A5101985718- Global Cancer Incidence and Screening
- Connective tissue disorders research
- Asphalt Pavement Performance Evaluation
- Nuclear Physics and Applications
- Family and Disability Support Research
- Nuclear physics research studies
- Ubiquitin and proteasome pathways
- Reservoir Engineering and Simulation Methods
- Drilling and Well Engineering
- Health Literacy and Information Accessibility
- Diverse Education Studies and Reforms
- Advanced Radiotherapy Techniques
- Patient-Provider Communication in Healthcare
- Infrastructure Maintenance and Monitoring
- Advanced MRI Techniques and Applications
- Advances in Oncology and Radiotherapy
- Collaborative Teaching and Inclusion
- Genetic factors in colorectal cancer
- Economic and Financial Impacts of Cancer
- Religious Education and Schools
- CAR-T cell therapy research
- Cytokine Signaling Pathways and Interactions
- Tactile and Sensory Interactions
- Lung Cancer Treatments and Mutations
- Radiopharmaceutical Chemistry and Applications
National Pingtung University of Science and Technology
2024
NeoPhotonics (United States)
2024
Xavier University of Louisiana
2012-2024
University of Calgary
2023
Dunedin Public Hospital
2022
Albert Einstein College of Medicine
2022
The Bronx Defenders
2022
Southern District Health Board
2022
University of Cape Town
1978-2021
Groote Schuur Hospital
2018-2019
Jun N-terminal kinase (JNK) is a stress-activated protein that can be induced by inflammatory cytokines, bacterial endotoxin, osmotic shock, UV radiation, and hypoxia. We report the identification of an anthrapyrazolone series with significant inhibition JNK1, -2, -3 ( K i = 0.19 μM). SP600125 reversible ATP-competitive inhibitor >20-fold selectivity vs. range kinases enzymes tested. In cells, dose dependently inhibited phosphorylation c-Jun, expression genes COX-2 , IL-2 IFN -γ, TNF -α,...
Abstract Activated ALK and ROS1 tyrosine kinases, resulting from chromosomal rearrangements, occur in a subset of non–small cell lung cancers (NSCLC) as well other tumor types their oncogenic relevance actionable targets has been demonstrated by the efficacy selective kinase inhibitors such crizotinib, ceritinib, alectinib. More recently, low-frequency rearrangements TRK kinases have described NSCLC, colorectal carcinoma, glioblastoma, Spitzoid melanoma. Entrectinib, whose discovery...
Infection with human immunodeficiency virus (HIV, or HTLV-III/LAV) results in global immune dysfunction and leads to a breakdown the ability of host mount an response, thereby facilitating unremitting infections by predominantly opportunistic pathogens,1 2 3 4 without Kaposi's sarcoma. These secondary events result organ-system damage some cases organ failure. To date, serious failure has been documented pulmonary, gastrointestinal, renal, central nervous systems.4 5 6 Clinical cardiac...
Abstract Background A DNA methylation signature has been characterized that distinguishes rheumatoid arthritis (RA) fibroblast like synoviocytes (FLS) from osteoarthritis (OA) FLS. The presence of epigenetic changes in long-term cultured cells suggest FLS imprinting might contribute to pathogenic behavior. To understand how differentially methylated genes (DMGs) participate the pathogenesis RA, we evaluated stability RA and whether DMGs are enriched specific pathways ontology categories....
To understand the evolving perspectives and behaviour of directors institutional investors, field research was conducted in 2004–2005 by way a survey with corporate four countries (Australia, Canada, New Zealand United States; n = 658) investors Canada (n 34). Reported changes directors' views practices are substantial consistent across countries, defining characteristic which is fundamental shift positioning board toward becoming strategic partner to management. The role also shifted ways...
Skin testing separately and with equal concentrations of the purified milk proteins, casein, alpha-lactalbumin, beta-lactoglobulin, BSA was done in 85 allergic children. For control purposes, intradermal tests same antigens were 102 normal children 31 to non-milk substances. Six per cent had weakly positive reactions. However, skin occurred 68% allergic, but not milk, 59% milk. In children, incidence reactions each protein similar. The higher than previously apprised. Positive child obtained...
