A5017993303- Genetic Associations and Epidemiology
- Obesity, Physical Activity, Diet
- Nutrition, Genetics, and Disease
- Acupuncture Treatment Research Studies
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Botulinum Toxin and Related Neurological Disorders
- Regulation of Appetite and Obesity
- Birth, Development, and Health
- Blood Pressure and Hypertension Studies
- Pain Mechanisms and Treatments
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Nutritional Studies and Diet
- Diabetes and associated disorders
- Health and Lifestyle Studies
- Metabolism, Diabetes, and Cancer
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Fatty Acid Research and Health
- Folate and B Vitamins Research
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
Centro Medico Nacional Siglo XXI
2013-2024
Instituto Politécnico Nacional
2014-2024
Mexican Social Security Institute
2014-2023
Hospital de Especialidades
2014-2023
Centro Científico Tecnológico Patagónico
2022
Center for Research and Advanced Studies of the National Polytechnic Institute
2014
Recent genome wide association studies (GWAS) and previous positional linkage have identified more than 50 single nucleotide polymorphisms (SNPs) associated with obesity, mostly in Europeans. We aimed to assess the contribution of some these SNPs obesity risk variation related metabolic traits, Mexican children.The six European obesity-related or near FTO, NPC1, ENPP1, NEGR1, GNPDA2 MC4R genes was tested 1,463 school-aged children (N(cases) = 514; N(controls) 949). also assessed effects on...
Abstract Background Obesity is associated with the rise of noncommunicable diseases worldwide. The pathophysiology behind this disease involves increase adipose tissue, being inversely related to adiponectin, but directly insulin resistance and metabolic syndrome (MetS). Therefore, study aimed determine relationship between adiponectin levels each component MetS in eutrophic obese Mexican children. Methods A cross sectional was conducted 190 school-age children classified as 196 eutrophic....
The development of medical diagnostic models to support healthcare professionals has witnessed remarkable growth in recent years. Among the prevalent health conditions affecting global population, diabetes stands out as a significant concern. In domain diagnosis, machine learning algorithms have been widely explored for generating disease detection models, leveraging diverse datasets primarily derived from clinical studies. performance these heavily relies on selection classifier algorithm...
Background/Objectives: Type 2 diabetes mellitus (T2DM) is a major global health challenge, primarily driven by insulin resistance and beta-cell dysfunction. This study investigated the roles of p21-activated kinase 1 (PAK1) calci-um/calmodulin-dependent protein II (CAMKII) in secretion, aiming to elucidate their involvement this process implications T2DM pathophysi-ology. Methods: Using Beta-TC-6 insulinoma cell line, we assessed colocalization interaction PAK1 CAMKII under glucose...
Objective The prevalence of obesity in Mexico has increased at an alarming rate both adults and children. This study was undertaken to test Mexican children the effects single nucleotide polymorphisms (SNP) that have been associated with body mass index (BMI) Europeans. Methods School‐age (N = 1,559, 5‐17 years) were recruited City. Thirty‐five SNPs established on BMI genotyped analyzed individually as a combined gene score (GS). Results FAIM2 (rs7138803), GPRC5BB (rs12444979), MTIF3...
Abstract Obesity, parental history (PH) of type 2 diabetes (T2D), and genes play an important role in T2D development. However, the influence each factor on variability is unclear. This study aimed to investigate obesity (body mass index [BMI], waist/hip ratio), PH, 16 single-nucleotide polymorphisms (SNPs) associated with Mexico, comparing 1234 non-diabetic controls 1219 diabetic patients. To replicate data, a case-control (n = 2904) cross-sectional 1901) were also included. In multivariate...
To assess the effect of Leisure-time physical activity (LTPA) on cardiometabolic risk by nutritional status in Mexican children and adolescents. This was a cross-sectional study conducted with 1,309 participants aged between 5 17 years. Nutritional classified according to BMI Z-score age gender. A previously validated questionnaire used evaluate LTPA; score calculated. Multiple linear regression analysis performed LTPA risk. After adjusting for factors, mild were positively associated (βMild...
