A5014547131- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- HIV Research and Treatment
- T-cell and B-cell Immunology
- HIV-related health complications and treatments
- Marine Toxins and Detection Methods
- Marine Biology and Environmental Chemistry
- Cell death mechanisms and regulation
- Cancer therapeutics and mechanisms
- Lymphoma Diagnosis and Treatment
- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Organ Transplantation Techniques and Outcomes
- Adenosine and Purinergic Signaling
- Platelet Disorders and Treatments
- Bone Metabolism and Diseases
- Redox biology and oxidative stress
- Nicotinic Acetylcholine Receptors Study
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Pharmacological Effects of Natural Compounds
- Aldose Reductase and Taurine
- Cancer Research and Treatments
- Environmental Toxicology and Ecotoxicology
University of Trieste
2012-2025
Nerviano Medical Sciences
2009-2016
GTx (United States)
2016
University of Bologna
1996-2013
Roma Tre University
2012
University of Milan
2003-2008
University Hospital of Bern
2008
Organ Transplantation and Immunology Institute
2005
Ospedale Maggiore
2005
University of Parma
2004-2005
Abstract Activated ALK and ROS1 tyrosine kinases, resulting from chromosomal rearrangements, occur in a subset of non–small cell lung cancers (NSCLC) as well other tumor types their oncogenic relevance actionable targets has been demonstrated by the efficacy selective kinase inhibitors such crizotinib, ceritinib, alectinib. More recently, low-frequency rearrangements TRK kinases have described NSCLC, colorectal carcinoma, glioblastoma, Spitzoid melanoma. Entrectinib, whose discovery...
The NTRK1 gene encodes Tropomyosin-related kinase A (TRKA), the high-affinity Nerve Growth Factor Receptor. was originally isolated from a colorectal carcinoma (CRC) sample as component of somatic rearrangement (TPM3-NTRK1) resulting in expression oncogenic chimeric protein TPM3-TRKA, but there has been no subsequent report regarding relevance this oncogene CRC. KM12 human CRC cell line expresses TPM3-TRKA and is hypersensitive to TRKA inhibition. We detailed characterization TPM3-NTRK1...
Inflammation generates various changes in body iron homeostasis, including sequestration the reticuloendothelial system with ensuing hypoferremia and anemia of chronic disease. Increased accumulation is caused by hepcidin-mediated down-regulation export protein ferroportin higher uptake. However, enhanced acquisition macrophages cannot be accounted for previously reported transferrin receptor (TfR1) exposed to lipopolysaccharide (LPS)/interferon γ (IFNγ) because it impairs a major uptake...
Abstract Several HIV‐1 infected patients show bone loss and osteopenia/osteoporosis during the course of disease. The mechanisms underlying this degenerative process are largely unsettled it has not been determined yet whether dysfunction is linked to HIV‐1‐mediated direct and/or indirect effects on osteoblasts/osteoclasts cross‐talk regulation. This study investigated IIIb ADA strains osteoblasts using osteoblast‐derived cell line (HOBIT) primary human as cellular models. challenge these...
The roots of Krameria lappacea are used traditionally against oropharyngeal inflammation. So far, the astringent and antimicrobial properties its proanthocyanidin constituents considered to account for anti-inflammatory effect. aim present study was characterize pharmacologically a lipophilic extract K. several isolated lignan derivatives (1–11) in terms their putative activity. dichloromethane (ID50 77 μg/cm2) as well compounds 1–11 0.31–0.60 μmol/cm2) exhibited topical antiedematous...
Besides inhalation, skin contact may be considered one of the most relevant exposure routes to graphene-based materials (GBMs). However, very few data on cutaneous toxicity these are available, so far. This study is focused irritation potential a panel GBMs: few-layer graphene (FLG), exfoliated by ball milling graphite, FLG ultrasonication using sodium dodecyl sulfate (FLG-SDS) or dodecylbenzenesulfonate (FLG-SDBS), CVD-graphene, obtained chemical vapor deposition, oxide (GO) and reduced GO...
Abstract Adenosine released by cells in injurious or hypoxic environments has tissue-protecting and anti-inflammatory effects, which are also a result of modulation macrophage functions, such as vascular endothelial growth factor (VEGF) production. As VEGF is well-known target hypoxia-inducible 1 (HIF-1), we hypothesized that adenosine may activate HIF-1 directly. Our studies using subtype-specific receptor agonists antagonists showed activating the A2A receptor, treatment induced...
An analytical-numerical technique for the scattering problem of a plane wave by cylinder buried under rough surface, based on Cylindrical Wave Approach, is presented. The deviations interface are dealt with means Small Perturbation Method. Reflection and transmission coefficients evaluated in first order approximation, fields sum zeroth-order solution, relevant to flat first-order perturbation fields, associated surface roughnesses. Numerical results obtained through an exact evaluation...
