A5076302182- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Heart Rate Variability and Autonomic Control
- Digestive system and related health
- Epigenetics and DNA Methylation
- Thermoregulation and physiological responses
- Liver Disease Diagnosis and Treatment
National Institute of Genomic Medicine
2020-2021
Instituto Nacional de Salud Pública
2019
Texas Biomedical Research Institute
2018
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2018
Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements adiponectin/leptin ratio (ALR), adipo-insulin index (Adipo-IRi), fasting/postprandial (F/P) immunometabolic phenotyping direct F/P differential...
In Mexico, 3 of 10 children are overweight. Fructose intake and relative abundance (RA) Lactobacillus reuteri (L. reuteri) in the intestinal microbiota associated with obesity diabetes adults, but studies limited. This study evaluates association between fructose L. RA adiposity cardiometabolic risk markers Mexican dietary information, profiles, indicators (Body Mass Index, BMI Waste Circumference, WC), were analyzed 1087 aged 6-12 years. Linear regression path analysis models used....
Cardiovascular disease (CVD) and type 2 diabetes (T2D) are increasing worldwide. This is mainly due to an unhealthy nutrition, implying that variation in CVD risk may be the capacity manage a nutritional load. We examined genomic basis of postprandial metabolism. Our main purpose was introduce GEMM Family Study (Genetics Metabolic Diseases Mexico) as multi-center study carrying out ongoing recruitment healthy urban adults. Each participant received mixed meal challenge provided 5-hours’ time...
The aim of this single center cross-sectional study was to investigate the association between fructose intake and albuminuria in subjects with type 2 diabetes mellitus (T2DM). This is a study. One hundred forty-three T2DM were recruited from Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. median daily estimated prospective food registry during 3 days (2 week-days one weekend day) they divided into low (<25 g/day) high (≥ 25 g/day). Complete clinical biochemical...
We previously reported preliminary characterization of adipose tissue (AT) dysfunction through the adiponectin/leptin ratio (ALR) and fasting/postprandial (F/P) gene expression in subcutaneous (SQ) biopsies obtained from participants GEMM study, a precision medicine research project. Here we present integrative data replication previous findings an increased number symptom-free (SF) adults (N = 124) to improve early biomarkers for cardiovascular (CV)/immunometabolic risk SF with AT...
Abstract Obesity remains as a global epidemic characterized by progressive metabolic dysregulation in glucose homeostasis. Along with genetic association the development of T2D, epigenetic regulation has been suggested significant contributor altered gene expression. Recent studies have described DNA methylation changes insulin-sensitive tissues involved T2D pathogenesis, however dynamics on early stages to alterations is still unclear. We investigated potential signatures 34 asymptomatic...