Summary Background Dyslipidemia is an important risk factor for the development of several diseases. The genetic component hypertriglyceridemia has been studied in adults, but little known children. Objective objective to evaluate association two variants APOA5 (rs662799) and APOA1 (rs5072) with triglyceride (TG) levels Mexican Methods Anthropometric parameters were measured 1559 children 5–14 years age. DNA was isolated from blood samples. Lipid profiles glucose concentrations determined...
Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable variability, ancestry proportions, and high burden of growth stunting overweight/obesity. To address this knowledge gap, we analyzed densely imputed genetic data a sample Hispanic/Latino adults to identify fine-map variants associated with body mass index (BMI), height, BMI-adjusted waist-to-hip ratio (WHRadjBMI). We conducted GWAS 18 studies/consortia as part...
The Pro12Ala (rs1801282) polymorphism in peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) has been convincingly associated with insulin resistance (IR) and type 2 diabetes (T2D) among Europeans, interaction a high-fat diet. Mexico is disproportionally affected by obesity T2D however, whether the early metabolic complications this population unknown. We assessed association of PPAR-γ2 traits 1457 Mexican children using linear regression models. Interactions between circulating lipids...
INTRODUCTIÓN: Obesity is a serious public health problem in Mexico, the National Health and Nutrition Survey (ENSANUT 2012) reported 34.4% prevalence of overweight, obesity children aged 5-11. Recent research has suggested that gut microbiota may be risk factor through its influence on human metabolism.To evaluate association between intestinal profile among whether this modified depending feeding pattern sample schoolchildren from Mexico City. METODOLOGY AND RESULTS: Cross-sectional study...
Among the diverse genes associated to type 2 diabetes (T2D), β-adrenergic receptors are an excellent candidate study in Mexican population. The objective of this work was analyze association polymorphisms ADRB1 (rs1801253) (Arg389Gly) and ADRB3 (Trp64Arg) with T2D metabolic syndrome (MS). We studied 445 MS patients, 502 552 healthy controls. Anthropometric features complete biochemical profile were evaluated, Arg389Gly Trp64Arg SNPs determined by TaqMan assays. Data analysis adjusted...
ENSANUT 2012 showed a combined prevalence of overweight and obesity 34.4% in Mexican children. Single nucleotide polymorphisms (SNPs) the ADIPOQ ADIPOR2 genes have been reported many populations, but their association with has not confirmed other studies. Our aim was to determine SNPs from children.A total 2,634 children 6 12 years old were enrolled study four IMSS Units Mexico City. We selected 1,469 unrelated (745 normal weight 724 overweight/obese). Phenotype characterization included...
Abstract Context Rare partial/complete loss-of-function mutations in the melanocortin-4 receptor (MC4R) gene are most common cause of Mendelian obesity European populations, but their contribution to Mexican population is unclear. Objective and Design We investigated whether deleterious MC4R contribute children adults. Results provide evidence that p.Ile269Asn (rs79783591) mutation may have arisen modern human populations from a founder event native Mexicans. The Isoleucine 269 perfectly...
Abstract The adipocyte-derived adiponectin hormone bridges obesity and its cardio-metabolic complications. Genetic variants at the ADIPOQ locus, in ADIPOR1 , ADIPOR2 have been associated with concentrations complications diverse ethnicities. However, no studies examined these associations Mexican children. We recruited 1 457 children from Mexico City. Six genetic or near (rs182052, rs2241766, rs266729, rs822393), (rs10920533), (rs11061971) were genotyped. Associations between serum...
SUMMARY Background Mexican children are characterized by a high‐starch intake diet and high prevalence of obesity. Objectives To investigate the association AMY1A / AMY2A copy numbers (CNs) AMY1/AMY2 serum enzymatic activity with childhood obesity in up to 427 337 cases controls. Methods Anthropometric dietary starch data were collected. CN determined using droplet digital PCR (ddPCR) colorimetry, respectively. An individual participant level meta‐analysis between CNVs was also performed....