A5072335333- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Lipid Membrane Structure and Behavior
- Pharmacological Effects and Toxicity Studies
- Cellular transport and secretion
- Turtle Biology and Conservation
- Metabolism and Genetic Disorders
- Cephalopods and Marine Biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Atomic and Subatomic Physics Research
- Acute Lymphoblastic Leukemia research
- Adipose Tissue and Metabolism
- Neonatal and fetal brain pathology
- Long-Term Effects of COVID-19
- Neuroscience and Neural Engineering
- Angiogenesis and VEGF in Cancer
- Lymphatic System and Diseases
- Tryptophan and brain disorders
- Amino Acid Enzymes and Metabolism
- Diet and metabolism studies
- Neurobiology and Insect Physiology Research
- Neonatal Health and Biochemistry
- Pharmaceutical studies and practices
- Congenital heart defects research
Instituto Nacional de Pediatria
2015-2025
Secretaria de Salud
2022-2024
Universidad Michoacana de San Nicolás de Hidalgo
2011
Universidad Nacional Autónoma de México
2007-2011
Objective: Obesity represents a health risk and several studies have linked this clinical entity to cognitive deficits. Among the neuropsychological rehabilitation tools, Peak, digital application, has shown positive results as therapeutic method. The aim of work was measure, for first time, deficits effects Peak neurohabilitation therapy in patients diagnosed with obesity. Methods: treatment offered parents who agreed lasted 6 months, including neurocognitive evaluation. used five times day...
Synaptic vesicle protein 2A (SV2A) is an integral membrane necessary for the proper function of central nervous system and associated to physiopathology epilepsy. SV2A molecular target anti-epileptic drug levetiracetam its racetam analogs. The binding site in non-covalent interactions between racetams are currently unknown; therefore, silico study was performed explore these issues. Since has not been structurally characterized with X-ray crystallography or nuclear magnetic resonance, a...
Epilepsy is a neurological disorder in which it has been shown that the presence of oxidative stress (OS) implicated epileptogenesis. The literature some antiseizure drugs (ASD) have neuroprotective properties. Levetiracetam (LEV) drug commonly used as an ASD, and studies, found to possess antioxidant Because effects LEV not demonstrated chronic phase epilepsy, objective this study was evaluate, for first time, on oxidant-antioxidant status hippocampus rats with temporal lobe epilepsy (TLE)....
In the pediatric population, epilepsy is one of most common neurological disorders that often results in cognitive dysfunction. It affects patients’ life quality by limiting academic performance and self-esteem increasing social rejection. There are several interventions for neurohabilitation impairment, including LEGO®-based therapy (LEGO® B-T), which promotes neuronal connectivity cortical plasticity through use assembly sets robotic programming. Therefore, aim this study was to analyze...
Synaptic vesicle protein 2A (SV2A), the target of antiepileptic drug levetiracetam (LEV), is expressed ubiquitously in all synaptic terminals. Its levels decrease patients and animal models epilepsy. Thus, changes SV2A expression could be a critical factor response to LEV. Epilepsy characterized by an imbalance between excitation inhibition, hence particular terminals also influence LEV response. was analyzed epileptic hippocampus rats which responded or not LEV, clarify if alone together...
Levetiracetam (LEV) is a drug commonly used as an anticonvulsant. However, recent evidence points to possible role antioxidant. We previously demonstrated the antioxidant properties of LEV by significantly increasing catalase and superoxide dismutase activities decreasing hydrogen peroxide (H2O2) levels in hippocampus rats with temporal lobe epilepsy (TLE) showing scavenging against hydroxyl radical. The aim present work was evaluate, effect on DNA oxidation, determining...
Temporal lobe epilepsy (TLE) is one of the most common forms focal epilepsy. Levetiracetam (LEV) an antiepileptic drug whose mechanism action at genetic level has not been fully described. Therefore, aim present work was to evaluate relevant gene expression changes in dentate gyrus (DG) LEV-treated rats with pilocarpine-induced TLE. Whole-transcriptome microarrays were used obtain differential profiles control (CTRL), epileptic (EPI), and EPI treated for week LEV (EPI + LEV). Quantitative...
Epilepsy is a disorder characterized by predisposition to generate seizures. Levetiracetam (LEV) an antiseizure drug that has demonstrated oxidant–antioxidant effects during the early stages of epilepsy in several animal models. However, effect LEV on activity long-term not been studied. Therefore, objective present study was determine concentrations five antioxidant enzymes and levels four oxidant stress markers hippocampus rats with temporal lobe at 5.7 months after status epilepticus...
Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme that regulates energy metabolism mainly through the pentose phosphate pathway (PPP). It well known this participates in antioxidant/oxidant balance via synthesis of energy-rich molecules: nicotinamide adenine dinucleotide reduced (NADPH), form flavin (FADH) and glutathione (GSH), controlling reactive oxygen species generation. Coronavirus disease 19 (COVID-19), induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a...
RESUMEN: La encefalopatía por hipoxia es causa de discapacidad y requiere nuevas estrategias terapéuticas.El pirofosfato tiamina (PPT) un cofactor esencial enzimas fundamentales en el metabolismo la glucosa, cuya disminución puede conducir a falla síntesis ATP muerte celular.El objetivo este estudio fue determinar si administración PPT, reducir daño celular modelo neonatal ratas.Animales 11 días edad fueron tratados con PPT (130 mg/kg) dosis única o solución salina, una hora antes del...
Temporal lobe epilepsy (TLE), the most common type of focal epilepsy, affects learning and memory; these effects are thought to emerge from changes in synaptic plasticity. Levetiracetam (LEV) is a widely used antiepileptic drug that also associated with reversal cognitive dysfunction. The long-lasting effect LEV treatment its participation plasticity have not been explored early chronic epilepsy. Therefore, through measurement evoked field potentials, this study aimed comprehensively...
Congenital heart disease is defined as an abnormality in the cardiocirculatory structure or function. Various studies have shown that patients with this condition may present cognitive deficits. To compensate for this, several therapeutic strategies been developed, among them, LEGO® Education sets, which use pedagogic enginery to modify function by didactic material based on mechanics and robotics principles. Accordingly, goal of study was evaluate effect habilitation using LEGO®-based...
The ability of sea turtle hatchlings to find the seashore soon after hatching is thought be exclusively dependent upon visual information. Target-oriented movements in most vertebrates, however, relay on combining information gathered through different sensory systems. Hence, this work, we investigated whether olfactory and/or magnetic might complement cues during hatchling’s seaward crawling. Acute deprivation and distorted sensation visually competent resulted a scattering crawling routes...
Blindness leads to a major reorganization of neural pathways associated with touch. Because incoming somatosensory information influences motor output, it is plausible that plasticity occurs in the blind. In this work, we evaluated issue at peripheral level enucleated rats. Whisker muscles rats 160 days age or older showed increased cytochrome oxidase activity, capillary density, plate size, and amplitude evoked field potentials as compared their control counterparts. Such differences were...
Epilepsy is a chronic neurological disease characterized by the presence of spontaneous seizures, with higher incidence in pediatric population. Anti-seizure medication (ASM) may produce adverse drug reactions (ADRs) an elevated frequency and high severity. Thus, objective present study was to analyze, through intensive pharmacovigilance over 112 months, ADRs produced valproic acid (VPA), oxcarbazepine (OXC), phenytoin (PHT), levetiracetam (LEV), among others, administered monotherapy or...