A5056279126- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Glioma Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Neurofibromatosis and Schwannoma Cases
- Mast cells and histamine
- Extracellular vesicles in disease
- Cerebrospinal fluid and hydrocephalus
- Autoimmune Bullous Skin Diseases
- Pituitary Gland Disorders and Treatments
- Domain Adaptation and Few-Shot Learning
- Bone Tumor Diagnosis and Treatments
- Neurosurgical Procedures and Complications
- Food Allergy and Anaphylaxis Research
- Botulinum Toxin and Related Neurological Disorders
- Dermatology and Skin Diseases
- S100 Proteins and Annexins
- Moyamoya disease diagnosis and treatment
- Cancer-related gene regulation
- Oral and Maxillofacial Pathology
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Teratomas and Epidermoid Cysts
University of Chicago
2023-2025
Neurological Surgery
2023-2025
Tecnológico de Monterrey
2019-2024
University of California, Los Angeles
2024
Indiana University – Purdue University Indianapolis
2024
Indiana University School of Medicine
2024
Institute of Ophthalmology
2020
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2019
Instituto Nacional de Neurología y Neurocirugía
2019
Increases in mean lesional iron content by quantitative susceptibility mapping (QSM) ≥6% and/or vascular permeability dynamic contrast enhanced perfusion (DCEQP) ≥40% on MRI have been associated with new symptomatic hemorrhage (SH) cerebral cavernous malformations (CCMs). It is not known if plasma biomarkers can reflect these changes within the lesion proper. This cohort study enrolled 46 CCM patients SH prior year. Plasma samples, QSM and DCEQP were simultaneously acquired at beginning end...
BACKGROUND: Cerebral cavernous malformations (CCMs) are vascular that frequently cause stroke. CCMs arise due to loss of function in one the genes encode CCM complex, a negative regulator MEKK3-KLF2/4 signaling endothelial cells. Gain-of-function mutations PIK3CA (encoding enzymatic subunit PI3K (phosphoinositide 3-kinase) pathway associated with cell growth) synergize gene loss-of-function generate rapidly growing lesions. METHODS: We recently developed model formation closely reproduces...
This systematic review aims to characterize ongoing clinical trials and therapeutic treatment options for chordoma, a rare notochordal remnant tumor that primarily affects the cranial base, mobile spine, sacrum. While radical surgical resection remains cornerstone chordoma management, unique technical challenges posed by its proximity critical neurovascular structures confer tendency towards disease recurrence which often requires additional modalities. In an attempt better understand...
Introduction: Familial cerebral cavernous malformations (FCCM), Sturge-Weber Syndrome (SWS), and hereditary hemorrhagic telangiectasia with brain arteriovenous (HHT) are neurovascular disorders driven by genetic mutations while microbleeds (CMBs) primarily associated the aging process. All different vascular dysmorphisms and/or propensity to bleed. Hypothesis: We hypothesized that common distinct circulating microribonucleic acids (miRNAs), reflecting shared pathobiology, can serve as...
Introduction: Mouse models have been a valuable tool for studying the molecular mechanisms driving cerebral cavernous malformation (CCM) pathogenesis. However, genetically modified mouse do not fully recapitulate human CCM disease, and endothelial dysfunction is implicated in multiple disease processes of brain. Herein, we provide radiation-induced platform dysmorphism physiologic similar to that observed disease. By analyzing gene expression pathway alterations cells, this model enhances...
INTRODUCTION: Emerging research has suggested that the gut microbiome plays a crucial role in modulating multiple disease phenotypes, however without clear mechanism. Recent data metabolites exert an effect on neurovascular unit’s junctional integrity. METHODS: Using stereotactic mouse brain radiation damage model, C57BL/6 mice were radiated to single hemisphere with 40Gy. The was altered via oral antibiotics decontaminate specific flora. In vivo, serial, cone beam computed tomography scans...
BACKGROUND: Cerebral cavernous malformation with symptomatic hemorrhage (SH) are targets for novel therapies. A multisite trial-readiness project ( https://www.clinicaltrials.gov ; Unique identifier: NCT03652181) aimed to identify clinical, imaging, and functional changes in these patients. METHODS: We enrolled adult cerebral patients from 5 high-volume centers SH within the prior year no planned surgery. In addition clinical imaging review, we assessed baseline, 1- 2-year National...
BACKGROUND: Quantitative susceptibility mapping (QSM) and dynamic contrast-enhanced quantitative perfusion (DCEQP) magnetic resonance imaging sequences assessing iron deposition vascular permeability were previously correlated with new hemorrhage in cerebral cavernous malformations. We assessed their prospective changes a multisite trial-readiness project. METHODS: Patients malformation symptomatic (SH) the prior year, without or planned lesion resection irradiation enrolled. Mean QSM DCEQP...
Abstract Background Quantitative susceptibility mapping (QSM) and dynamic contrast enhanced quantitative perfusion (DCEQP) MRI sequences assessing iron deposition vascular permeability were previously correlated with new hemorrhage in cavernous angiomas. We assessed their prospective changes angiomas symptomatic (CASH) a multisite trial readiness project ( clinicaltrials.gov NCT03652181 ). Methods Patients CASH the prior year, without or planned lesion resection irradiation enrolled. Mean...
Degranulation, a fundamental effector response from mast cells (MCs) and platelets, is an example of regulated exocytosis. This process mediated by SNARE proteins their regulators. We have previously shown that several these are essential for exocytosis in MCs platelets. Here, we assessed the role protein SNAP23 using conditional knockout mice, which was selectively deleted either megakaryocyte/platelet or connective tissue MC lineages. found removal platelets results severe defects...
Purpose: This project aimed to develop a stereotactic radiosurgery mouse model of radiation-induced brain injury study endothelial damage within the neurovascular unit (NVU). Classification focal and resulting inflammatory cascade has never been cataloged for assessing intrinsic changes versus extrinsic factors inflammation at NVU. The with invasive models, such as open transcranial or vessel occlusion, introduces multiple variables into system that our can help overcome secondary systemic...
Background: Increase in mean lesional iron content (≥6%) measurement by QSM and vascular permeability (≥ 40%) assessed DCEQP MRI have been associated with new bleeding cavernous angiomas (CA), are used as monitoring biomarkers clinical trial of pharmacotherapy CAs symptomatic hemorrhage (SH). Plasma metabolites CA unsupervised discovery, linked mechanistically to the permissive microbiome angiogenic inflammatory mechanisms CAs. To date, their levels change has not compared during prospective...