A5081259084- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Pharmacology and Obesity Treatment
- Natural Antidiabetic Agents Studies
- Diabetes Management and Research
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Health and Lifestyle Studies
- Regulation of Appetite and Obesity
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Hormonal Regulation and Hypertension
- Biochemical Analysis and Sensing Techniques
- Body Contouring and Surgery
- Hormonal and reproductive studies
- Vitamin C and Antioxidants Research
- Liver Disease Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Pregnancy and preeclampsia studies
- Eicosanoids and Hypertension Pharmacology
- Gout, Hyperuricemia, Uric Acid
Universidad de Guadalajara
2014-2023
Secretaría de Salud de Jalisco
1998-2021
Behavioral Tech Research, Inc.
2018
Hospital de Especialidades
2002-2016
Instituto de Desarrollo Tecnológico para la Industria Química
2015
Mexican Social Security Institute
2004-2013
Sociedad Española de Medicina Interna
1991-2012
Departamento de Epidemiología
2001
To meet the worldwide challenge of emerging diabetes, accessible and inexpensive tests to identify insulin resistance are needed.To evaluate sensitivity specificity product fasting, we compared triglycerides glucose (TyG) index, a simple measure resistance, with euglycemic-hyperinsulinemic clamp test.We conducted cross-sectional study general population outpatients Internal Medicine Department at Medical Unit High Specialty Hospital West National Center in Guadalajara, Mexico.Eleven nonobese...
This study evaluated the effect of resveratrol administration on metabolic syndrome, insulin sensitivity, and secretion.A randomized, double-blind, placebo-controlled clinical trial was carried out in 24 patients with diagnosis syndrome accordance International Diabetes Federation criteria. Glucose levels were measured after a 75-gram dextrose load. Triglycerides high-density lipoprotein cholesterol concentrations at baseline also evaluated. Twelve received trans-resveratrol (500 mg) three...
The aim of this study was to evaluate the effect berberine administration on metabolic syndrome, insulin sensitivity, and secretion.A randomized, double-blind, placebo-controlled clinical trial carried out in 24 patients with a diagnosis syndrome. Glucose levels after dextrose load were measured. Triglycerides high-density lipoprotein cholesterol concentrations at baseline also Twelve received hydrochloride (500 mg) three times daily before meals for 3 months. remaining 12 placebo. Area...
An improvement in parameters of glycemic control has been observed with Momordica charantia patients type 2 diabetes mellitus (T2DM). It is unknown whether this through a modification insulin secretion, sensitivity, or both. We hypothesized that M. administration can improve secretion and/or sensitivity T2DM, without pharmacological treatment. The objective the study was to evaluate effect on and sensitivity. A randomized, double-blinded, placebo-controlled, clinical trial carried out 24 who...
Chlorogenic acid has been described as a novel polyphenol with metabolic effects on glucose homeostasis. The aim of this study was to evaluate the effect chlorogenic administration glycemic control, insulin secretion, and sensitivity in patients impaired tolerance (IGT). A randomized, double-blind, placebo-controlled clinical trial performed 30 IGT; 15 randomly assigned oral received 400 mg three times per day for 12 weeks, other placebo same way. Before after intervention, anthropometric...
The aim of this article is to evaluate the effect fucoidan administration on insulin secretion and sensitivity in overweight or obese adults. A randomized, double-blind, placebo-controlled clinical trial was carried out 25 volunteers. Thirteen patients received an oral dose 500 mg once daily before breakfast 12 placebo for 3 months. Before after intervention, fasting glucose 2-h postload, total cholesterol, high-density lipoprotein triglycerides, levels were measured. Low-density cholesterol...
<i>Aim:</i> To evaluate the effect of pomegranate juice on insulin secretion and sensitivity in patients with obesity. <i>Methods:</i> A randomized, double-blind, placebo-controlled clinical trial was carried out 20 obese, adult volunteer subjects. After random allocation intervention, 10 received 120 ml or placebo while a fasted state for 1 month. Glucose, uric acid, creatinine, lipid profile, were measured at baseline, glucose also 30, 60, 90, min. The area under...
