring pathogenic sequence variants (PSVs) are detected in ~2.5% of the general population BRCA1 (c.68_69del = 185delAG, c.5266dup 5382insC), and BRCA2 (c.5946del 6174delT). Population‐based screening for these PSVs AJ women is part health basket Israel. To assess feasibility outcome BRCA genotyping Jewish Uruguay, greater Montevideo area were recruited using ethically approved protocol without pretest counseling genotyped predominant genes....
Objetivo. Describir las características clinicopatológicas del cáncer de mama (CM) en mujeres con sobrepeso/obesidad y su manejo la práctica clínica, pacientes uruguayas asistidas Servicio Oncología Hospital Clínicas. Material métodos. Estudio observacional, descriptivo, retrospectivo corte transversal, que incluyó a diagnóstico CM centro ya mencionado, desde enero 2020 mayo 2022. Se evaluaron variables demográficas, índice masa corporal, subtipo histológico, receptores hormonales, HER...
Breast cancer (BC) and its treatment can impair patient quality of life (QoL), those undergoing more aggressive treatments may be severely impacted. Objective: Assess the level perception QoL patients treated for BC at Hospital de Clínicas Departmental Soriano.
Introdução: No Uruguai, o câncer de mama tem a maior incidência e mortalidade todos os cânceres em mulheres. Objetivos: Avaliar conhecimento mulheres uruguaias sobre rastreamento do para detecção precoce CM. Material Métodos: Trata-se um estudo descritivo observacional. Foi aplicado questionário às mulheres, divulgado através das redes sociais. O consentimento informado foi solicitado no início da pesquisa como requisito exclusivo poder realizá-la. Na análise estatística, mantido anonimato...
Male breast cancer (MBC) is a rare condition which, while sharing some similarities with in women, has unique disease profile of its own. Aim: To understand the characteristics MBC and management Uruguay. Patients & methods: Retrospective observational study that included patients diagnosed MBC. Results: 22 cases were found. The median age at diagnosis was 62.5 years. Symptoms self-detected lump 17 (77.3%) nipple retraction seven (22.7%). Ductal carcinomas histological grade 2–3 found 20...