A5089322635- earthquake and tectonic studies
- Geological and Geochemical Analysis
- CO2 Sequestration and Geologic Interactions
- Botany and Geology in Latin America and Caribbean
- Geology and Paleoclimatology Research
- High-pressure geophysics and materials
- Seismic Imaging and Inversion Techniques
- Methane Hydrates and Related Phenomena
- Lung Cancer Treatments and Mutations
- Landslides and related hazards
- Hydraulic Fracturing and Reservoir Analysis
- Planetary Science and Exploration
- Hydrocarbon exploration and reservoir analysis
- Geological formations and processes
- Lymphoma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Colorectal Cancer Treatments and Studies
- Geothermal Energy Systems and Applications
- Acute Myeloid Leukemia Research
- Tropical and Extratropical Cyclones Research
- Monoclonal and Polyclonal Antibodies Research
- Cryospheric studies and observations
- Geological and Geophysical Studies Worldwide
- Astro and Planetary Science
Polytechnic University of Turin
2025
Lawrence Berkeley National Laboratory
2012-2021
Rutgers, The State University of New Jersey
2009-2019
Nerviano Medical Sciences
1998-2019
University of Campania "Luigi Vanvitelli"
2019
University of Milan
1993-2015
The Open University
1992-2012
NASA Earth Science
2012
Ethiopian Development Research Institute
2011
Université Clermont Auvergne
2001-2003
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine responsible for the development of different tumor types. Despite remarkable clinical activity crizotinib (Xalkori), first ALK inhibitor approved in 2011, emergence resistance mutations and brain metastases frequently causes relapse patients. Within our drug discovery program, we identified compound 1, novel 3-aminoindazole active on biochemical cellular assays. Its optimization led to 2 (entrectinib), potent orally available...
Experiments were conducted to study the spreading of volcanic constructs. Volcanoes are simulated by a sand cone, and substratum is layer (brittle substratum) overlying silicone (ductile substratum). Similarity conditions between natural volcanoes experimental prototypes led definition dimensionless π numbers. determine values which predict whether or not takes place. Of particular importance ratio thickness brittle height volcano (π 2 ) brittle/ductile 3 ). indicates that must be large...
The established models of the structure and dynamics a “typical” Hawaiian volcano lead inevitably to paradox: finite element viscoelastic calculations, using TECTON [ Melosh Raefsky , 1980, 1981], predict that compressional stress field should characterize their upper flanks; instead, extension is observed. paradox solved by postulating volcanic evolution determined feedback processes related growth spreading edifice. Many examples process are documented in geologic literature on volcanoes...
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine involved in the development of several human cancers and, as result, recognized target for small-molecule inhibitors treatment ALK-positive malignancies. Here, we present crystal structures unphosphorylated ALK domain complex with ATP competitive ligands PHA-E429 and NVP-TAE684. Analysis these provides valuable information concerning specific characteristics active site well giving indications about how to obtain selective inhibitors....
The NTRK1 gene encodes Tropomyosin-related kinase A (TRKA), the high-affinity Nerve Growth Factor Receptor. was originally isolated from a colorectal carcinoma (CRC) sample as component of somatic rearrangement (TPM3-NTRK1) resulting in expression oncogenic chimeric protein TPM3-TRKA, but there has been no subsequent report regarding relevance this oncogene CRC. KM12 human CRC cell line expresses TPM3-TRKA and is hypersensitive to TRKA inhibition. We detailed characterization TPM3-NTRK1...
As volcanoes grow, they become ever heavier. Unlike mountains exhumed by erosion of rocks that generally were lithified at depth, typically are built poorly consolidated may be further weakened hydrothermal alteration. The substrates upon which rest, moreover, often sediments no more than the weight volcanic overburden. It is not surprising, therefore, deformation includes—and in long term dominated by—spreading motions translate subsidence near summits to outward horizontal displacements...
Accurate rheological data for silicate melts and crystal‐melt, melt‐vapor, crystal‐melt‐vapor suspensions of both natural compositions simple binary ternary systems are useful in constraining theories momentum transport magmatic melt structure. Data addressing these problems presented a series papers which this is the first. A high‐torque wide‐gap concentric cylinder viscometer has been constructed used characterization rheometric properties rhyolitic magma under conditions varying...
Long sublinear ridges and related scarps located at the base of large volcanic structures are frequently interpreted as normal faults associated with extensional regional stress. In contrast, bordering Central Costa Rica range (CCRVR) topographic expression hanging wall asymmetric angular anticlines overlying low‐angle thrust range. These formed by gravitational failure slumping flanks due to weight edifices were perhaps triggered intrusion magma over past 20,000 years. The fault underlying...
Abstract Growing volcanoes load their basements, causing isostatic flexure, compaction and brittle ductile deformation. Deformation of basement in turn exerts stress onto the edifice, which also responds by deforming. This deformation will be gradual or catastrophic, depending on nature cone, properties underlying rocks. The physical substratum, most especially viscosity, can vary greatly. Thus a substratum lava support volcano to greater extent than fine clastic Compaction, crustal sagging...
We integrate geologic, structural, leveling and Differential SAR Interferometry data to show that Vesuvius began spread onto its sedimentary substratum about 3,600 years ago. Moreover, we model the detected deformation with a solution of lubrication approximation Navier‐Stokes equations spreading may continue for 7,200 more. Correlation volcanic phases eruptive activity suggests Plinian eruptions, which are thought pose major hazard, less likely occur in near future.
We used SAR interferometry and GPS to measure the rise of an anticline beneath urban area Catania (Italy), which originates from outward thrusting above basal decollement Etna volcano. The grows at a rate over 0.015 m −1 SE about 0.007 relative uplift. By relating this growth simultaneous extension measured summit volcano, we demonstrate occurrence active volcanic spreading. This process may exert control on eruptions, earthquakes, sector collapses, landslides.
We study the state of deformation Tenerife (Canary Islands) using Differential Synthetic Aperture Radar Interferometry (DInSAR). apply Small BAseline Subset (SBAS) DInSAR algorithm to radar images acquired from 1992 2005 by ERS sensors determine rate distribution and time series for coherent pixels identified in island. Our analysis reveals that summit area volcanic edifice is characterized a rather continuous subsidence extending well beyond Las Cañadas caldera rim corresponding dense core...