A5031348642- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Neurological Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Arsenic contamination and mitigation
- Pharmacological Effects and Toxicity Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Birth, Development, and Health
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Aldose Reductase and Taurine
- Asymmetric Hydrogenation and Catalysis
- Drug Transport and Resistance Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Neurogenesis and neuroplasticity mechanisms
- Sirtuins and Resveratrol in Medicine
- Prenatal Substance Exposure Effects
- Diabetes and associated disorders
- Clinical Laboratory Practices and Quality Control
- Tryptophan and brain disorders
- Aluminum toxicity and tolerance in plants and animals
Benemérita Universidad Autónoma de Puebla
2015-2024
Hospital de Especialidades
2023
Centro Medico Nacional Siglo XXI
2023
Mexican Social Security Institute
2023
Centre International de Recherche sur le Cancer
2022
National Institute of Environmental Health Sciences
2001-2002
National Cancer Institute
2001-2002
National Institutes of Health
2002
Research Triangle Park Foundation
2002
Although several epidemiologic studies show an association between arsenic exposure and prostate cancer, it is still unknown whether human epithelial cells are directly susceptible to arsenic-induced transformation. This study was designed determine the nontumorigenic cell line RWPE-1 could be malignantly transformed in vitro by arsenite. were continuously exposed 5 micro M arsenite monitored for signs of transformation, assessed as changes matrix metalloproteinase-9 levels. After 29 weeks...
A high calorie intake can induce the appearance of metabolic syndrome (MS), which is a serious public health problem because it affects glucose levels and triglycerides in blood. Recently, has been suggested that MS cause complications brain, since chronic hyperglycemia insulin resistance are risk factors for triggering neuronal death by inducing state oxidative stress inflammatory response affect cognitive processes. This process, however, not clear. In this study, we evaluated effect...
Energy drinks (EDs) are often consumed in combination with alcohol because they reduce the depressant effects of alcohol. However, different researches suggest that chronic use these psychoactive substances can trigger an oxidative and inflammatory response. These processes regulated by both a reactive astrogliosis increase proinflammatory cytokines such as IL‐1 β , TNF‐ α iNOS, causing cell death (apoptosis) at central peripheral nervous systems. Currently, mechanisms toxicity caused mixing...
The increase in the elderly population has generated concern to meet health demands. research efforts elucidate mechanisms of damage associated with aging have also been significantly increased, especially order avoid reduction cognitive abilities geriatric patients, resulting from mainly at level hippocampus during old age. At present, many studies describe resveratrol as an antiaging component. There are reports that it can activate Sirt1 gene related antiaging, emulating effects obtained...
Abstract Cadmium (Cd) is a global pollutant, and its accumulation in the liver causes oxidative stress, inflammation, insulin resistance (IR), metabolic complications. This study investigated whether curcumin treatment could alleviate hepatic IR Wistar rats exposed to sub-chronic cadmium explored underlying molecular pathways. Male were divided into control group (standard normocaloric diet + cadmium-free water) drinking water with 32.5 ppm CdCl 2 ) for 30 days. Oral glucose tolerance,...
The substantial increase in the number of elderly people our societies represents a challenge for biology and medicine. industrialized countries are subject to progressive aging process that translates into an cardiovascular risk population. In present work, activity catalase superoxide dismutase was evaluated, as well markers oxidative stress (concentration nitric oxide total lipoperoxidation its main components: malondialdehyde 4-hydroxyalkene) cardiomyocytes during rats treated with...
Increased dopaminergic activity in the striatum underlies neurobiology of psychotic symptoms schizophrenia (SZ). Beyond impaired connectivity among limbic system, excess dopamine could lead to inflammation and oxidative/nitrosative stress. It has been suggested that atypical antipsychotic drugs attenuate psychosis not only due their modulatory on dopaminergic/serotonergic neurotransmission but also anti-inflammatory/antioxidant effects. In such a manner, we assessed effects risperidone...
Introduction: The emergence of extended-spectrum β-lactamases (ESBLs)-producing Escherichia coli clones are a public health concern worldwide. Scarce information does exist about the spread ESBLs-producing E. in pediatric patients from developing countries.
 Methodology: strains were analyzed by multilocus-sequence-typing, pulsed-field-gel-electrophoresis and phylogenetic group. antimicrobial-resistance genes detected PCR, plasmid content PCR-based replicon-typing. Horizontal transfer...
Prophylactic subacute administration of zinc decreases lipoperoxidation and cell death following a transient cerebral hypoxia-ischemia, thus suggesting neuroprotective preconditioning effects. Chemokines growth factors are also involved in the effect hypoxia-ischemia. We explored whether prevents cortex-hippocampus injury through regulation CCL2, CCR2, FGF2, IGF-1 expression 10 min common carotid artery occlusion (CCAO). Male rats were grouped as follows: (1) Zn96h, injected with ZnCl 2 (one...
Previous studies have proposed that cadmium (Cd) is a metabolic disruptor, which associated with insulin resistance, syndrome, and diabetes. This metal not considered by international agencies for the study of diseases. In this study, we investigate effect metformin on Cd-exposed Wistar rats at lowest-observed-adverse-effect level (LOAEL) dose (32.5 ppm) in drinking water. Metabolic complications exposed to Cd were dysglycemia, dyslipidemia, dyslipoproteinemia, imbalance triglyceride...
The transient hypoxic-ischemic attack, also known as a minor stroke, can result in long-term neurological issues such memory loss, depression, and anxiety due to an increase nitrosative stress. individual or combined administration of chronic prophylactic zinc therapeutic selenium is reduce stress the first seven days post-reperfusion and, antioxidant effect, prevent cell death. Besides, selenium, individually administered, causes antidepressant anxiolytic effects. Therefore, this work...
In the cerebral hypoxia‐ischemia rat model, prophylactic administration of zinc can cause either cytotoxicity or preconditioning effect, whereas therapeutic selenium decreases ischemic damage. Herein, we aimed to explore whether supplementation low doses and could protect from a transient hypoxic‐ischemic event. We administrated (0.2 mg/kg body weight; ip) daily for 14 days before 10 min common carotid artery occlusion (CCAO). After CCAO, sodium selenite (6 μ g/kg 7 days. temporoparietal...
Exercise performance and zinc administration individually yield a protective effect on various neurodegenerative models, including ischemic brain injury. Therefore, this work was aimed at evaluating the combined of subacute prophylactic swimming exercise in transient cerebral ischemia model. The (2.5 mg/kg body weight) provided every 24 h for four days before 30 min common carotid artery occlusion (CCAO), after reperfusion, rats were subjected to Morris Water Maze (MWM). Learning evaluated...
Vanadium(IV/V) compounds have been studied as possible metallopharmaceutical drugs against diabetes mellitus. However, mechanisms of action and toxicological threshold tackled poorly so far. In this paper, our purposes were to evaluate the metabolic activity on dyslipidemia dysglycemia, insulin signaling in liver adipose tissue, toxicology title compound. To do so, previously reported bisammonium tetrakis 4-( N , -dimethylamino)pyridinium decavanadate, formula which is [DMAPH] 4 (NH ) 2 [V...