A5038365059- RNA modifications and cancer
- RNA Research and Splicing
- Cervical Cancer and HPV Research
- Acute Lymphoblastic Leukemia research
- Retinal Development and Disorders
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Connective tissue disorders research
- Hedgehog Signaling Pathway Studies
- Retinoids in leukemia and cellular processes
- Ubiquitin and proteasome pathways
- Acute Myeloid Leukemia Research
- RNA and protein synthesis mechanisms
- Bioinformatics and Genomic Networks
- Folate and B Vitamins Research
- MicroRNA in disease regulation
- Retinal Diseases and Treatments
- Proteoglycans and glycosaminoglycans research
- Cancer Genomics and Diagnostics
- Fibroblast Growth Factor Research
- Protease and Inhibitor Mechanisms
- Congenital limb and hand anomalies
- Marine Toxins and Detection Methods
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Universidad Nacional Autónoma de México
2012-2019
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2019
Institute of Ophthalmology
2013-2017
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016
Centro Medico Nacional Siglo XXI
2011-2013
Mexican Social Security Institute
2011-2012
Acute lymphoblastic leukemia (ALL) is a malignant neoplasm with the highest incidence in pediatric population. Although 5-year overall survival greater than 85%, emerging countries such as Mexico, mortality rate high. In B-ALL most common type of childhood cancer; different characteristics suggest presence disease; however, prognosis dependent on clinical and laboratory features, no adverse prognostic molecular marker for has yet been identified. The present research aimed to identify value...
Human Papillomavirus (HPV) in cervical epithelium has been identified as the main etiological factor developing of Cervical Cancer (CC), which recently become a public health problem Mexico. This finding allowed for development vaccines that help prevent this infection. In present study, we aimed to determine prevalence and HPV type-distribution Mexican women with CC, high-grade squamous intraepithelial lesion (HSIL), low-grade (LSIL), Normal cytology (N) estimate impact vaccines.The PubMed...
In this study of chemoprevention in the rat modified resistant hepatocyte model, preneoplastic cells were diminished by >60% with quercetin pretreatment compared those rats treated N-Diethylnitrosamine (DEN) to induce liver cancer. This decrease occurred associated an abolished DEN-induced lipid peroxidation as well activation caspase 9 and increased 3, determined expression cleaved 3 9, but not 8 fragmentation Poly (ADP-ribose) polymerase (PARP) inducing apoptosis presumed genetically...
Abstract Background Studies of alternative mRNA splicing (AS) in health and disease have yet to yield the complete picture protein diversity its role physiology pathology. Some forms cancer appear be associated certain splice variants, but their development outcome is unclear. Methods We examined AS profiles by means whole genome exon expression microarrays (Affymetrix GeneChip 1.0) ovarian tumors cancer-derived cell lines, compared healthy tissue. Alternatively spliced genes expressed...
B-cell acute lymphoblastic leukemia is the most commonly diagnosed childhood malignancy worldwide; more than 50% of these cases are in Mexico. Although five-year survival rate >80%, 30% patients experience relapse with poor prognosis. Cancer-associated gene expression profiles have been identified several malignancies, and some transcripts used to predict disease The human transcriptome incompletely elucidated; moreover, 80% can be processed via alternative splicing (AS), which increases...
BACKGROUND The irradiation of red blood cells (RBCs) causes damage the RBC membrane with increased potassium (K) leak during storage compared nonirradiated units similar age. A previous in vitro study showed a mean reduction K 94 ± 5% adsorption filter (PAF). STUDY DESIGN AND METHODS prospective, single‐center, nonblinded, randomized controlled trial (RCT) was designed to evaluate safety and efficacy transfusing irradiated PAF. Patients 18 years age or older who received due...
The relationship between Human Papillomavirus (HPV) infection and conjunctiva cancer is controversial. HPV detection will provide more information about the role of this infectious agent in biology cancer. In present study, DNA extracted purified from 36 Conjunctival Squamous Cell Carcinomas (CSCC) was evaluated by PCR for sequences. results were correlated with clinical histopathological variables.The showed that 8 CSCC samples (22%); HPV16 sole type detected. Significant association found...
Droplet digital PCR is the most robust method for absolute nucleic acid quantification. However, RNA a very versatile molecule and its abundance tissue-dependent. quantification dependent on reference control to estimate abundance. Additionally, in cancer, many cellular processes are deregulated which consequently affects gene expression profiles. In this work, we performed microarray data mining of different childhood cancers healthy controls. We selected four genes that showed no...
Aims: Osteoporosis-pseudoglioma syndrome (OPPG) is an uncommon autosomal recessive disorder characterized by the rare association of early-onset osteoporosis and severe ocular abnormalities such as persistent fetal vasculature microphthalmia. Biallelic mutations in low-density lipoprotein receptor-related protein-5 gene (LRP5) have been associated with OPPG. We present clinical genetic data from three Mexican OPPG patients, a pair sibs, sporadic case. Materials Methods: Three patients...
Ovarian cancer is possibly the sixth most common malignancy worldwide, in Mexico representing fourth leading cause of gynecological death more than 70% being diagnosed at an advanced stage and survival very poor. tumors are classified according to histological characteristics, epithelial ovarian as (~80%). We here used high-density microarrays a systems biology approach identify tissue-associated deregulated genes. Non-malignant showed gene expression profile associated with immune mediated...
Nasopalpebral lipoma‐coloboma syndrome (NPLCS, OMIM%167730) is an uncommon malformation entity with autosomal dominant inheritance characterized by the combination of nasopalpebral lipoma, colobomas in upper and lower eyelids, telecanthus, maxillary hypoplasia. To date, no genetic defects have been associated familial or sporadic NPLCS cases etiology disease remains unknown. In this work, results whole exome sequencing a patient are presented. Exome identified de novo heterozygous frameshift...
Craniofrontonasal syndrome (CFNS) is an X-linked disorder caused by mutations in the EFNB1 gene and characterized distinctive craniofacial digital malformations. In contrast with most traits, female patients CFNS display a more severe phenotype than males. this report, clinical, molecular RNA expression analyses of subject are described. A novel c.445_449delGAGGG deletion exon 3 was demonstrated patient. To assess effect mutation at transcript level, mRNA studied quantitative RT-PCR. our...
Abstract Background B‐cell acute lymphoblastic leukemia (B‐ALL) is the most commonly diagnosed childhood malignancy worldwide and especially common in Mexico. Additionally, number of cases has increased recent years. Thus, it very important to develop molecular strategies diagnose leukemia. The aim this study was investigate MYB expression determine its impact on diagnosis B‐ALL. Methods We analyzed B‐ALL gene profile by microarray data mining. Bioinformatics analysis performed identify...
We report on an adult male with normal intelligence who exhibited unusual combination of microcephaly, dysostoses limbs, vertebrae, patellae, and pubic bone, camptodactyly all fingers, syndactyly toes, absent nails thumbs some bilateral cataract, cryptorchidism, polythelia, nipple‐like skin pigmentations shoulders upper back. have been unable to find a description similar manifestations in literature. The cause the anomalies remains unknown. © 2014 Wiley Periodicals, Inc.
Leukemia is the most common childhood malignancy in Mexico, representing more than 50% of all cancers. Although treatment leads to a survival up 90% developing countries, our country, it less 65%. Additionally, ~30% patients relapse with poor prognosis. Alternative splicing plays an important role transcriptome diversity and cellular biology. This mechanism promotes increase assortment proteins potentially distinct functions from single gene. The proliferating cell nuclear antigen (PCNA)...