Liver cytosol antibody type 1 (LC1) is regarded as a serologic marker of 2 autoimmune hepatitis, in addition to liver kidney microsomal 1. Among 38 patients with 23 were positive for LC1 antibodies. The antigen recognized by has been identified liver-specific 58-kd metabolic enzyme named formiminotransferase cyclodeaminase (FTCD). All LC1-positive sera immunoprecipitated rat FTCD, and 22 gave an identity reaction FTCD immunodiffusion. No was observed from 10 primary biliary cirrhosis,...
The cellular mechanisms by which ischemic preconditioning increases liver tolerance to ischemia/reperfusion injury are still poorly understood. This study investigated the role of hypoxia-inducible factor-1 (HIF-1) in protection associated with late phase preconditioning. Late was induced primary cultured rat hepatocytes a transient (10 minute) hypoxic stress or 15 minutes incubation adenosine A2A receptors agonist CGS21680 24 hours before exposure 90 hypoxia serum-free medium. nuclear...
Skin contact is one of the most common exposure routes to graphene-based materials (GBMs) during their small-scale and industrial production or use in technological applications. Nevertheless, toxic effects humans by cutaneous GBMs remain largely unexplored, despite skin other related has been associated with adverse effects. Hence, this vivo study was carried out evaluate two GBMs, focusing on sensitization as a possible outcome. few-layer graphene (FLG) oxide (GO) evaluated following...
Harmful algal blooms are an expanding phenomenon negatively impacting human health, socio-economic welfare, and ecosystems. Such events increase the risk of marine organisms' exposure to toxins with consequent ecological effects. In this frame, objective study was investigate ecotoxicological potential three globally distributed dinoflagellate (okadaic acid, OA; dinophysistoxin-1, DTX-1; dinophysistoxin-2, DTX-2) using Artemia franciscana as a model organism zooplankton. Each toxin (0.1-100...
Abstract In this study, we showed the existence of a positive correlation between amount human immunodeficiency virus‐type 1 (HIV‐1) RNA in HIV‐1 seropositive subjects and plasma levels TRAIL. Since it has been previously demonstrated that Tat protein up‐regulates expression TRAIL monocytic cells whereas tat ‐expressing lymphoid are more resistant to cytotoxicity, next investigated effect on expression/activity both apical caspase‐8 ‐10, which play key role mediating initial phases apoptosis...
Abstract The chromosomal translocation t(2;5)(p23;q35) involving the ALK tyrosine kinase gene results in expression of NPM-ALK fusion protein which represents driving force for survival and proliferation a subset Anaplastic Large Cell Lymphoma. More recently, distinct rearrangement leading to new variant EML4-ALK, has been identified as low frequency event, mutually exclusive with respect EGFR K-ras mutation, Non Small Lung cancer patients. As previously found NPM-ALK, this constitutively...
Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is the major lipophilic flavonoid from Artemisia umbelliformis Lam. and genipi Weber, two mountain wormwoods used for production of celebrated alpine liqueur genepy. The topical anti-inflammatory activity eupatilin was investigated using inhibition Croton-oil-induced dermatitis in mouse ear as end point. oedematous response leukocyte infiltration were evaluated up to 48 h after induction phlogosis, comparing with hydrocortisone indomethacin...
Abstract Natural killer (NK) cell function is largely modulated by growth factors and cytokines. In particular, interleukin (IL)‐2, IL‐12, IL‐15 have major effects on the proliferative cytotoxic activities of NK cells against tumor virus‐infected cells. It thought that members protein kinase C (PKC) family serine/threonine kinases play an important role in mediating pleiotropic cytokines their target We investigated downstream generated purified human IL‐2, PKCα PKCϵ—a canonical a novel...
In natural killer (NK) cells, interleukin-2 (IL-2) differentially regulates the expression of several transcription factors, including JunB and c-fos. The cAMP response element binding protein, CREB, is a key transcriptional regulator large number genes containing octanucleotide CRE consensus sequence in their upstream regulatory regions. We studied here thefunctional role CREB IL-2-mediated regulation c-fos human NK cells. Our results show that IL-2 activates cells activation hasa prominent...
We, the Authors, Editor and Publisher of Free Radical Research, have retracted following article:Lorenza Tacchini, Gaetano Cairo, Cristina De Ponti, Marta Massip, Joan Rosellò-Catafau & Carmen Peralta: 'Up regulation IL-6 by ischemic preconditioning in normal fatty rat livers: Association with reduction oxidative stress' 40:11 1206-1217 (2006) DOI 10.1080/10715760600885432.Since above article was published, Chief Research been made aware concerns regarding image manipulation figures 5A 5B,...