PURPOSE Increased automation has been identified as one approach to improving global cancer care. The Radiation Planning Assistant (RPA) is a web-based tool offering automated radiotherapy (RT) contouring and planning low-resource clinics. In this study, the RPA workflow clinical acceptability were assessed by physicians around world. METHODS output for 75 cases was reviewed at least three physicians; 31 radiation oncologists 16 institutions in six countries on five continents contours plans...
Purpose Breast cancer is the most common in women globally and radiation therapy a cornerstone of its treatment. However, there an enormous shortage radiotherapy staff, especially low‐ middle‐income countries. This could be ameliorated through increased automation treatment planning process, which may reduce workload on staff improve efficiency preparing treatments for patients. To this end, we sought to create automated tool postmastectomy (PMRT). Methods Algorithms automate every step PMRT...
For program-planning purposes, faculty at a small public university were asked if they would make 23 accommodations to students with documented learning disabilities. Accommodations focused on instructional, assignment, and examination modifications. Special assistance academic policy/procedural alterations also examined. Data analyzed using chi-square goodness-of-fit tests determine the significance of responses questionnaire. Results shewed that willing adjustments help disabled compensate...
Although it has been well documented that poor health literacy is associated with limited participation in cancer clinical trials, studies assessing the relationships between (CHL) and research among diverse populations are lacking. In this study, we examined relationship CHL willingness to participate and/or donate bio-specimens (WPRDB) African Americans, Latinos, Whites. Participants completed Cancer Health Literacy Test Multidimensional Questionnaire. Total-scale subscale scores,...
Breast cancer remains one of the leading causes cancer-associated death worldwide. Conventional treatment is associated with substantial toxicity and suboptimal efficacy. We, therefore, developed evaluated in vitro efficacy an autologous dendritic cell (DC) vaccine to treat breast cancer. We recruited 12 female patients stage 1, 2, or 3 matured their DCs tumour-specific lysate, a toll-like receptor (TLR)-3 7/8 agonist, interferon-containing cocktail. The was by its ability elicit cytotoxic...
Purpose The purpose of this paper is to examine relationships between a priori‐chosen personality traits and the tendency for manager rate his/her job performance more favourably than well‐acquainted superiors, peers, subordinates do. Design/methodology/approach 204 managers was evaluated using multi‐source (i.e. 360E) ratings (self, subordinates, superiors). Managers also completed measures. Relationships managers' their own higher superiors did were analyzed advanced regression techniques....
THIS PAPER CONTRIBUTES to a Christian hermeneutic of special education by suggesting the biblical concept hospitality as necessary characteristic classroom and school environments in which students with disabilities other marginalized can be effectively incorporated into body classroom. hospitality, seen teacher's attitude approach milieu classroom, conveys welcome, acceptance, belonging Rather than seeing diversity threat community, hospitable classrooms welcome seek build relationships...
Deadwood-inhabiting bacteria and fungi were crucial in understanding ecosystem functioning carbon turnover. The objectives of this study to investigate microbial succession deadwood analyze bacterial-fungal ratio, composition, diversity various tree species; it explored fungal traits during decomposition uncovered unique networks; thinning effects on composition over three years the roles nitrogen cycle energy metabolism assessed; analysis included carbohydrate-active enzyme gene families,...
Described is the identification of a novel series compounds that blocks activation two key transcription factors, AP-1 and NF-kappa B. These factors regulate expression several critical proinflammatory proteins cytokines represent attractive targets for drug discovery. Through use high throughput screening solution-phase parallel synthesis, inhibitors both B were identified. In subsequent testing, these also shown to block IL-2 IL-8 levels in same cells. One most potent this series, 28, was...
MOVING BEYOND ARGUMENTS from social justice or human rights as a basis for inclusive classrooms, this paper advances ‘theology of interdependence’ rationale creating the classroom ethos desired in Christian education. A theology interdependence provides insight into culture classrooms and forms mainstay an education worldview that stress community. Rather than discussing how-to inclusion, emphasis is on how-to-be inclusive. True collaboration between general special can best be accomplished...
Confluent skin fibroblast cultures were prepared from 40 patients diagnosed with and surgically treated for an abdominal aortic aneurysm. An analysis of secreted type I III collagen in the media these preparations revealed reduced secretion six patients. DNA sequence entire coding domain pro alpha 1 (III) mRNA RNA a C to T substitution at nucleotide 607 one probands that would result replacement leucine residue phenylalanine second position first tripeptide repeat triple-helical collagen....