A5009947931- Gut microbiota and health
- Diet and metabolism studies
- Cervical Cancer and HPV Research
- Cell death mechanisms and regulation
- Gout, Hyperuricemia, Uric Acid
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Sepsis Diagnosis and Treatment
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Reproductive Physiology in Livestock
- Nutritional Studies and Diet
- Hepatitis B Virus Studies
- Neutropenia and Cancer Infections
- Epigenetics and DNA Methylation
- Helminth infection and control
- Parasites and Host Interactions
- T-cell and B-cell Immunology
- Toxoplasma gondii Research Studies
- Genetic and phenotypic traits in livestock
- Autophagy in Disease and Therapy
- Nosocomial Infections in ICU
Instituto Nacional de Salud Pública
2016-2025
Departamento de Epidemiología
2022
Secretaria de Salud
2018-2021
National Institute of Public Health
2017-2019
Zero to Three
2019
Pemex (Mexico)
2015
In children with acute leukemia, gut microbiota is modified secondary to chemotherapy administration, leading gastrointestinal side effects. Probiotics are microorganisms that can restore and may help alleviate symptoms. The aim of this pilot study was assess the effects probiotic supplementation on chemotherapy-induced in leukemia (AL).In randomized study, patients under 17 years age diagnosed AL who were remission induction or reinduction randomly assigned receive (a concentration 5×109...
To evaluate the taxonomic composition of gut microbiome in gout patients with and without tophi formation, predict bacterial functions that might have an impact on urate metabolism.Hypervariable V3-V4 regions 16S rRNA gene from fecal samples (n = 33 n 25, respectively) were sequenced compared to 53 healthy controls. We explored predictive functional profiles using bioinformatics order identify differences taxonomy metabolic pathways.We identified a characterized by lowest richness higher...
The development of metabolic diseases is linked to the gut microbiota. A cross-sectional study involving 45 children (6 12 years old) was conducted investigate relationship between microbiota and childhood obesity. Anthropometric measurements, food-frequency questionnaires (FFQs), feces samples were obtained. Using body mass index (BMI) z-score, we categorized each participant as normal weight (NW), or overweight obese (OWOB). We determined 2 dietary profiles: one with complex carbohydrates...
COVID-19 was the leading cause of death in Mexico between 2020 and 2021. SARS-CoV-2 infection varies widely among individuals populations. Since variations genes related to immune response may play a role susceptibility outcome COVID-19, associations gene polymorphisms (SNPs) IL-6 (- 573G > C, rs1800796), TNF-α 308G A, rs1800629), IFN-γ 1615 C T, rs2069705) with expression levels these proteins nasopharynx serum were evaluated Mexican population mild, severe, or critical COVID-19. A total...
Several pathologies with metabolic origin, such as hyperuricemia and gout, have been associated the gut microbiota taxonomic profile. However, there is no evidence of which bacterial genes are being expressed in microbiome, their potential effects on gout. We sequenced RNA 26 fecal samples from 10 healthy normouricemic controls, asymptomatic (AH), six gout patients. The coding sequences were mapped to KEGG orthologues (KO). compared expression levels using generalized linear models validated...
To investigate the correlation among pro- or anti-inflammatory cytokines and two main gut microbiota phyla in obese children.Anthropometric data were obtained from 890 children under 14 years old to determine degree of obesity. Serum cytokine concentration was measured by ELISA. Relative abundance feces evaluated quantitative RealTime PCR assays.Anthropometric biochemical parameters statistically higher overweigth/ (OW/O) than lean (NW), Increased TNF-α levels found that also have a high...
Gut microbiota is associated with the development of metabolic disorders. To study its association childhood obesity, we performed a cross-sectional 46 children (6-12 years old). We collected fecal samples, food-frequency questionnaires (FFQs), and anthropometric measurements. Shotgun metagenomics were used to obtain microbial taxonomic diversity potential. identified two dietary profiles characterized by complex carbohydrates proteins (pattern 1) saturated fat simple 2). classified each...
In this study, we investigated the effects of aqueous extracts Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum, obtained from three localities (China; and Morelos Michoacan, Mexico) on cervical cells transformed by human papillomavirus (HeLa SiHa) C-33A cancer cells. The were plated in DMEM medium supplemented, incubated presence different concentrations G. lucidum for 24 h. Cell proliferation was determined MTT colorimetric assay viability trypan blue assay. Inhibitory dose (IC50)...
The aim is to determine the prevalence of active infection by herpes simplex virus type 2 (HSV-2) among Mexican women with high-risk human papillomavirus (HR-HPV) cervical infection, recruited from public gynecology and colposcopy services. In a cross-sectional study, HSV-2 antibodies, DNA, HR-HPV DNA were quantified. Significant differences in seroprevalence rates found between negative positive cases. was 28.15% 16.1% (P = .0001), while 6.83% 0.62% .001) for groups, respectively. risk...
Bcl-Xl physically interacts with by cross-linking study (View interaction) Apoptosis is a type of cell death characterized the silent elimination unnecessary or damaged cells, which required for development and tissue homeostasis. Two major routes apoptosis have been described: extrinsic route initiated at surface mediated receptors, like Fas-CD95 [1]; intrinsic mitochondria [2], where many different signals are integrated final decision about fate made. Both linked in some cells Bid, member...
In Mexico, 3 of 10 children are overweight. Fructose intake and relative abundance (RA) Lactobacillus reuteri (L. reuteri) in the intestinal microbiota associated with obesity diabetes adults, but studies limited. This study evaluates association between fructose L. RA adiposity cardiometabolic risk markers Mexican dietary information, profiles, indicators (Body Mass Index, BMI Waste Circumference, WC), were analyzed 1087 aged 6-12 years. Linear regression path analysis models used....
Summary The expression profiles of cytokines and antioxidant genes were determined from an experimental infection with H. contortus in Pelibuey lambs. was followed for 34 days (d) to determine the number eggs per gram (epg) packed cell volume ( PCV ). Differential white counts profile estimations IL ‐2, ‐4, ‐5, ‐6, ‐8, ‐10, ‐13, FC ε R1A, GPX SOD 1 at 0 hour, 4 hours, 2 14 post‐infection PI ) infected control groups. Comparison fold change between 4‐hours, 4‐hours 2‐days 2‐ 14‐days periods...