OBJECTIVE To assess the effect of diacerein on insulin secretion and metabolic control in drug-naïve patients with type 2 diabetes. RESEARCH DESIGN AND METHODS A randomized, double-blind, placebo-controlled clinical trial was carried out 40 adult profile including interleukin (IL)-1β, tumor necrosis factor-α, IL-6, fasting levels before intervention months afterward. hyperglycemic-hyperinsulinemic clamp technique performed to phases sensitivity. After randomization, 20 received (50 mg once...
To evaluate the effect of ursolic acid on metabolic syndrome, insulin sensitivity, and inflammation, a randomized, double-blind, placebo-controlled clinical trial was carried out in 24 patients (30-60 years) with diagnosis syndrome without treatment. They were randomly assigned to two groups 12 patients, each receive orally 150 mg or homologated placebo once day for weeks. Before after intervention, components sensitivity (Matsuda index), inflammation profile (interleukin-6 C-reactive...
To evaluate the effect of dapagliflozin on insulin secretion and sensitivity in patients with prediabetes.A randomized, double-blind, placebo-controlled clinical trial was carried out 24 adults diagnosed prediabetes without pharmacological treatment. Patients were randomly assigned into two groups 12 each to receive 10 mg oral or placebo once a day during weeks. At baseline at end study, anthropometric metabolic measurements evaluated, including first phase secretion, total sensitivity.After...
Inulin is a non absorbable polysaccharide with prebiotic effects, whose influence on blood lipids or insulin sensitivity not well known:To assess the effect of oral administration inulin lipid profile and in dyslipidemic obese subjects.A clinical trial, double blind, randomized placebo was carried out 12 obese, hypertrygliceridemic hypercholesterolemic subjects between 19 32 years old. The were to receive 7 g/day morning, during 4 weeks. Biochemical metabolic profiles...
Background: Epidemiological data on impaired fasting glucose (IFG) and tolerance (IGT) based a representative Mexican sample are not available; thus, the objectives of this study were to determine prevalence distribution IFG IGT, establish its relationship with obesity in adults. Methods: We performed cross-sectional population-based adults aged 30 65 years. Anthropometric measurements that included waist circumference (WC) total body fat percentage collected mass index calculated. All...
<i>Aim:</i> It was the aim of this study to evaluate effect oral <i>L</i>-carnitine administration on insulin sensitivity and lipid profile in subjects with type 2 diabetes mellitus. <i>Subjects Methods:</i> A randomized, double-blind, placebo-controlled clinical trial carried out 12 diabetes. Six received 1 g orally 3 times a day before meals for period 4 weeks. other individuals took placebo same time, as control group. Before after intervention, were...
To determine the relationship between serum concentrations of uric acid and insulin secretion with hyperglycaemic clamp technique among adults type 2 diabetes mellitus (DM2) without hyperuricemia, we carried out a cross-sectional study on 45 patients both gender. We observed correlation male gender r = 0.710 (P 0.001). Also total was positive 0.295 0.049). As well as adjusted for body mass index demonstrated first, second, phases secretion, respectively, 0.438 0.022), 0.433 0.439 0.024)....
Gymnema sylvestre is a medicinal plant whose consumption has demonstrated benefits on lipid and glucose levels, blood pressure, body weight (BWt). The aim of this study was to evaluate the effect G. administration metabolic syndrome (MetS), insulin secretion, sensitivity. A randomized, double-blind, placebo-controlled clinical trial carried out in 24 patients (without pharmacological treatment), 30-60 years old, with diagnosis MetS accordance modified International Diabetes Federation...
To evaluate the effect of Artemisia dracunculus on glycemic control, insulin sensitivity, and secretion in patients with impaired glucose tolerance (IGT). A randomized, double blind, placebo-controlled clinical trial was performed 24 diagnosis IGT. Before after intervention, levels were measured every 30 min for 2 h a 75-g dextrose load, along glycated hemoglobin A1c (A1C) lipid profile. Twelve received A. (1000 mg) before breakfast dinner 90 days; remaining 12 placebo. Area under curve...