A5093007362- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Pancreatic function and diabetes
- Mesenchymal stem cell research
- Neuroendocrine Tumor Research Advances
- Adrenal Hormones and Disorders
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- Hedgehog Signaling Pathway Studies
Centro Medico Nacional Siglo XXI
2023-2024
Mexican Social Security Institute
2023-2024
Hospital de Especialidades
2023-2024
Abstract Context The tumor microenvironment (TME) includes diverse cellular components such as mesenchymal stem cells (MSCs) and immune cells, among others. MSC have been isolated from different tumors they favor cell growth; however, their role in pituitary (PTs) remains unknown. Objective Herein we report the presence of MSCs 2 adrenocorticotropin (ACTH)-secreting PTs causing Cushing disease (MCU), nonfunctioning adenomas gonadotrope differentiation (MNF), nontumoral glands (MS). Methods...
Abstract Pituitary neuroendocrine tumors (PitNET) represent the vast majority of sellar masses. Some behave aggressively, growing rapidly and invading surrounding tissues, with high rates recurrence resistance to therapy. Our aim was establish patterns genomic, transcriptomic methylomic evolution throughout time in primary recurrent from same patient. Therefore, we performed transcriptome- exome-sequencing methylome microarrays aggressive, primary, PitNET Primary showed a similar exome...
Abstract MODY is a heterogeneous group of monogenic forms diabetes which present autosomal dominant inheritance in most cases, early onset, and lack beta-cell autoimmunity. Up to 14 types have been described genes with key roles differentiation, insulin secretion, glucose metabolism. misdiagnosis remains widespread, due overlapping clinical phenotypes remarkable variability within genetic variants across populations. Whole Exome Sequencing (WES) studies are needed identify new non-caucasian...
Abstract Disclosure: D. Marrero-Rodríguez: None. K. Taniguchi-Ponciano: F. Martinez-Mendoza: E. Peña-Martinez: S. Vela-Patiño: Hinojosa-Alvarez: J. Hernandez-Perez: R. Chavez-Santoscoy: Sosa-Eroza: P.E. Espinosa Cardenas: M. Mercado: Pituitary tumors (PT) represent the second most frequent intracranial tumor and this neoplasm arises from adenohypophyseal cells. Prolactin-secreting (PRL-tumors) are commonly of pituitary gland lactotrophs, account for 50% all tumors. highly heterogeneous...
Abstract Disclosure: D. Marrero-Rodríguez: None. K. Taniguchi-Ponciano: F. Martinez-Mendoza: E. Peña-Martinez: S. Vela-Patiño: Hinojosa-Alvarez: J. Hernandez-Perez: R. Chavez-Santoscoy: Sosa-Eroza: P.E. Espinosa Cardenas: M. Mercado: Pituitary tumors (PT) represent the second most frequent intracranial tumor and this neoplasm arises from adenohypophyseal cells. Prolactin-secreting (PRL-tumors) are commonly of pituitary gland lactotrophs, account for 50% all tumors. highly heterogeneous...
Abstract Disclosure: D. Marrero-Rodríguez: None. V. Cortes-Morales: K. Taniguchi-Ponciano: A. Valenzuela-Perez: S. Vela-Patiño: Cano-Zaragoza: F. Martinez-Mendoza: J. Kerbel: Andonegui-Elguera: Montesinos: M. Mercado: The tumor microenvironment (TME) includes diverse cellular components such as mesenchymal stem cells (MSC) and immune cells. MSC are a subset of heterogeneous cell populations characterized by the expression CD105, CD73, CD90 that can differentiate into chondrocytes,...
Abstract Disclosure: K. Taniguchi-Ponciano: None. A. Chavez-Santoscoy: S. Hinojosa-Alvarez: J. Hernandez-Perez: Valenzuela-Perez: Vela-Patiño: Andonegui-Elguera: Cano-Zaragoza: F. Martinez-Mendoza: Kerbel: Z. Zhang: G. Smith: Rubenstein: W. Cheng: N. Mendelev: M. Amper: Zamojski: E. Zaslavsky: F.M. Ruf-Zamojski: S.C. Sealfon: Mercado: D. Marrero-Rodríguez: Pituitary tumors (PT) represent 20% of all intracranial neoplasms. Some behave aggressively, growing rapidly and invading surrounding...